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    TRICYCLIC COMPOUNDS
    3.
    发明申请
    TRICYCLIC COMPOUNDS 审中-公开
    三聚体化合物

    公开(公告)号：US20090181942A1

    公开(公告)日：2009-07-16

    申请号：US12090870

    申请日：2006-10-23

    申请人： Kazuyuki Sugita ,  Masami Otsuka ,  Hitoshi Oki ,  Noriyasu Haginoya ,  Masanori Ichikawa ,  Masao Itoh

    发明人： Kazuyuki Sugita ,  Masami Otsuka ,  Hitoshi Oki ,  Noriyasu Haginoya ,  Masanori Ichikawa ,  Masao Itoh

    IPC分类号： A61K31/55 ,  C07D498/04 ,  C07D513/04 ,  C07D487/04 ,  A61P9/10 ,  A61K31/553 ,  A61K31/554

    CPC分类号： C07D513/04 ,  C07D487/04 ,  C07D498/04

    摘要： The present invention relates to tricyclic compounds each represented by the following formula (I): (wherein, R1, R2, R2′, R3, R4, X, Y and Z have the same meanings as defined in the specification); and a drug containing the compound.Since the compounds according to the present invention exhibit an excellent squalene synthetase inhibitory effect and cholesterol synthesis inhibitory effect so that they are useful as a drug such as preventive and/or remedy for diseases in mammals including humans such as hyperlipemia, e.g., hypercholesterolemia, hypertriglyceridemia, and low HDL cholesterolemia and/or arteriosclerosis.

    摘要翻译： 本发明涉及由下式（I）表示的三环化合物：（其中，R1，R2，R2'，R3，R4，X，Y和Z与说明书中定义相同）; 和含有该化合物的药物。 由于根据本发明的化合物表现出优异的角鲨烯合成酶抑制作用和胆固醇合成抑制作用，因此它们可用作诸如高脂血症（例如高胆固醇血症，高甘油三酯血症）的哺乳动物疾病的预防和/或治疗药物 ，和低HDL胆固醇血症和/或动脉硬化。

    Diamine derivatives
    5.
    发明授权
    Diamine derivatives 有权
    二胺衍生物

    公开(公告)号：US07342014B2

    公开(公告)日：2008-03-11

    申请号：US10773344

    申请日：2004-02-09

    申请人： Toshiharu Ohta ,  Satoshi Komoriya ,  Toshiharu Yoshino ,  Kouichi Uoto ,  Yumi Nakamoto ,  Hiroyuki Naito ,  Akiyoshi Mochizuki ,  Tsutomu Nagata ,  Hideyuki Kanno ,  Noriyasu Haginoya ,  Kenji Yoshikawa ,  Masatoshi Nagamochi ,  Syozo Kobayashi ,  Makoto Ono

    发明人： Toshiharu Ohta ,  Satoshi Komoriya ,  Toshiharu Yoshino ,  Kouichi Uoto ,  Yumi Nakamoto ,  Hiroyuki Naito ,  Akiyoshi Mochizuki ,  Tsutomu Nagata ,  Hideyuki Kanno ,  Noriyasu Haginoya ,  Kenji Yoshikawa ,  Masatoshi Nagamochi ,  Syozo Kobayashi ,  Makoto Ono

    IPC分类号： A61K31/50 ,  A61K31/44 ,  A61K31/445 ,  C07D471/02 ,  C07D401/00

    CPC分类号： C07D513/04 ,  C07D209/42

    摘要： A compound represented by the general formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4  (1) wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 is a group in which Q5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T0 and T1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

    摘要翻译： 由通式（1）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？> Q 1 -N（R 1） - N（R 2） - N（R 2） - T （1）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 1 < / SUP>和R 2是氢原子等; Q 1是可被取代的饱和或不饱和的5或6元环烃基，等等; Q 2是单键等; Q 3是其中Q 5是具有1〜8个碳原子的亚烷基等的基团; T 0和T 1是羰基等; 其盐，其溶剂合物或其N-氧化物。 该化合物可用作预防和/或治疗脑梗塞，脑栓塞，心肌梗死，心绞痛，肺梗塞，肺栓塞，Buerger病，深静脉血栓形成，弥散性血管内凝血综合征，瓣膜或关节置换后血栓形成 ，血管成形术后的血栓形成和再闭塞，全身炎症反应综合征（SIRS），多器官功能障碍综合征（MODS），体外循环期间的血栓形成或血液抽血时的凝血。