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    POLYPHENOL-CONTENT-INCREASING AGENT FOR PLANT
    3.
    发明申请
    POLYPHENOL-CONTENT-INCREASING AGENT FOR PLANT 有权
    用于植物的聚苯酚含量增加剂

    公开(公告)号：US20100173780A1

    公开(公告)日：2010-07-08

    申请号：US12376865

    申请日：2007-07-18

    申请人： Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： C07C229/24 ,  A01N37/02

    CPC分类号： A01N37/44

    摘要： To provide a polyphenol-content-increasing agent which increases the content of polyphenol in a plant. A polyphenol-content-increasing agent for plant, containing, as an active ingredient, a 5-aminolevulinic acid or a derivative thereof represented by the following formula (1):(Chem 1) R2R1NCH2COCH2CH2COR3   (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group which may have a substituent, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, or a salt thereof.

    摘要翻译： 提供增加植物中多酚含量的多酚含量增加剂。 含有下述式（1）所示的5-氨基乙酰丙酸或其衍生物作为活性成分的植物多酚含量增加剂：（化学式1）R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示 氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，可以具有取代基的烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，或其盐。

    Polyphenol-content-increasing agent for plant
    4.
    发明授权
    Polyphenol-content-increasing agent for plant 有权
    植物多酚含量增加剂

    公开(公告)号：US08309493B2

    公开(公告)日：2012-11-13

    申请号：US12376865

    申请日：2007-07-18

    申请人： Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： A01N47/10 ,  A01N47/24 ,  A01N47/20 ,  A01N47/06 ,  A01N37/00 ,  A01N37/44 ,  A01N33/00 ,  A01N37/18

    CPC分类号： A01N37/44

    摘要： To provide a polyphenol-content-increasing agent which increases the content of polyphenol in a plant.A polyphenol-content-increasing agent for plant, containing, as an active ingredient, a 5-aminolevulinic acid or a derivative thereof represented by the following formula (1):(Chem 1) R2R1NCH2COCH2CH2COR3  (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group which may have a substituent, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, or a salt thereof.

    摘要翻译： 提供增加植物中多酚含量的多酚含量增加剂。 含有下述式（1）所示的5-氨基乙酰丙酸或其衍生物作为活性成分的植物多酚含量增加剂：（化学式1）R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示 氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，可以具有取代基的烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，或其盐。

    THERAPEUTIC AGENT FOR MALE STERILITY
    5.
    发明申请
    THERAPEUTIC AGENT FOR MALE STERILITY 有权
    用于男性不育的治疗剂

    公开(公告)号：US20110065787A1

    公开(公告)日：2011-03-17

    申请号：US12736782

    申请日：2009-05-13

    申请人： Setsuko Miyanari ,  Masumi Takahashi ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Setsuko Miyanari ,  Masumi Takahashi ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： A61K31/295 ,  A61K31/197 ,  A61P15/08 ,  A61P15/10

    CPC分类号： A61K31/197 ,  A23L33/10 ,  A23L33/16 ,  A61K33/26 ,  A61K2300/00

    摘要： The present invention is intended to provide an agent for treating male infertility which is highly effective to male infertility, and having few side effects. To achieve the object, an agent for treating male infertility comprising δ-amino levulinic acid shown by general formula (1), its derivative or salt thereof: R2R1NCH2COCH2CH2COR3  (1) [wherein R1 and R2 independently represent a hydrogen atom, alkyl group, acyl group, alkoxycarbonyl group, aryl group, or aralkyl group; R3 represents a hydroxy group, alkoxy group, acyloxy group, alkoxycarbonyloxy group, aryloxy group, aralkyloxy group or amino group] can be used.

    摘要翻译： 本发明旨在提供一种治疗男性不育症的药剂，其对男性不育症具有高度有效性，并且副作用很少。 为了达到上述目的，可以列举通式（1）所示的δ-氨基乙酰丙酸及其衍生物或其盐的治疗男性不育症的药剂：R2R1NCH2COCH2CH2COR3（1）[式中，R1和R2分别表示氢原子，烷基，酰基 基团，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基]。

    Therapeutic agent for male sterility
    6.
    发明授权
    Therapeutic agent for male sterility 有权
    雄性不育的治疗剂

    公开(公告)号：US08563605B2

    公开(公告)日：2013-10-22

    申请号：US12736782

    申请日：2009-05-13

    申请人： Setsuko Miyanari ,  Masumi Takahashi ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Setsuko Miyanari ,  Masumi Takahashi ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： A01N55/02 ,  A61K31/295

    CPC分类号： A61K31/197 ,  A23L33/10 ,  A23L33/16 ,  A61K33/26 ,  A61K2300/00

    摘要： The present invention is intended to provide an agent for treating male infertility which is highly effective to male infertility, and having few side effects. To achieve the object, an agent for treating male infertility comprising δ-amino levulinic acid shown by general formula (1), its derivative or salt thereof: R2R1NCH2COCH2CH2COR3  (1) [wherein R1 and R2 independently represent a hydrogen atom, alkyl group, acyl group, alkoxycarbonyl group, aryl group, or aralkyl group; R3 represents a hydroxy group, alkoxy group, acyloxy group, alkoxycarbonyloxy group, aryloxy group, aralkyloxy group or amino group] can be used.

    摘要翻译： 本发明旨在提供一种治疗男性不育症的药剂，其对男性不育症具有高度有效性，并且副作用很少。 为了达到上述目的，本发明提供一种治疗男性不育症的药剂，其含有通式（1）所示的δ-氨基乙酰丙酸，其衍生物或其盐：R2R1NCH2COCH2CH2COR3（1）[其中R1和R2独立地表示氢原子，烷基，酰基 基团，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基]。

    Diagnostic Agent for Tumor
    7.
    发明申请
    Diagnostic Agent for Tumor 有权
    肿瘤诊断剂

    公开(公告)号：US20080108701A1

    公开(公告)日：2008-05-08

    申请号：US11664065

    申请日：2005-09-22

    申请人： Ichiro Okura ,  Toshiaki Kamachi ,  Shunichiro Ogura ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Ichiro Okura ,  Toshiaki Kamachi ,  Shunichiro Ogura ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： A61K31/197 ,  A61P43/00 ,  C07C229/22

    CPC分类号： C07C229/22 ,  A61K49/0021 ,  G01N33/574

    摘要： According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising δ-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof: R2R1NCH2COCH2CH2COR3   (I) wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.

    摘要翻译： 根据本发明，进行早期检测，所有肿瘤的治疗效果和预后诊断的肿瘤诊断剂本发明的肿瘤诊断剂是包含由式（I）表示的δ-氨基乙酰丙酸的肿瘤诊断剂 ），其衍生物及其盐：<？in-line-formula description =“In-line formula”end =“lead”？> R＆lt; 2＆lt; 1＆gt; NCH 2 COCH 2 CH 2 2（3）（I）<？in-line-formula description =“In 其中R 1和R 2各自独立地表示氢，烷基，酰基，烷氧基羰基，芳基或芳烷基; R 3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，其用于通过测量在其施用后从身体内部或外部收集的样品中的卟啉进行诊断。

    Method of detecting bladder cancer
    8.
    发明授权
    Method of detecting bladder cancer 有权
    检测膀胱癌的方法

    公开(公告)号：US08999296B2

    公开(公告)日：2015-04-07

    申请号：US12988621

    申请日：2009-04-21

    申请人： Keiji Inoue ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Keiji Inoue ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： A61K49/00 ,  A61K31/198 ,  A61K41/00

    CPC分类号： A61K49/0021 ,  A61K41/0061 ,  Y10S514/814

    摘要： Provided is a sensitizing detection agent of an oral or intravenous administration type which enables the detection of bladder cancer with a higher sensitivity without causing pain to the patient. A sensitizing detection agent for bladder cancer comprising 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these is orally or intravenously administered, and a video camera system is inserted via the urethra and a blue light at 380-440 nm is irradiated to observe the red fluorescent part. Further, VLD-M1 is inserted and a blue light at 405 nm is irradiated to observe fluorescence intensity (relative intensity) of the red light part. For oral administration, 20 mg/kg (maximum of 1 g) of ALA is dissolved in 50 mL of a 5% glucose solution prior to the administration.

    摘要翻译： 本发明提供口服或静脉内给药型敏化检测剂，其能够以更高的灵敏度检测膀胱癌，而不会对患者造成疼痛。 通过口服或静脉内施用包含5-氨基乙酰丙酸（ALA），其衍生物或其盐的膀胱癌敏化检测剂，通过尿道插入摄像机系统，并将380-440nm的蓝光 照射以观察红色荧光部分。 此外，插入VLD-M1，照射405nm的蓝色光，以观察红色光部分的荧光强度（相对强度）。 对于口服给药，在施用前将20mg / kg（最多1g）的ALA溶于50mL的5％葡萄糖溶液中。

    Diagnostic agent for tumor
    10.
    发明授权
    Diagnostic agent for tumor 有权
    肿瘤诊断剂

    公开(公告)号：US09340490B2

    公开(公告)日：2016-05-17

    申请号：US11664065

    申请日：2005-09-22

    申请人： Ichiro Okura ,  Toshiaki Kamachi ,  Shunichiro Ogura ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Ichiro Okura ,  Toshiaki Kamachi ,  Shunichiro Ogura ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： A61K31/197 ,  A61P43/00 ,  C07C229/22 ,  A61K49/00 ,  G01N33/574

    CPC分类号： C07C229/22 ,  A61K49/0021 ,  G01N33/574

    摘要： According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising δ-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof: R2R1NCH2COCH2CH2COR3  (I) wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.

    摘要翻译： 根据本发明，进行早期检测，所有肿瘤的治疗效果和预后诊断的肿瘤诊断剂本发明的肿瘤诊断剂是包含由式（I）表示的δ-氨基乙酰丙酸的肿瘤诊断剂 ），其衍生物及其盐：R2R1NCH2COCH2CH2COR3（I）其中R1和R2各自独立地表示氢，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，其用于通过在给药后从身体内部或外部收集的样品中的卟啉测量来诊断。