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1.发明授权公开(公告)号：US09101558B2
公开(公告)日：2015-08-11
申请号：US12679923
申请日：2008-09-26
IPC分类号： A61K39/00 , C12N5/0783 , C12N5/0784
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/544 , C12N5/0639 , C12N5/0646 , C12N2501/2302
摘要： To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor regression effect, both in a cellular immunotherapy for cancer utilizing cells having an anti-tumor activity or antigen presenting cells for activating cells capable of exhibiting an anti-tumor activity. Provided are: a method of treating head and neck cancer, comprising administering an anti-cancer cell composition containing NKT cells activated in vitro with an NKT cell ligand into the tumor-feeding artery, and administering an NKT cell-stimulating agent containing antigen presenting cells treated with an NKT cell ligand through the upper respiratory tract mucous membrane; a use, in anti-cancer treatment of head and neck region, of the anti-cancer cell composition and the NKT cell-stimulating agent; a kit comprising the anti-cancer cell composition and the NKT cell-stimulating agent; and the anti-cancer cell composition.
摘要翻译： 提供一种有效地将肿瘤组织具有抗肿瘤活性的细胞传递给更强的抗肿瘤反应的方法，以及提供更有效的肿瘤消退作用的方法， 用于激活能够表现出抗肿瘤活性的细胞的肿瘤活性或抗原呈递细胞。 本发明提供：一种治疗头颈癌的方法，其特征在于，将含有NKT细胞配体的体外NKT细胞的抗癌细胞组合物与NKT细胞配体施用于肿瘤供给动脉，以及施用含有抗原呈递细胞的NKT细胞刺激剂 通过上呼吸道粘膜用NKT细胞配体进行治疗; 用于抗癌细胞组合物和NKT细胞刺激剂的头颈部区域的抗癌治疗; 包含抗癌细胞组合物和NKT细胞刺激剂的试剂盒; 和抗癌细胞组成。
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2.发明申请公开(公告)号：US20110142813A1
公开(公告)日：2011-06-16
申请号：US12679923
申请日：2008-09-26
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/544 , C12N5/0639 , C12N5/0646 , C12N2501/2302
摘要： To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor regression effect, both in a cellular immunotherapy for cancer utilizing cells having an anti-tumor activity or antigen presenting cells for activating cells capable of exhibiting an anti-tumor activity. Provided are: a method of treating head and neck cancer, comprising administering an anti-cancer cell composition containing NKT cells activated in vitro with an NKT cell ligand into the tumor-feeding artery, and administering an NKT cell-stimulating agent containing antigen presenting cells treated with an NKT cell ligand through the upper respiratory tract mucous membrane; a use, in anti-cancer treatment of head and neck region, of the anti-cancer cell composition and the NKT cell-stimulating agent; a kit comprising the anti-cancer cell composition and the NKT cell-stimulating agent; and the anti-cancer cell composition.
摘要翻译： 提供一种有效地将肿瘤组织具有抗肿瘤活性的细胞传递给更强的抗肿瘤反应的方法，以及提供更有效的肿瘤消退作用的方法， 用于激活能够表现出抗肿瘤活性的细胞的肿瘤活性或抗原呈递细胞。 本发明提供：一种治疗头颈癌的方法，其特征在于，将含有NKT细胞配体的体外NKT细胞的抗癌细胞组合物与NKT细胞配体施用于肿瘤供给动脉，以及施用含有抗原呈递细胞的NKT细胞刺激剂 通过上呼吸道粘膜用NKT细胞配体进行治疗; 用于抗癌细胞组合物和NKT细胞刺激剂的头颈部区域的抗癌治疗; 包含抗癌细胞组合物和NKT细胞刺激剂的试剂盒; 和抗癌细胞组成。
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3.发明申请NKT CELL-STIMULATING AGENT FOR ADMINISTRATION THROUGH UPPER RESPIRATORY TRACT MUCOUS MEMBRANE 审中-公开NKT细胞刺激剂通过上呼吸道麻醉膜进行管理公开(公告)号：US20100129339A1
公开(公告)日：2010-05-27
申请号：US12089230
申请日：2006-10-06
CPC分类号： A61K35/15 , A61K2035/124 , C12N5/0639
摘要： The present invention provides an NKT cell stimulating agent containing antigen-presenting cells pulsed with an NKT cell ligand, to be administered submucosally in the upper airway. By submucosal administration in the upper airway, it is possible to stimulate NKT cells and stimulate immune reactions extremely efficiently with a small number of NKT cell ligand-pulsed antigen-presenting cells. By submucosal administration in the upper airway, NKT cells can be induced selectively in cervical lymph nodes.
摘要翻译： 本发明提供含NKT细胞配体脉冲的抗原呈递细胞的NKT细胞刺激剂，其在上呼吸道中粘膜下施用。 通过在上呼吸道中的粘膜下给药，可以刺激NKT细胞并且用少量NKT细胞配体脉冲的抗原呈递细胞极其有效地刺激免疫反应。 通过在上呼吸道粘膜下给药，可以选择性诱导NKT细胞在子宫颈淋巴结中。
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