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1.发明授权公开(公告)号：US09101558B2
公开(公告)日：2015-08-11
申请号：US12679923
申请日：2008-09-26
IPC分类号： A61K39/00 , C12N5/0783 , C12N5/0784
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/544 , C12N5/0639 , C12N5/0646 , C12N2501/2302
摘要： To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor regression effect, both in a cellular immunotherapy for cancer utilizing cells having an anti-tumor activity or antigen presenting cells for activating cells capable of exhibiting an anti-tumor activity. Provided are: a method of treating head and neck cancer, comprising administering an anti-cancer cell composition containing NKT cells activated in vitro with an NKT cell ligand into the tumor-feeding artery, and administering an NKT cell-stimulating agent containing antigen presenting cells treated with an NKT cell ligand through the upper respiratory tract mucous membrane; a use, in anti-cancer treatment of head and neck region, of the anti-cancer cell composition and the NKT cell-stimulating agent; a kit comprising the anti-cancer cell composition and the NKT cell-stimulating agent; and the anti-cancer cell composition.
摘要翻译： 提供一种有效地将肿瘤组织具有抗肿瘤活性的细胞传递给更强的抗肿瘤反应的方法，以及提供更有效的肿瘤消退作用的方法， 用于激活能够表现出抗肿瘤活性的细胞的肿瘤活性或抗原呈递细胞。 本发明提供：一种治疗头颈癌的方法，其特征在于，将含有NKT细胞配体的体外NKT细胞的抗癌细胞组合物与NKT细胞配体施用于肿瘤供给动脉，以及施用含有抗原呈递细胞的NKT细胞刺激剂 通过上呼吸道粘膜用NKT细胞配体进行治疗; 用于抗癌细胞组合物和NKT细胞刺激剂的头颈部区域的抗癌治疗; 包含抗癌细胞组合物和NKT细胞刺激剂的试剂盒; 和抗癌细胞组成。
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2.发明申请公开(公告)号：US20110142813A1
公开(公告)日：2011-06-16
申请号：US12679923
申请日：2008-09-26
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/544 , C12N5/0639 , C12N5/0646 , C12N2501/2302
摘要： To provide a method of efficiently delivering cells having an anti-tumor activity to tumor tissues to evoke a stronger anti-tumor reaction, and a method of providing a more effective tumor regression effect, both in a cellular immunotherapy for cancer utilizing cells having an anti-tumor activity or antigen presenting cells for activating cells capable of exhibiting an anti-tumor activity. Provided are: a method of treating head and neck cancer, comprising administering an anti-cancer cell composition containing NKT cells activated in vitro with an NKT cell ligand into the tumor-feeding artery, and administering an NKT cell-stimulating agent containing antigen presenting cells treated with an NKT cell ligand through the upper respiratory tract mucous membrane; a use, in anti-cancer treatment of head and neck region, of the anti-cancer cell composition and the NKT cell-stimulating agent; a kit comprising the anti-cancer cell composition and the NKT cell-stimulating agent; and the anti-cancer cell composition.
摘要翻译： 提供一种有效地将肿瘤组织具有抗肿瘤活性的细胞传递给更强的抗肿瘤反应的方法，以及提供更有效的肿瘤消退作用的方法， 用于激活能够表现出抗肿瘤活性的细胞的肿瘤活性或抗原呈递细胞。 本发明提供：一种治疗头颈癌的方法，其特征在于，将含有NKT细胞配体的体外NKT细胞的抗癌细胞组合物与NKT细胞配体施用于肿瘤供给动脉，以及施用含有抗原呈递细胞的NKT细胞刺激剂 通过上呼吸道粘膜用NKT细胞配体进行治疗; 用于抗癌细胞组合物和NKT细胞刺激剂的头颈部区域的抗癌治疗; 包含抗癌细胞组合物和NKT细胞刺激剂的试剂盒; 和抗癌细胞组成。
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3.发明申请NKT CELL-STIMULATING AGENT FOR ADMINISTRATION THROUGH UPPER RESPIRATORY TRACT MUCOUS MEMBRANE 审中-公开NKT细胞刺激剂通过上呼吸道麻醉膜进行管理公开(公告)号：US20100129339A1
公开(公告)日：2010-05-27
申请号：US12089230
申请日：2006-10-06
CPC分类号： A61K35/15 , A61K2035/124 , C12N5/0639
摘要： The present invention provides an NKT cell stimulating agent containing antigen-presenting cells pulsed with an NKT cell ligand, to be administered submucosally in the upper airway. By submucosal administration in the upper airway, it is possible to stimulate NKT cells and stimulate immune reactions extremely efficiently with a small number of NKT cell ligand-pulsed antigen-presenting cells. By submucosal administration in the upper airway, NKT cells can be induced selectively in cervical lymph nodes.
摘要翻译： 本发明提供含NKT细胞配体脉冲的抗原呈递细胞的NKT细胞刺激剂，其在上呼吸道中粘膜下施用。 通过在上呼吸道中的粘膜下给药，可以刺激NKT细胞并且用少量NKT细胞配体脉冲的抗原呈递细胞极其有效地刺激免疫反应。 通过在上呼吸道粘膜下给药，可以选择性诱导NKT细胞在子宫颈淋巴结中。
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公开(公告)号：US07327889B1
公开(公告)日：2008-02-05
申请号：US10089721
申请日：2000-10-03
IPC分类号： G06K9/68
CPC分类号： G07D7/2033 , G06K9/00 , G07D2205/0011
摘要： An image processing portion (1) performs binarization, segmentation, and feature extraction of a received image using a RAM (2), compares the extracted feature with specific pattern data stored in a dictionary data memory (3), performs recognition processing, and provides recognition results to a CPU (4). The dictionary data memory is a volatile memory, in which specific pattern data held by the CPU is written by the CPU when power is turned on. Since the data stored in the volatile memory is erased when power is turned off, the dictionary data memory can be removed and the contents are analyzed when the power is turned off without causing any trouble.
摘要翻译： 图像处理部分（1）使用RAM（2）对接收到的图像进行二值化，分割和特征提取，将所提取的特征与存储在字典数据存储器（3）中的特定图案数据进行比较，执行识别处理，并提供 识别结果到CPU（4）。 字典数据存储器是易失性存储器，其中由CPU保持的特定模式数据由CPU在电源接通时被写入。 由于在电源关闭时存储在易失性存储器中的数据被擦除，所以可以去除字典数据存储器，并且在电源关闭时分析内容，而不引起任何麻烦。
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公开(公告)号：US5567366A
公开(公告)日：1996-10-22
申请号：US267482
申请日：1994-06-29
申请人： Kentaro Motegi , Yukio Ito , Yoshitaka Okamoto , Kuniyoshi Komura
发明人： Kentaro Motegi , Yukio Ito , Yoshitaka Okamoto , Kuniyoshi Komura
IPC分类号： B28B11/00 , B28B11/08 , B28B11/12 , B28B11/18 , B28B11/22 , B28B13/00 , B28B13/04 , B28B17/00 , B28B7/04
摘要： A green body molded in a pressurized slip casting machine is loaded onto a pallet and sent to a conveyor. An image of the green body is picked up from above by a CCD camera, and whether the green body is a rectangular tank or a triangular tank is distinguished. When the green body is a rectangular tank holes are made in it by a first holemaking device, and when the green body is a triangular tank holes are made in it by a second holemaking device. After that, water removal, shape correction, deburring and the like are carried out automatically.
摘要翻译： 在加压成型机中成型的生坯被装载到托盘上并送到输送机上。 通过CCD照相机从上方拾取生坯的图像，并且区分生坯是矩形罐还是三角形罐。 当生坯是矩形罐时，由第一制孔装置制成孔，当生坯为三角形槽时，由第二制孔装置制成孔。 之后，自动进行除水，形状校正，去毛刺等。
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