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10 条记录 (耗时 0.025 秒)

    Method for stabilizing duocarmycin derivatives
    1.
    发明授权
    Method for stabilizing duocarmycin derivatives 失效
    稳定杜卡霉素衍生物的方法

    公开(公告)号：US5703080A

    公开(公告)日：1997-12-30

    申请号：US737145

    申请日：1996-10-30

    申请人： Masashi Nakakura ,  Yuji Ueno ,  Eiji Hayakawa ,  Tokuyuki Kuroda

    发明人： Masashi Nakakura ,  Yuji Ueno ,  Eiji Hayakawa ,  Tokuyuki Kuroda

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K9/19 ,  A61K31/495 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61P35/00 ,  C07D241/04

    CPC分类号： A61K9/19 ,  A61K31/495 ,  A61K47/02 ,  A61K47/26 ,  A61K9/0019

    摘要： Stabilized duocarmycin derivatives represented by formula (I): ##STR1## wherein R is lower alkyl, allyl or benzyl, and X is Cl or Br, are prepared by adding at least a compound selected from the group consisting of a saccharide, an electrolyte, a water-soluble polymer, a polyhydric alcohol and a surfactant to a solution containing the duocarmycin derivatives. Also provided are freeze-dried pharmaceutical preparations containing the stabilized duocarmycin derivatives.

    摘要翻译： PCT No.PCT / JP95 / 00962 Sec。 371日期1996年10月30日 102（e）日期1996年10月30日PCT提交1995年5月19日PCT公布。 公开号WO95 / 31971 日期：1995年11月30日由式（I）表示的稳定化的二焦虑霉素衍生物：其中R是低级烷基，烯丙基或苄基，X是Cl或Br，通过加入至少一种选自 来自由糖类，电解质，水溶性聚合物，多元醇和表面活性剂组成的组，与含有二焦耳霉素衍生物的溶液。 还提供了含有稳定的二焦耳霉素衍生物的冷冻干燥的药物制剂。

    Method of stabilizing antibody and stabilized solution-type antibody preparation
    5.
    发明申请
    Method of stabilizing antibody and stabilized solution-type antibody preparation 有权
    稳定抗体和稳定溶液型抗体制剂的方法

    公开(公告)号：US20070020255A1

    公开(公告)日：2007-01-25

    申请号：US10574016

    申请日：2004-10-01

    申请人： Yuji Ueno ,  Takashi Kayashita ,  Atsushi Ishihara ,  Masashi Nakakura ,  Kyoko Yamauchi

    发明人： Yuji Ueno ,  Takashi Kayashita ,  Atsushi Ishihara ,  Masashi Nakakura ,  Kyoko Yamauchi

    IPC分类号： A61K39/395 ,  C07K16/18

    CPC分类号： A61K9/0019 ,  A61K39/39591 ,  A61K47/12 ,  A61K47/183 ,  C07K16/18 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/76

    摘要： The present invention provides a method of suppressing the formation of a soluble association of an antibody in a solution; a method of suppressing the formation of a chemically degraded product of an antibody in a solution; and a method of stabilizing an antibody in a solution. The present invention also provides a solution-type antibody preparation in which the formation of a soluble association is suppressed; a solution-type antibody preparation in which the formation of a chemically degraded product is suppressed; a solution-type antibody preparation in which the formation of a soluble association, the formation of a chemically degraded product and the formation of an insoluble aggregate are suppressed; an agent for suppressing the formation of a soluble association of an antibody; an agent for suppressing the formation of a chemically degraded product of an antibody; and a stabilizing agent for an antibody.

    摘要翻译： 本发明提供抑制抗体在溶液中的可溶性结合形成的方法; 抑制溶液中抗体的化学降解产物的形成的方法; 以及在溶液中稳定抗体的方法。 本发明还提供抑制可溶性缔合的形成的溶液型抗体制剂; 抑制化学降解产物的形成的溶液型抗体制剂; 抑制了可溶性缔合物的形成，化学降解产物的形成和不溶性聚集体的形成的溶液型抗体制剂; 用于抑制抗体的可溶性缔合的形成的试剂; 用于抑制抗体的化学降解产物形成的试剂; 和抗体的稳定剂。

    EYE DROP CONTAINING DIBENZ[b,e]OXEPIN DERIVATIVE
    6.
    发明申请
    EYE DROP CONTAINING DIBENZ[b,e]OXEPIN DERIVATIVE 审中-公开
    含有DIBENZ [b，e] OXEPIN衍生物的眼药水

    公开(公告)号：US20100227917A1

    公开(公告)日：2010-09-09

    申请号：US12676888

    申请日：2008-09-08

    申请人： Masashi Nakakura ,  Eikichi Ono ,  Kouji Murai ,  Tadafumi Tamura

    发明人： Masashi Nakakura ,  Eikichi Ono ,  Kouji Murai ,  Tadafumi Tamura

    IPC分类号： A61K31/335 ,  C07D313/10

    CPC分类号： A61K9/0048 ,  A61K9/0014 ,  A61K9/0043 ,  A61K31/335

    摘要： The present invention provides an eye drop comprising: a dibenz[b,e]oxepine derivative or a salt thereof and a polyvalent weak acid, an acidic amino acid or an amide thereof, a basic amino acid or an amide thereof, or the salt thereof, and the like, for the purpose of providing an eye drop or a preparation for topical administration which enables the concentration of a dibenz[b,e]oxepin derivative or a salt thereof to be high; or an eye drop or a preparation for topical administration comprising the dibenz[b,e]oxepine derivative or the salt thereof and having an effective composition for treating allergic disturbance or inflammatory disorder of an eye or for treating allergic disturbance or inflammatory disorder of a nose.

    摘要翻译： 本发明提供一种滴眼剂，其包含：二苯并[b，e]氧杂七环衍生物或其盐和多价弱酸，其酸性氨基酸或其酰胺，碱性氨基酸或其酰胺或其盐 为了提供滴定剂或用于局部给药的制剂，其能够使二苯并[b，e]氧杂七环素衍生物或其盐的浓度高; 或滴眼剂或用于局部给药的制剂，其包含二苯并[b，e]氧杂七环衍生物或其盐，并且具有用于治疗眼睛的过敏性紊乱或炎症性疾病或用于治疗鼻子的过敏性紊乱或炎症性疾病的有效组合物 。

    METHOD OF PRODUCING COATED FINE PARTICLES
    8.
    发明申请
    METHOD OF PRODUCING COATED FINE PARTICLES 审中-公开
    生产涂层精细颗粒的方法

    公开(公告)号：US20120301539A1

    公开(公告)日：2012-11-29

    申请号：US13565078

    申请日：2012-08-02

    申请人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    发明人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    IPC分类号： A61K9/14 ,  A61K31/7105 ,  A61K31/713 ,  A61K9/127 ,  A61K31/711

    CPC分类号： A61K9/5123 ,  A61K9/1075 ,  A61K9/5192 ,  A61K31/7088 ,  B01J13/04 ,  Y10T428/2991

    摘要： An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component (s) can be in the dispersed state in the liquid, and the like.

    摘要翻译： 本发明的目的是提供一种容易地生产其中芯细颗粒涂覆有涂层组分等的涂覆微粒的方法。提供了一种制备涂覆微粒的方法，其包括涂覆有涂层的芯细颗粒 包括以下步骤：将芯细颗粒和涂层组分分散在液体中，以及用芯层细颗粒涂覆涂层组分的方法，其中液体含有极性有机溶剂，其中涂层 层组分是可溶的，并且极性有机溶剂的浓度使得芯细颗粒不溶解，并且涂层组分可以在液体中处于分散状态等。

    Method of Producing Fine Particles Surface-Modified with Water-Soluble Substance
    9.
    发明申请
    Method of Producing Fine Particles Surface-Modified with Water-Soluble Substance 有权
    生产用水溶性物质表面改性的微粒的方法

    公开(公告)号：US20080145414A1

    公开(公告)日：2008-06-19

    申请号：US11883169

    申请日：2006-01-27

    申请人： Nobuhiro Yagi ,  Hiroko Sugishita ,  Masashi Nakakura ,  Hiroko Kusano

    发明人： Nobuhiro Yagi ,  Hiroko Sugishita ,  Masashi Nakakura ,  Hiroko Kusano

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61K47/12

    CPC分类号： A61K9/1271 ,  A61K9/0019 ,  A61K9/107 ,  B01J13/02

    摘要： An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.

    摘要翻译： 本发明的目的是提供一种容易地生产包含脂质，脂肪酸或其衍生物的细颗粒的方法，其用水溶性物质表面改性等。提供了一种制备精细的方法 用水溶性物质进行表面改性的粒子，其含有分散包含脂质，脂肪酸或其衍生物的微粒子的工序，溶解或分散作为脂质衍生物的表面改性剂，脂肪酸衍生物 ，或水溶性物质的脂族烃衍生物，在含有极性有机溶剂的液体中等。

    Method Of Producing Coated Fine Particles
    10.
    发明申请
    Method Of Producing Coated Fine Particles 审中-公开
    生产涂层微粒的方法

    公开(公告)号：US20080171090A1

    公开(公告)日：2008-07-17

    申请号：US11883165

    申请日：2006-01-27

    申请人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    发明人： Nobuhiro Yagi ,  Takuya Tokuda ,  Masashi Nakakura ,  Yasuki Kato

    IPC分类号： A61K9/14 ,  A61J3/00 ,  A61P35/00 ,  A61P29/00 ,  B32B1/00

    CPC分类号： A61K9/5123 ,  A61K9/1075 ,  A61K9/5192 ,  A61K31/7088 ,  B01J13/04 ,  Y10T428/2991

    摘要： An object of the present invention is to provide a method for easily producing coated fine particles in which core fine particles are coated with a coating layer component, etc. There are provided a method of producing coated fine particles comprising core fine particles coated with a coating layer component, comprising the steps of dispersing the core fine particles and the coating layer component(s) in a liquid and the process of coating the core fine particles with the coating layer component, wherein the liquid contains a polar organic solvent in which the coating layer component(s) is soluble, and the concentration of the polar organic solvent is such that the core fine particles is not dissolved and the coating layer component(s) can be in the dispersed state in the liquid, and the like.

    摘要翻译： 本发明的目的是提供一种容易地生产其中芯细颗粒涂覆有涂层组分等的涂覆微粒的方法。提供了一种制备涂覆微粒的方法，其包括涂覆有涂层的芯细颗粒 包括以下步骤：将芯细颗粒和涂层组分分散在液体中，以及用芯层细颗粒涂覆涂层组分的方法，其中液体含有极性有机溶剂，其中涂层 层组分是可溶的，并且极性有机溶剂的浓度使得芯细颗粒不溶解，并且涂层组分可以在液体中处于分散状态等。