公开(公告)号：US20080131476A1

公开(公告)日：2008-06-05

申请号：US11885222

申请日：2006-02-28

申请人： Masato Kanzaki ,  Masayuki Yamato ,  Tinatsu Kohno ,  Hidekazu Sekine ,  Akihiko Kikuchi ,  Teruo Okano ,  Takamasa Onuki

发明人： Masato Kanzaki ,  Masayuki Yamato ,  Tinatsu Kohno ,  Hidekazu Sekine ,  Akihiko Kikuchi ,  Teruo Okano ,  Takamasa Onuki

IPC分类号： C12N5/06 ,  A61F2/00

CPC分类号： A61L27/3895 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3839 ,  C12N5/0068 ,  C12N5/0688 ,  C12N2533/30

摘要： It is intended to provide a cultured cell sheet with excellent tissue adherence and flexibility. The above object can be achieved by culturing cells on a support for cell culture in which a surface of a substrate is coated with a temperature-responsive polymer whose lower or upper critical solution temperature against water is in the range of 0 and 80° C. along with a surfactant protein or a crosslinking inhibitor and producing a cultured cell sheet by detaching it by setting the temperature of the culture to the upper critical solution temperature or higher or to the lower critical solution temperature or lower.

摘要翻译： 旨在提供具有优异组织粘附性和柔韧性的培养细胞片。 上述目的可以通过在细胞培养支持体上培养细胞来实现，其中基质的表面被温度响应性聚合物涂覆，其温度较低或上限临界溶解温度对水在0和80℃的范围内。 以及表面活性剂蛋白质或交联抑制剂，通过将培养物的温度设定在上限临界溶液温度以上或降低临界溶解温度以下，通过分离培养的细胞片材。

公开(公告)号：US07985197B2

公开(公告)日：2011-07-26

申请号：US12123005

申请日：2008-05-19

申请人： Masanori Maeda ,  Hidenori Takushima ,  Teruo Okano ,  Masayuki Yamato ,  Hiroshi Iseki ,  Ryoichi Nakamura ,  Takamasa Onuki ,  Masato Kanzaki ,  Takashi Suzuki ,  Shigeru Nagai

发明人： Masanori Maeda ,  Hidenori Takushima ,  Teruo Okano ,  Masayuki Yamato ,  Hiroshi Iseki ,  Ryoichi Nakamura ,  Takamasa Onuki ,  Masato Kanzaki ,  Takashi Suzuki ,  Shigeru Nagai

IPC分类号： A61M31/00

CPC分类号： A61B17/3468

摘要： A therapeutic-substance carrying/administering appliance includes a cylindrical outer sheath; a slide member installed in the cylindrical outer sheath to be slidable therein; and a sheet supporting member, connected to a distal end of the slide member and made of a resilient material, for supporting a sheet-shaped therapeutic substance. The sheet supporting member is held in a flat unrolled shape in a free state in which the sheet supporting member projects outwardly from a distal end of the cylindrical outer sheath. When the sheet supporting member is in the free state, sliding the slide member in a retracting direction causes the sheet supporting member to contact the distal end of the cylindrical outer sheath, and subsequently further moving the slide member in the retracting direction causes the sheet supporting member to be retracted into the cylindrical outer sheath while being deformed into a tubular shape.

摘要翻译： 治疗物质携带/给药器具包括圆柱形外护套; 安装在所述圆筒形外护套中的可在其中滑动的滑动构件; 以及片材支撑构件，其连接到滑动构件的远端并由弹性材料制成，用于支撑片状治疗物质。 片材支撑构件在自由状态下保持为平坦的未卷曲形状，其中片材支撑构件从圆柱形外护套的远端向外突出。 当片材支撑构件处于自由状态时，滑动构件沿缩回方向使片材支撑构件接触圆柱形外护套的远端，并且随后在缩回方向上进一步移动滑动构件使得片材支撑 构件在变形为管状时被缩回到圆柱形外护套中。