公开(公告)号：US20080131476A1

公开(公告)日：2008-06-05

申请号：US11885222

申请日：2006-02-28

申请人： Masato Kanzaki ,  Masayuki Yamato ,  Tinatsu Kohno ,  Hidekazu Sekine ,  Akihiko Kikuchi ,  Teruo Okano ,  Takamasa Onuki

发明人： Masato Kanzaki ,  Masayuki Yamato ,  Tinatsu Kohno ,  Hidekazu Sekine ,  Akihiko Kikuchi ,  Teruo Okano ,  Takamasa Onuki

IPC分类号： C12N5/06 ,  A61F2/00

CPC分类号： A61L27/3895 ,  A61L27/34 ,  A61L27/3804 ,  A61L27/3839 ,  C12N5/0068 ,  C12N5/0688 ,  C12N2533/30

摘要： It is intended to provide a cultured cell sheet with excellent tissue adherence and flexibility. The above object can be achieved by culturing cells on a support for cell culture in which a surface of a substrate is coated with a temperature-responsive polymer whose lower or upper critical solution temperature against water is in the range of 0 and 80° C. along with a surfactant protein or a crosslinking inhibitor and producing a cultured cell sheet by detaching it by setting the temperature of the culture to the upper critical solution temperature or higher or to the lower critical solution temperature or lower.

摘要翻译： 旨在提供具有优异组织粘附性和柔韧性的培养细胞片。 上述目的可以通过在细胞培养支持体上培养细胞来实现，其中基质的表面被温度响应性聚合物涂覆，其温度较低或上限临界溶解温度对水在0和80℃的范围内。 以及表面活性剂蛋白质或交联抑制剂，通过将培养物的温度设定在上限临界溶液温度以上或降低临界溶解温度以下，通过分离培养的细胞片材。

公开(公告)号：US07985197B2

公开(公告)日：2011-07-26

申请号：US12123005

申请日：2008-05-19

申请人： Masanori Maeda ,  Hidenori Takushima ,  Teruo Okano ,  Masayuki Yamato ,  Hiroshi Iseki ,  Ryoichi Nakamura ,  Takamasa Onuki ,  Masato Kanzaki ,  Takashi Suzuki ,  Shigeru Nagai

发明人： Masanori Maeda ,  Hidenori Takushima ,  Teruo Okano ,  Masayuki Yamato ,  Hiroshi Iseki ,  Ryoichi Nakamura ,  Takamasa Onuki ,  Masato Kanzaki ,  Takashi Suzuki ,  Shigeru Nagai

IPC分类号： A61M31/00

CPC分类号： A61B17/3468

摘要： A therapeutic-substance carrying/administering appliance includes a cylindrical outer sheath; a slide member installed in the cylindrical outer sheath to be slidable therein; and a sheet supporting member, connected to a distal end of the slide member and made of a resilient material, for supporting a sheet-shaped therapeutic substance. The sheet supporting member is held in a flat unrolled shape in a free state in which the sheet supporting member projects outwardly from a distal end of the cylindrical outer sheath. When the sheet supporting member is in the free state, sliding the slide member in a retracting direction causes the sheet supporting member to contact the distal end of the cylindrical outer sheath, and subsequently further moving the slide member in the retracting direction causes the sheet supporting member to be retracted into the cylindrical outer sheath while being deformed into a tubular shape.

摘要翻译： 治疗物质携带/给药器具包括圆柱形外护套; 安装在所述圆筒形外护套中的可在其中滑动的滑动构件; 以及片材支撑构件，其连接到滑动构件的远端并由弹性材料制成，用于支撑片状治疗物质。 片材支撑构件在自由状态下保持为平坦的未卷曲形状，其中片材支撑构件从圆柱形外护套的远端向外突出。 当片材支撑构件处于自由状态时，滑动构件沿缩回方向使片材支撑构件接触圆柱形外护套的远端，并且随后在缩回方向上进一步移动滑动构件使得片材支撑 构件在变形为管状时被缩回到圆柱形外护套中。

公开(公告)号：US5681332A

公开(公告)日：1997-10-28

申请号：US553177

申请日：1995-11-07

申请人： Takamasa Onuki

发明人： Takamasa Onuki

IPC分类号： A61B17/12 ,  A61B17/00

CPC分类号： A61B17/12013

摘要： A ligation apparatus includes an opening portion at a front end of a rod, in communication with the front end side, the left side, and the right side, having a cross section of substantially a U-shaped configuration in the direction of axis of the rod, and a mobile unit in the opening portion. The mobile unit includes a body held in a movable manner, and a thread supporting unit having the tip end protruding from the opening portion for supporting a ligature at the front end. The ligature has one end tied to the thread supporting unit of the mobile unit, and the other end translated downwards from the upper side of the mobile unit according to a predetermined direction of rotation, whereby a knot of the ligature is formed. Therefore, a ligation site can be ligated extracorporeally even if the hole puncture in a somatic layer is small.

摘要翻译： 连接装置包括在杆的前端处的开口部分，其与前端侧，左侧和右侧连通，具有基本上U形构造的横截面， 杆和开口部分中的移动单元。 移动单元包括以可移动方式保持的主体，以及线头支撑单元，其具有从开口部分突出的顶端，用于在前端支撑结扎。 连线具有一端连接到移动单元的线支撑单元，另一端根据预定的旋转方向从移动单元的上侧向下平移，由此形成结结。 因此，即使体细胞层中的穿刺孔小，也可以将结扎部位体外结扎。

公开(公告)号：US5662666A

公开(公告)日：1997-09-02

申请号：US623265

申请日：1996-03-28

申请人： Takamasa Onuki ,  Masayoshi Yokoyama ,  Tetsuya Yamamoto

发明人： Takamasa Onuki ,  Masayoshi Yokoyama ,  Tetsuya Yamamoto

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/12 ,  A61B17/28

CPC分类号： A61B17/12013 ,  A61B17/0483 ,  A61B17/0469 ,  A61B17/062 ,  A61B2017/2927

摘要： A ligative suturer according to the present invention comprises a first rod which is connected with a ligative sutural member, and a second rod which is connected with the first rod to be bendable in the horizontal direction (L, R). A thread guard member which is capable of protrusion and storage is provided in the first rod, while a lever which can select the bending direction of the first rod in response to the situation of employment by an operator is provided in the second rod. Due to this ligative suturer, the operator can regularly bend the first rod toward him whether he handles the suturer with his left or right hand.

摘要翻译： 根据本发明的连接缝合线包括与连接缝合构件连接的第一杆和与第一杆连接以在水平方向（L，R）上可弯曲的第二杆。 能够突出并保持的螺纹防护构件设置在第一杆中，而在第二杆中设置有能够根据操作者的使用情况选择第一杆的弯曲方向的杆。 由于这种结扎缝合器，操作者可以定期地将第一杆向他弯曲，无论他用左手还是右手处理缝合线。