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公开(公告)号：US20130178625A1
公开(公告)日：2013-07-11
申请号：US13811714
申请日：2011-07-27
IPC分类号： C07D413/10 , C07D403/10 , C07D401/10 , C07D241/38
CPC分类号： C07D413/10 , C07D241/38 , C07D241/44 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/12
摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is hydrogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl having 1-3 halogens, C1-8 hydroxyalkyl, halogen, hydroxyl, nitro, cyano, amino, C1-8 alkylamino, benzenesulfonylamino optionally having a substituent, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene, tetrahydronaphthalene, or indan ring.
摘要翻译： 使用具有下式（II）的化合物或其药理学上可接受的盐作为P2X4受体拮抗剂：其中R11和R12各自为氢，C1-8烷基等; R 13是氢，C 1-8烷基等; R14是氢，C1-8烷基，C1-8烷氧基，具有1-3个卤素的C1-8烷基，C1-8羟基烷基，卤素，羟基，硝基，氰基，氨基，C1-8烷基氨基，任选具有取代基的苯磺酰基氨基， 任选具有取代基的杂环基等; 由W1和相邻的苯环组成的稠环是萘，四氢萘或茚满环。
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公开(公告)号：US08680110B2
公开(公告)日：2014-03-25
申请号：US13811909
申请日：2011-07-27
IPC分类号： A61K31/517 , A61K31/519 , C07D239/70
CPC分类号： C07D239/70 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/04 , C07D471/04
摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is C1-8 alkoxy, hydroxyl, cyano, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene ring or the like.
摘要翻译： 使用具有下式（II）的化合物或其药理学上可接受的盐作为P2X4受体拮抗剂：其中R11和R12各自为氢，C1-8烷基等; R 13是氢，C 1-8烷基等; R 14是C 1-8烷氧基，羟基，氰基，任选具有取代基的杂环基等; 并且由W1和相邻的苯环组成的稠环是萘环等。
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公开(公告)号：US20110092703A1
公开(公告)日：2011-04-21
申请号：US12672818
申请日：2008-08-08
申请人： Shogo Sakuma , Tsuyoshi Endo , Noriko Kanakubo , Masahiko Arai , Toshihiro Takahashi , Toshiyasu Imai , Kumiko Taguchi , Eriko Nakata , Nobutaka Mochiduki , Masatoshi Ushioda , Makoto Tsuda , Kazuhide Inoue
发明人： Shogo Sakuma , Tsuyoshi Endo , Noriko Kanakubo , Masahiko Arai , Toshihiro Takahashi , Toshiyasu Imai , Kumiko Taguchi , Eriko Nakata , Nobutaka Mochiduki , Masatoshi Ushioda , Makoto Tsuda , Kazuhide Inoue
IPC分类号： C07D241/04
CPC分类号： A61K31/495 , A61K31/496 , C07D241/04 , C07D405/12
摘要： A P2X4 receptor antagonist is a compound represented by the formula (I) or a pharmacologically acceptable salt thereof, which is used as a preventive or therapeutic agent for neuropathic pains: Wherein B is aryl or the like that can have a substituent; Y is C1-5 alkylene that can have a double bond; Z is O, S or the like; each of R1, R2 and R3 independently is hydrogen, C1-8 alkyl or the like; R4 is hydrogen, C1-8 alkyl or the like; each of P and Q independently is hydrogen, halogen, C1-8 alkyl or the like; W is C1-8 alkyl or the like; and each of n and m independently is 1 or 2.
摘要翻译： P2X4受体拮抗剂是由式（I）表示的化合物或其药理学上可接受的盐，其用作神经性疼痛的预防或治疗剂：其中B是可以具有取代基的芳基等; Y是可具有双键的C 1-5亚烷基; Z是O，S等; R 1，R 2和R 3各自独立地为氢，C 1-8烷基等; R4是氢，C1-8烷基等; P和Q各自独立地是氢，卤素，C 1-8烷基等; W是C 1-8烷基等; n和m各自独立地为1或2。
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公开(公告)号：US20130184459A1
公开(公告)日：2013-07-18
申请号：US13811909
申请日：2011-07-27
IPC分类号： C07D239/70 , C07D403/10
CPC分类号： C07D239/70 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/04 , C07D471/04
摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is C1-8 alkoxy, hydroxyl, cyano, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene ring or the like.
摘要翻译： 使用具有下式（II）的化合物或其药理学上可接受的盐作为P2X4受体拮抗剂：其中R11和R12各自为氢，C1-8烷基等; R 13是氢，C 1-8烷基等; R 14是C 1-8烷氧基，羟基，氰基，任选具有取代基的杂环基等; 并且由W1和相邻的苯环组成的稠环是萘环等。
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公开(公告)号：US08470814B2
公开(公告)日：2013-06-25
申请号：US13148728
申请日：2010-02-15
IPC分类号： C07D403/10 , A61K31/5513 , A61P25/04
CPC分类号： C07D243/10 , C07D403/10 , C07D413/10
摘要： A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, R2 and R3 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a halogen atom, or the like, R4 and R5 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, and W represents tetrazole or the like.
摘要翻译： 作为P2X4受体拮抗剂，使用式（I）表示的二氮平二酮衍生物或其药理学上可接受的盐，其中，R1表示氢原子，碳原子数为1〜8的烷基等，R2，R3表示 氢原子，碳原子数1〜8的烷基，卤素原子等，R4和R5表示氢原子，碳原子数1〜8的烷基等，W表示四唑等 。
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公开(公告)号：US08673915B2
公开(公告)日：2014-03-18
申请号：US13811714
申请日：2011-07-27
IPC分类号： A61K31/498 , C07D241/38
CPC分类号： C07D413/10 , C07D241/38 , C07D241/44 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/12
摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is hydrogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkyl having 1-3 halogens, C1-8 hydroxyalkyl, halogen, hydroxyl, nitro, cyano, amino, C1-8 alkylamino, benzenesulfonylamino optionally having a substituent, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene, tetrahydronaphthalene, or indan ring.
摘要翻译： 使用具有下式（II）的化合物或其药理学上可接受的盐作为P2X4受体拮抗剂：其中R11和R12各自为氢，C1-8烷基等; R 13是氢，C 1-8烷基等; R14是氢，C1-8烷基，C1-8烷氧基，具有1-3个卤素的C1-8烷基，C1-8羟基烷基，卤素，羟基，硝基，氰基，氨基，C1-8烷基氨基，任选具有取代基的苯磺酰基氨基， 任选具有取代基的杂环基等; 由W1和相邻的苯环组成的稠环是萘，四氢萘或茚满环。
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公开(公告)号：US20110319610A1
公开(公告)日：2011-12-29
申请号：US13148728
申请日：2010-02-15
IPC分类号： C07D403/10 , C07D413/10
CPC分类号： C07D243/10 , C07D403/10 , C07D413/10
摘要： A diazepinedione derivative represented by the formula (I) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein R1 represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, R2 and R3 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a halogen atom, or the like, R4 and R5 represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or the like, and W represents tetrazole or the like.
摘要翻译： 作为P2X4受体拮抗剂，使用式（I）表示的二氮平二酮衍生物或其药理学上可接受的盐，其中，R1表示氢原子，碳原子数为1〜8的烷基等，R2，R3表示 氢原子，碳原子数1〜8的烷基，卤素原子等，R4和R5表示氢原子，碳原子数1〜8的烷基等，W表示四唑等 。
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公开(公告)号：US20130217734A1
公开(公告)日：2013-08-22
申请号：US13765540
申请日：2013-02-12
申请人： Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
发明人： Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
IPC分类号： C07D277/22
CPC分类号： C07D277/22 , C07D263/32 , C07D277/20 , C07D277/30 , C07D333/22
摘要： A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like; Aa is thiazole, oxazole, or thiophene, which can have a substituent such as C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like; Ba is a C1-8 alkylene or C2-8 alkenylene chain; and each of R1a and R2a independently is hydrogen, C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like.
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公开(公告)号：US20090298896A1
公开(公告)日：2009-12-03
申请号：US12297436
申请日：2007-04-18
申请人： Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
发明人： Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
IPC分类号： A61K31/426 , C07D277/30 , A61P3/00 , A61P9/10
CPC分类号： C07D277/22 , C07D263/32 , C07D277/20 , C07D277/30 , C07D333/22
摘要： A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like; Aa is thiazole, oxazole, or thiophene, which can have a substituent such as C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like; Ba is a C1-8 alkylene or C2-8 alkenylene chain; and each of R1a and R2a independently is hydrogen, C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like.
摘要翻译： 使用由以下通式（II）表示的化合物或其盐作为PPARδ的活化剂。 其中Ga是O，CH 2等; Aa是噻唑，恶唑或噻吩，其可以具有取代基，例如C 1-8烷基，C 1-8烷氧基，卤素，被卤素取代的C 1-8烷基等; Ba是C 1-8亚烷基或C 2-8亚烯基链; R 1a和R 2a各自独立地为氢，C 1-8烷基，C 1-8烷氧基，卤素，被卤素等取代的C 1-8烷基。
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公开(公告)号：US08404726B2
公开(公告)日：2013-03-26
申请号：US12297436
申请日：2007-04-18
申请人： Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
发明人： Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
IPC分类号： A61K31/426 , C07D277/30 , A61P3/00 , A61P9/10
CPC分类号： C07D277/22 , C07D263/32 , C07D277/20 , C07D277/30 , C07D333/22
摘要： A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like; Aa is thiazole, oxazole, or thiophene, which can have a substituent such as C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like; Ba is a C1-8 alkylene or C2-8 alkenylene chain; and each of R1a and R2a independently is hydrogen, C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like.
摘要翻译： 使用由以下通式（II）表示的化合物或其盐作为PPARδ的活化剂。 其中Ga是O，CH 2等; Aa是噻唑，恶唑或噻吩，其可以具有取代基，例如C 1-8烷基，C 1-8烷氧基，卤素，被卤素取代的C 1-8烷基等; Ba是C 1-8亚烷基或C 2-8亚烯基链; R 1a和R 2a各自独立地为氢，C 1-8烷基，C 1-8烷氧基，卤素，被卤素等取代的C 1-8烷基。
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