摘要:
A P2X4 receptor antagonist is a compound represented by the formula (I) or a pharmacologically acceptable salt thereof, which is used as a preventive or therapeutic agent for neuropathic pains: Wherein B is aryl or the like that can have a substituent; Y is C1-5 alkylene that can have a double bond; Z is O, S or the like; each of R1, R2 and R3 independently is hydrogen, C1-8 alkyl or the like; R4 is hydrogen, C1-8 alkyl or the like; each of P and Q independently is hydrogen, halogen, C1-8 alkyl or the like; W is C1-8 alkyl or the like; and each of n and m independently is 1 or 2.
摘要:
A compound having the following formula (II) or its pharmacologically acceptable salt is used as a P2X4 receptor antagonist: in which R11 represents hydrogen or an alkyl group having 1-8 carbon atoms; R21 represents an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms and having 1-3 halogen substituents, or hydroxyl; and R31 is hydrogen or a halogen atom.
摘要翻译:使用具有下式(II)或其药理学上可接受的盐的化合物作为P2X4受体拮抗剂:其中R11表示氢或具有1-8个碳原子的烷基; R21表示碳原子数1〜8的烷基,碳原子数为1〜8的烷氧基,碳原子数1〜8的烷基,卤素取代基1-3个,羟基, R 31为氢或卤素原子。
摘要:
A compound having the following formula (II) or its pharmacologically acceptable salt is used as a P2X4 receptor antagonist: in which R11 represents hydrogen or an alkyl group having 1-8 carbon atoms; R21 represents an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkyl group having 1-8 carbon atoms and having 1-3 halogen substituents, or hydroxyl; and R31 is hydrogen or a halogen atom.
摘要翻译:使用具有下式(II)或其药理学上可接受的盐的化合物作为P2X4受体拮抗剂:其中R11表示氢或具有1-8个碳原子的烷基; R21表示碳原子数1〜8的烷基,碳原子数为1〜8的烷氧基,碳原子数1〜8的烷基,卤素取代基1-3个,羟基, R 31为氢或卤素原子。
摘要:
A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X4 receptor antagonist: wherein each of R21 and R22 is hydrogen, a C1-8 alkyl group or the like; R23 is hydrogen, a C1-8 alkyl group or the like; each of R24 and R25 is hydrogen, a C1-8 alkyl group or the like; R26 is hydrogen, a C1-8 alkyl group, a halogen atom, hydroxyl, nitro, cyano, phenyl optionally having one or more substituents, or a heterocyclic group optionally having one or more substituents or the like; and p is 0 or 1.
摘要翻译:使用具有下式(III)的二氮杂衍生物或其药理学上可接受的盐作为P2X4受体拮抗剂:其中R21和R22各自为氢,C1-8烷基等; R 23为氢,C 1-8烷基等; R 24和R 25各自为氢,C 1-8烷基等; R 26是氢,C 1-8烷基,卤素原子,羟基,硝基,氰基,任选具有一个或多个取代基的苯基,或任选具有一个或多个取代基的杂环基等; p为0或1。
摘要:
A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X4 receptor antagonist: wherein each of R21 and R22 is hydrogen, a C1-8 alkyl group or the like; R23 is hydrogen, a C1-8 alkyl group or the like; each of R24 and R25 is hydrogen, a C1-8 alkyl group or the like; R26 is hydrogen, a C1-8 alkyl group, a halogen atom, hydroxyl, nitro, cyano, phenyl optionally having one or more substituents, or a heterocyclic group optionally having one or more substituents or the like; and p is 0 or 1.
摘要翻译:使用具有下式(III)的二氮杂衍生物或其药理学上可接受的盐作为P2X4受体拮抗剂:其中R21和R22各自为氢,C1-8烷基等; R 23为氢,C 1-8烷基等; R 24和R 25各自为氢,C 1-8烷基等; R 26是氢,C 1-8烷基,卤素原子,羟基,硝基,氰基,任选具有一个或多个取代基的苯基,或任选具有一个或多个取代基的杂环基等; p为0或1。
摘要:
A turbine rotor which is easy to manufacture and has a high tolerable temperature is provided. A highly efficient steam turbine power plant is also provided. The turbine rotor is configured from a rotor shaft, an inner rotor disc constructed integrally with the rotor shaft, and an outer rotor disc which is welded to the inner rotor disc via a weld metal part and has a structure for fixing a turbine blade. The outer rotor disc preferably has a cooling hole which extends in an axial direction to penetrate the outer rotor disc over the thickness of the outer rotor disc.
摘要:
The present invention is intended to provide a method for assessing remaining lifespan of a bolt with higher precision than conventional methods, which can be applied to a bolt comprising a high alloy with fewer tissue changes caused by creep damage.The present invention provides a method for assessing the remaining lifespan of a bolt used at high temperatures, including: carrying out a creep test for a bolt material that constitutes a bolt to be assessed and determining a life-time and a life-elongation rate; determining a time-temperature parameter based on the life-time and the creep test temperature; creating a lifespan-assessment diagram by plotting the time-temperature parameter with respect to the life-elongation rate; measuring a elongation rate between before and after the use of the bolt to be assessed; and assessing the remaining lifespan of the bolt with the use of the elongation rate between before and after the use of the bolt to be assessed and the lifespan-assessment diagram.
摘要:
A turbine rotor which is easy to manufacture and has a high tolerable temperature is provided. A highly efficient steam turbine power plant is also provided. The turbine rotor is configured from a rotor shaft, an inner rotor disc constructed integrally with the rotor shaft, and an outer rotor disc which is welded to the inner rotor disc via a weld metal part and has a structure for fixing a turbine blade. The outer rotor disc preferably has a cooling hole which extends in an axial direction to penetrate the outer rotor disc over the thickness of the outer rotor disc.
摘要:
A high-strength heat resisting cast steel which has high creep rupture strength at temperatures of 620° C. or above, high toughness, and good weldability. A method of producing the steel, a steam turbine casing, a main steam valve casing, and a steam control valve casing, each casing being made of that steel, as well as a steam turbine power plant using those components are also provided. The high-strength heat resisting cast steel contains 0.06-0.16% by mass of C, 0.1-1% of Si, 0.1-1% of Mn, 8-12% of Cr, 0.1-1.0% of Ni, 0.7% or less of Mo, 1.9-3.0% of W, 0.05-0.3% of V, 0.01-0.15% of one or more of Nb, Ta and Zr in total, 0.1-2% of Co, 0.01-0.08% of N, and 0.0005-0.01% of B, the balance being Fe and unavoidable impurities.
摘要:
The invention is of a heat resisting martensitic steel comprising, by weight, 0.05 to 0.30% C, not more than 0.50% Si, not more than 0.60% Mn, 8.0 to 13.0% Cr, 0.5 to 3.0% Ni, 1.0 to 3.0% Mo, 0.1 to 1.5% W, 0.5 to 4% Co, 0.05 to 0.35% V, 0.02 to 0.30% in total of one or two elements selected from the group consisting of Nb and Ta, and 0.02 to 0.10% N, wherein a value of the square of a difference between the Ni amount and the Co amount, and the Ni amount are not more than values determined by a straight line drawn on a point A (1.0, 2.7%) and a point B (2.5, 1.0%) in the orthogonal coordinates shown in the attached drawing of FIG. 2 which represents a relationship between the above square value and the Ni amount, and an amount ratio of Mo/(Mo+0.5 W) is not less than 0.5. The heat resisting steel is suitably used in various components of a gas turbine.