公开(公告)号：US5164391A

公开(公告)日：1992-11-17

申请号：US582039

申请日：1990-09-13

申请人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Noboru Tomiya ,  Kiichi Sawai ,  Kenji Miura ,  Toshinao Usui ,  Yasuaki Kondo ,  Yukiya Tanaka ,  Shigeyoshi Nakamura ,  Tsunemasa Suzuki ,  Motohide Hayashi

发明人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Noboru Tomiya ,  Kiichi Sawai ,  Kenji Miura ,  Toshinao Usui ,  Yasuaki Kondo ,  Yukiya Tanaka ,  Shigeyoshi Nakamura ,  Tsunemasa Suzuki ,  Motohide Hayashi

IPC分类号： C07D491/10 ,  C07D491/107 ,  C07D495/10

CPC分类号： C07D491/10 ,  C07D495/10

摘要： The invention relates to a hydantoin derivative, salt thereof, process for the preparation thereof, and medicine containing the derivative. The derivative is represented by the formula ##STR1## wherein M is --CONH--NHR.sup.1 group, --CONH--OR.sup.2 group, ##STR2## in which R.sup.1 is hydrogen atom, an alkyl group, an alkenyl group, a phenyl radical, a substituted phenyl group, a naphthyl radical, a substituted naphthyl group, a pyridyl radical, a furyl radical or a thienyl radical, R.sup.2 is a hydrogen atom, an alkyl group, a phenyl radical or a substituted phenyl group, R.sup.3 and R.sup.4 are the same or different independently, each being a phenyl radical, or an aralkyl group, or R.sup.3 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.4 and a possible nitrogen or oxygen atom, R.sup.5 forms a substituted or non-substituted saturated heterocyclic ring together with R.sup.6 and a possible nitrogen or oxygen atom, R.sup.7 is a nitroxy radical or a heteroaryl group, .sub.m and .sub.n are an integer of 2 to 5, Q is a hydrogen atom or ##STR3## in which R.sup.8 and R.sup.9 are the same or different independently, each being a substituted or non-substituted alkyl group, or R.sup.8 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.9 and a possible nitrogen or oxygen atom, .sub.r is an integer of 2 to 5, T and X are the same or different independently, each being a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or an alkylmercapto group, and Z is an oxygen or sulfur atom.The derivatives and salts thereof are useful for the treatment of complications of diabetes and circulatory diseases.

公开(公告)号：US4678801A

公开(公告)日：1987-07-07

申请号：US884125

申请日：1986-07-10

申请人： Masayasu Kurono ,  Motohide Hayashi ,  Tsunemasa Suzuki ,  Kenji Miura ,  Yoshihiro Kumagai ,  Yukiharu Matsumoto ,  Seiji Miyano ,  Kunihiro Sumoto

发明人： Masayasu Kurono ,  Motohide Hayashi ,  Tsunemasa Suzuki ,  Kenji Miura ,  Yoshihiro Kumagai ,  Yukiharu Matsumoto ,  Seiji Miyano ,  Kunihiro Sumoto

IPC分类号： A61K31/40 ,  A61K31/4015 ,  A61P25/28 ,  C07D207/27 ,  C07D487/04 ,  C07D487/06

CPC分类号： C07D487/04

摘要： Novel 2-oxopyrrolidine compounds represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or alkyl group, respectively, A is alkylene group or phenyl substituted alkylene group, and B is alkylene group,or a salt thereof, a process for the preparation thereof, and a pharmaceutical agent comprising the compound or salt as an effective component.

摘要翻译： 由式＆lt; IMAGE＆gt;所示的新型2-氧代吡咯烷化合物，其中R 1和R 2分别为氢或烷基，A为亚烷基或苯基取代的亚烷基，B为亚烷基或其盐，其制备方法 以及包含该化合物或盐作为有效成分的药剂。

公开(公告)号：US5041429A

公开(公告)日：1991-08-20

申请号：US354553

申请日：1989-05-22

申请人： Kiichi Sawai ,  Masayasu Kurono ,  Hiromoto Asai ,  Takahiko Mitani ,  Motohide Hayashi ,  Tunematu Suzuki ,  Naohisa Ninomiya

发明人： Kiichi Sawai ,  Masayasu Kurono ,  Hiromoto Asai ,  Takahiko Mitani ,  Motohide Hayashi ,  Tunematu Suzuki ,  Naohisa Ninomiya

IPC分类号： A61K31/66

CPC分类号： A61K31/66

摘要： Phytic acid or at least one of its salts is used as an effective component for cell activators in a hypoxic state, circulatory ameliorators, dementia remedies and edible compositions.