公开(公告)号：US5164391A

公开(公告)日：1992-11-17

申请号：US582039

申请日：1990-09-13

申请人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Noboru Tomiya ,  Kiichi Sawai ,  Kenji Miura ,  Toshinao Usui ,  Yasuaki Kondo ,  Yukiya Tanaka ,  Shigeyoshi Nakamura ,  Tsunemasa Suzuki ,  Motohide Hayashi

发明人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Noboru Tomiya ,  Kiichi Sawai ,  Kenji Miura ,  Toshinao Usui ,  Yasuaki Kondo ,  Yukiya Tanaka ,  Shigeyoshi Nakamura ,  Tsunemasa Suzuki ,  Motohide Hayashi

IPC分类号： C07D491/10 ,  C07D491/107 ,  C07D495/10

CPC分类号： C07D491/10 ,  C07D495/10

摘要： The invention relates to a hydantoin derivative, salt thereof, process for the preparation thereof, and medicine containing the derivative. The derivative is represented by the formula ##STR1## wherein M is --CONH--NHR.sup.1 group, --CONH--OR.sup.2 group, ##STR2## in which R.sup.1 is hydrogen atom, an alkyl group, an alkenyl group, a phenyl radical, a substituted phenyl group, a naphthyl radical, a substituted naphthyl group, a pyridyl radical, a furyl radical or a thienyl radical, R.sup.2 is a hydrogen atom, an alkyl group, a phenyl radical or a substituted phenyl group, R.sup.3 and R.sup.4 are the same or different independently, each being a phenyl radical, or an aralkyl group, or R.sup.3 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.4 and a possible nitrogen or oxygen atom, R.sup.5 forms a substituted or non-substituted saturated heterocyclic ring together with R.sup.6 and a possible nitrogen or oxygen atom, R.sup.7 is a nitroxy radical or a heteroaryl group, .sub.m and .sub.n are an integer of 2 to 5, Q is a hydrogen atom or ##STR3## in which R.sup.8 and R.sup.9 are the same or different independently, each being a substituted or non-substituted alkyl group, or R.sup.8 may form a substituted or non-substituted C.sub.5-6 saturated heterocyclic ring together with R.sup.9 and a possible nitrogen or oxygen atom, .sub.r is an integer of 2 to 5, T and X are the same or different independently, each being a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or an alkylmercapto group, and Z is an oxygen or sulfur atom.The derivatives and salts thereof are useful for the treatment of complications of diabetes and circulatory diseases.

公开(公告)号：US4897495A

公开(公告)日：1990-01-30

申请号：US351006

申请日：1989-05-12

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Ryoichi Unno ,  Yukiharu Matsumoto ,  Hiromoto Kimura ,  Mitsuru Oka ,  Kiichi Sawai

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Ryoichi Unno ,  Yukiharu Matsumoto ,  Hiromoto Kimura ,  Mitsuru Oka ,  Kiichi Sawai

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： A process for the preparation of pyrrolizine derivatives of the formula ##STR1## wherein R is --CN or --CH.sub.2 NH.sub.2, and salts thereof.

公开(公告)号：US4734411A

公开(公告)日：1988-03-29

申请号：US895099

申请日：1986-08-11

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Toshinao Usui ,  Ryoichi Unno ,  Hiromoto Kimura ,  Masato Fukushima ,  Mitsuru Oka ,  Shinichi Ikeda ,  Noboru Kuboyama ,  Takashi Ito ,  Seiji Miyano ,  Kunihiro Sumoto

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Toshinao Usui ,  Ryoichi Unno ,  Hiromoto Kimura ,  Masato Fukushima ,  Mitsuru Oka ,  Shinichi Ikeda ,  Noboru Kuboyama ,  Takashi Ito ,  Seiji Miyano ,  Kunihiro Sumoto

IPC分类号： A61K31/40 ,  A61K31/54 ,  A61P1/04 ,  C07D487/04 ,  C07D519/00 ,  C07F7/08 ,  A61K31/55 ,  C07D521/00

CPC分类号： C07D487/04 ,  C07F7/0814

摘要： Novel pyrrolizidine compounds represented by the formula ##STR1## wherein R is a radical of ##STR2## R.sup.1 is hydrogen, halogen, alkyl group, alkoxy group, alkanoyl group, trifluoromethyl radical, trimethylsilyl radical or ##STR3## R.sup.2 and R.sup.3 are same or different and are hydrogen or alkyl group, respectively, R.sup.4 is hydrogen, halogen, alkyl group or alkoxy group and m is an integer of 0 to 5,salts thereof, a process for the preparation of same as well as a pharmaceutical agent comprising same.

摘要翻译： 由式（I）表示的新型吡咯烷酮化合物，其中R是R 1的基团是氢，卤素，烷基，烷氧基，烷酰基，三氟甲基，三甲基甲硅烷基或者R 2是 相同或不同，分别为氢或烷基，R4为氢，卤素，烷基或烷氧基，m为0-5的整数，其盐，其制备方法以及药剂，其包含 相同。

公开(公告)号：US5177102A

公开(公告)日：1993-01-05

申请号：US695121

申请日：1991-05-03

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Ryoichi Unno ,  Hiromoto Kimura ,  Noboru Kuboyama ,  Takashi Ito ,  Mitsuru Oka ,  Akira Tashita ,  Kazumasa Nakano ,  Kiichi Sawai

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Takuji Yamaguchi ,  Ryoichi Unno ,  Hiromoto Kimura ,  Noboru Kuboyama ,  Takashi Ito ,  Mitsuru Oka ,  Akira Tashita ,  Kazumasa Nakano ,  Kiichi Sawai

IPC分类号： A61K31/13 ,  A61K31/155 ,  A61P1/04 ,  C07C211/10 ,  C07C211/15 ,  C07C217/46 ,  C07C323/25 ,  C07C323/41 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07C323/25

摘要： There are given disclosures on a polyisoprene compound of the formula ##STR1## wherein Y is S, O, NH or ##STR2## .sub.l is an integer of 2-10, Z is a group of ##STR3## R.sup.1 and R.sup.2 are same or different and each means a hydrogen atom or an alkyl group having C.sub.1-4, m is an integer of 0 or 1, and .sub.n is an integer of 0, 1 or 2,a salt thereof, a process for the preparation of same, and use thereof.

公开(公告)号：US4985569A

公开(公告)日：1991-01-15

申请号：US350990

申请日：1989-05-12

申请人： Masayasu Kurono ,  Yasuaki Kondo ,  Ryoichi Unno ,  Yukiharu Matsumoto ,  Hiromoto Kimura ,  Mitsuru Oka ,  Kiichi Sawai

发明人： Masayasu Kurono ,  Yasuaki Kondo ,  Ryoichi Unno ,  Yukiharu Matsumoto ,  Hiromoto Kimura ,  Mitsuru Oka ,  Kiichi Sawai

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： 7a-Nitromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine of the formula ##STR1## and salts thereof, as well as processes for the preparation of the compound and 7a-aminomethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine and salts thereof.

公开(公告)号：US4871740A

公开(公告)日：1989-10-03

申请号：US124518

申请日：1987-11-24

申请人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Mitsuru Oka ,  Keiko Hasegawa ,  Shinichi Ikeda ,  Noboru Kuboyama ,  Takashi Ito ,  Kiichi Sawai ,  Shunshuke Ito

发明人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Mitsuru Oka ,  Keiko Hasegawa ,  Shinichi Ikeda ,  Noboru Kuboyama ,  Takashi Ito ,  Kiichi Sawai ,  Shunshuke Ito

IPC分类号： C07C69/753 ,  A61K31/56 ,  A61K31/58 ,  A61P1/04 ,  C07C51/367 ,  C07C62/34 ,  C07C62/38 ,  C07C67/00 ,  C07C69/734 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C233/12 ,  C07C235/28 ,  C07C235/40 ,  C07C253/00 ,  C07C255/15 ,  C07C255/23 ,  C07D295/16 ,  C07D295/18

CPC分类号： C07D295/16 ,  A61K31/56 ,  C07C233/12

摘要： A glycyrrhetic acid derivative of the formula ##STR1## wherein X and Y are hydrogen atom, respectively or X is oxygen atom together with Y, A.sub.1 is methylene or carbonyl radical, A.sub.2 is hydrogen atom, cyano, carbamoyl, carboxyl radical or alkoxycarbonyl group, m and n are an integer, respectively, R.sub.1 is a radical of ##STR2## in which R.sub.2 is an alkyl, alkenyl group, phenyl radical or a substituted phenyl radical, A.sub.3 is S, O or NH, and l is an integer, a process for the preparation of the derivatives, and use of the derivative as a pharmaceutical agent.

公开(公告)号：US4868189A

公开(公告)日：1989-09-19

申请号：US140503

申请日：1988-01-04

申请人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Hiroshi Ozawa ,  Takahiko Mitani ,  Takahito Jomori ,  Masahiko Koketsu ,  Hisashi Michishita ,  Kiichi Sawai

发明人： Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Hiroshi Ozawa ,  Takahiko Mitani ,  Takahito Jomori ,  Masahiko Koketsu ,  Hisashi Michishita ,  Kiichi Sawai

IPC分类号： C07F7/10 ,  A61K31/695 ,  A61P35/00 ,  C07F7/08 ,  C07F7/18

CPC分类号： C07F7/0812

摘要： An organo-silicone compound of the formula ##STR1## wherein X is a methylene or carbonyl radical, Y is an NH or O, n is an integer, R.sub.1 is a hydrogen atom, halogen atom or alkyl group, R.sub.2, R.sub.3 and R.sub.4 are an alkyl group, alkoxy group, phenyl radical or substituted phenyl radical, respectively, and R.sub.5 is a hydrogen atom or a group of ##STR2## in which X, Y, n, R.sub.2, R.sub.3 and R.sub.4 have the meanings as referred to, and used as an anti-tumor agent or for use in anti-tumor compositions.

公开(公告)号：US5356880A

公开(公告)日：1994-10-18

申请号：US889709

申请日：1992-05-28

申请人： Masayasu Kurono ,  Yoshiro Ishiwata ,  Syoji Yokochi ,  Kyoichi Asano ,  Takahiko Mitani ,  Takuji Kakigami ,  Noriyuki Iwata ,  Kougaku Isogawa ,  Yutaka Baba ,  Hiroyuki Ohwaki ,  Kiichi Sawai ,  Hiromoto Kimura ,  Masato Fukushima ,  Ryoichi Unno ,  Tamaki Ohtuka

发明人： Masayasu Kurono ,  Yoshiro Ishiwata ,  Syoji Yokochi ,  Kyoichi Asano ,  Takahiko Mitani ,  Takuji Kakigami ,  Noriyuki Iwata ,  Kougaku Isogawa ,  Yutaka Baba ,  Hiroyuki Ohwaki ,  Kiichi Sawai ,  Hiromoto Kimura ,  Masato Fukushima ,  Ryoichi Unno ,  Tamaki Ohtuka

IPC分类号： C07C61/35 ,  C07C62/38 ,  C07C323/41 ,  C07D295/185 ,  C07H15/256 ,  C07J63/00 ,  A61K31/58 ,  C07J43/00

CPC分类号： C07D295/185 ,  C07C323/41 ,  C07C61/35 ,  C07C62/38 ,  C07H15/256 ,  C07J63/008 ,  C07C2103/52

摘要： The invention provides a novel glycoside which contains as the aglycon a 4-(substituted phenyl)piperazine-1-yl derivative of glycyrrhetinic acid and 11-deoxo-glycyrrhetinic acid or their derivative as well as a composition for the treatment of virus infection, which contains these compounds as a main active component.

摘要翻译： 本发明提供了一种新颖的糖苷，其含有作为糖苷配基的甘草次酸和11-脱氧甘草次酸或其衍生物的4-（取代苯基）哌嗪-1-基衍生物以及用于治疗病毒感染的组合物，其中 含有这些化合物作为主要活性组分。

公开(公告)号：US4778797A

公开(公告)日：1988-10-18

申请号：US773967

申请日：1985-09-09

申请人： Shigeshi Toyoshima ,  Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Koichi Ito

发明人： Shigeshi Toyoshima ,  Masayasu Kurono ,  Ryoichi Unno ,  Hiromoto Kimura ,  Koichi Ito

IPC分类号： A61K31/695 ,  A61P35/00 ,  C07F7/08 ,  C07F7/10 ,  C07F7/18

CPC分类号： C07F7/0812

摘要： Novel organo-silicone compounds represented by the formula, ##STR1## wherein R is hydrogen, halogen or alkyl group, R.sup.1, R.sup.2 and R.sup.3 are alkyl group, alkoxy group, phenyl radical, substituted phenyl radical, alkylcarbonyloxy group, or trialkylsilyloxy group, respectively, R.sup.4 is hydrogen, alkyl or alkenyl grup, and m and n are an integer, respectively but those do not represent same integer of 2, when all of R.sup.1, R.sup.2 and R.sup.3 represents methyl radical, a process for the manufacture of the compounds, and an anti-tumor agent which comprises as an effective component, at least one of the compounds.

摘要翻译： 其中R为氢，卤素或烷基，R1，R2和R3分别为烷基，烷氧基，苯基，取代苯基，烷基羰基氧基或三烷基甲硅烷氧基的新型有机硅氧烷化合物， R 4为氢，烷基或链烯基，并且m和n分别为整数，但当R 1，R 2和R 3全部为甲基时，它们不表示2的整数，制备该化合物的方法， 和包含作为有效成分的至少一种化合物的抗肿瘤剂。