公开(公告)号：US08268613B2

公开(公告)日：2012-09-18

申请号：US12761221

申请日：2010-04-15

申请人： Masayuki Naya ,  Takashi Kubo ,  Takashi Ito ,  Yoshimitsu Nomura

发明人： Masayuki Naya ,  Takashi Kubo ,  Takashi Ito ,  Yoshimitsu Nomura

IPC分类号： C12M1/34

CPC分类号： G01N21/553 ,  B29C45/0025 ,  B29C2045/0027 ,  G01N2201/0415

摘要： A surface plasmon resonance measuring apparatus is provided with a dielectric block, a metal film formed on a surface of the dielectric block, a light source for emitting a light beam, an optical system for making the light beam enter the dielectric block at various angles of incidence so that a condition for total internal reflection is satisfied at an interface between the dielectric block and the thin film layer, and a photodetector for detecting the intensity of the light beam satisfying total internal reflection at the interface. In the measurement chip to be utilized in the surface plasmon resonance measuring apparatus, the dielectric block is formed from a synthetic resin in which, when said light beam is p-polarized outside said dielectric block and then strikes the interface, the intensity of a s-polarized component at the interface is 50% or less of the intensity of the light beam at the interface.

摘要翻译： 表面等离子体共振测定装置具备介质块，形成在介质块的表面上的金属膜，用于发射光束的光源，使光束以各种角度进入介质块的光学系统 入射，使得在介电块和薄膜层之间的界面处满足全内反射条件，以及用于检测在界面处满足全内反射的光束的强度的光电检测器。 在表面等离子体共振测定装置中使用的测量芯片中，介电块由合成树脂形成，其中当所述光束在所述介质块外部p偏振，然后撞击界面时，s的强度 界面处的极化分量为界面光束强度的50％以下。

公开(公告)号：US20100195107A1

公开(公告)日：2010-08-05

申请号：US12761221

申请日：2010-04-15

申请人： Masayuki Naya ,  Takashi Kubo ,  Takashi Ito ,  Yoshimitsu Nomura

发明人： Masayuki Naya ,  Takashi Kubo ,  Takashi Ito ,  Yoshimitsu Nomura

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  B29C45/0025 ,  B29C2045/0027 ,  G01N2201/0415

摘要： A surface plasmon resonance measuring apparatus is provided with a dielectric block, a metal film formed on a surface of the dielectric block, a light source for emitting a light beam, an optical system for making the light beam enter the dielectric block at various angles of incidence so that a condition for total internal reflection is satisfied at an interface between the dielectric block and the thin film layer, and a photodetector for detecting the intensity of the light beam satisfying total internal reflection at the interface. In the measurement chip to be utilized in the surface plasmon resonance measuring apparatus, the dielectric block is formed from a synthetic resin in which, when said light beam is p-polarized outside said dielectric block and then strikes the interface, the intensity of a s-polarized component at the interface is 50% or less of the intensity of the light beam at the interface.

摘要翻译： 表面等离子体共振测定装置具备介质块，形成在介质块的表面上的金属膜，用于发射光束的光源，使光束以各种角度进入介质块的光学系统 入射，使得在介电块和薄膜层之间的界面处满足全内反射条件，以及用于检测在界面处满足全内反射的光束的强度的光电检测器。 在表面等离子体共振测定装置中使用的测量芯片中，介电块由合成树脂形成，其中当所述光束在所述介质块外部p偏振，然后撞击界面时，s的强度 界面处的极化分量为界面光束强度的50％以下。

公开(公告)号：US06864984B2

公开(公告)日：2005-03-08

申请号：US09959645

申请日：2001-03-14

申请人： Masayuki Naya ,  Takashi Kubo ,  Nobuhiko Ogura ,  Nobufumi Mori

发明人： Masayuki Naya ,  Takashi Kubo ,  Nobuhiko Ogura ,  Nobufumi Mori

IPC分类号： G01N21/55 ,  G01N21/27

CPC分类号： G01N21/553

摘要： A plurality of measuring units each comprising a dielectric block, a metal film layer which is formed on a surface of the dielectric block and a sample holder are supported on a support. The support is moved by a support drive means to bring in sequence the measuring units to a measuring portion comprising an optical system which projects a light beam emitted from a light source, and a photodetector which detects attenuation in total internal reflection by detecting the intensity of the light beam which is reflected in total internal reflection at the interface between the dielectric block and the metal film layer. In this measuring apparatus, lots of samples can be measured in a short time.

摘要翻译： 多个测量单元，每个测量单元包括介质块，形成在介质块的表面上的金属膜层和样品保持器支撑在支撑体上。 支撑体通过支撑驱动装置移动，以将测量单元顺序地调节到包括投影从光源发射的光束的光学系统的测量部分，以及通过检测全部内部反射的强度来检测全内反射的衰减的光电检测器 所述光束在介电块和金属膜层之间的界面处被反射在全内反射中。 在该测量装置中，可以在短时间内测量许多样品。

公开(公告)号：US06597456B2

公开(公告)日：2003-07-22

申请号：US09851957

申请日：2001-05-10

申请人： Takashi Kubo ,  Masayuki Naya

发明人： Takashi Kubo ,  Masayuki Naya

IPC分类号： G01N2155

CPC分类号： G01N21/553 ,  G01N2201/0415

摘要： A measuring apparatus includes a dielectric block, a film layer which is formed on a first face of the dielectric block and is brought into contact with a sample, an optical system which causes a light beam to enter the dielectric block through a second face so that the light beam is reflected in total internal reflection at the interface of the dielectric block and the film layer and various angles of incidence of the light beam to the interface can be obtained, and a photodetector which detects the intensity of the light beam which is reflected in total internal reflection at the interface and goes outside the dielectric block through a third face thereof. A measuring chip includes a single dielectric block having all the first to third faces and the film layer integrally formed on the first face of the dielectric block.

摘要翻译： 测量装置包括介质块，形成在介质块的第一面上并与样品接触的膜层，使得光束通过第二面进入介质块的光学系统，使得 光束在介质块和膜层的界面处的全反射中被反射，并且可以获得光束到界面的各种入射角，以及检测被反射的光束的强度的光电检测器 在界面处的全内反射，并通过其第三面向外介质块。 测量芯片包括具有所有第一至第三表面的单个介质块和整体形成在介质块的第一面上的膜层。

公开(公告)号：US08044344B2

公开(公告)日：2011-10-25

申请号：US12409146

申请日：2009-03-23

申请人： Masayuki Naya ,  Yuichi Tomaru ,  Naoki Murakami

发明人： Masayuki Naya ,  Yuichi Tomaru ,  Naoki Murakami

IPC分类号： B01D59/44

CPC分类号： H01J49/164

摘要： A mass spectroscope includes a mass analysis device having a surface provided with metallic members capable of exciting plasmons when irradiated by laser light, the mass analysis device allowing an analyte to be attached to the surface, a light radiation unit for irradiating the surface of the mass analysis device with laser light to ionize the analyte attached to the surface and desorb the analyte from the surface, and a detection unit for detecting a mass of the analyte ionized and desorbed from the surface of the mass analysis device from a time of flight of the analyte. The light radiation unit includes a polarization adjusting mechanism for adjusting a polarization direction of the laser light.

摘要翻译： 质谱仪包括质量分析装置，其具有设置有能够激发等离子体激元的金属构件的表面，所述金属构件能够在被激光照射时激发等离子体，所述质量分析装置使分析物附着在所述表面上，所述质量分析装置用于照射所述质量的表面 分析装置，其具有激光以电离附着在表面上的分析物并从表面解吸分析物;以及检测单元，用于检测从质量分析装置的表面离子化和解吸的分析物质量， 分析物。 光辐射单元包括用于调节激光的偏振方向的偏振调节机构。

公开(公告)号：US07812957B2

公开(公告)日：2010-10-12

申请号：US12360740

申请日：2009-01-27

申请人： Takeharu Tani ,  Masayuki Naya

发明人： Takeharu Tani ,  Masayuki Naya

IPC分类号： G01N21/55

CPC分类号： G01N21/553

摘要： A measurement apparatus includes a dielectric block, a thin film layer formed on the dielectric block and brought into contact with a sample, a light source for generating a light beam, an optical incident system for causing the light beam to enter the dielectric block so that the light beam is totally reflected at the interface between the dielectric block and the thin film, and a two-dimensional light detection means for detecting the intensity of the light beam totally reflected at the interface. A predetermined pattern is formed within a region irradiated with the light beam on the dielectric block. The measurement apparatus includes a correction means for correcting an output from the two-dimensional light detection means, based on the pattern, so that an object on the face of the dielectric block is similar to the object detected by the two-dimensional detection means.

摘要翻译： 测量装置包括介质块，形成在介质块上并与样品接触的薄膜层，用于产生光束的光源，用于使光束进入介质块的光入射系统，使得 所述光束在所述介质块和所述薄膜之间的界面处被全反射，以及二维光检测装置，用于检测在所述界面处全反射的光束的强度。 在介质块上用光束照射的区域内形成预定图案。 测量装置包括校正装置，用于根据图案校正来自二维光检测装置的输出，使得介质块的表面上的物体类似于由二维检测装置检测的物体。

公开(公告)号：US20090273780A1

公开(公告)日：2009-11-05

申请号：US12434147

申请日：2009-05-01

申请人： Yuichi Tomaru ,  Naoki Murakami ,  Masayuki Naya

发明人： Yuichi Tomaru ,  Naoki Murakami ,  Masayuki Naya

IPC分类号： G01J3/44

CPC分类号： G01N21/658

摘要： A Raman spectrum detecting method includes a liquid sample contacting step of placing a liquid sample containing a reference substance and a specimen in contact with a detection surface, the reference substance generating a known Raman spectrum having at least one peak therein that is different from peaks in a Raman spectrum generated by the specimen; a scattered light detecting step of irradiating the detection surface in contact with the liquid sample with an excitation light and detecting Raman scattered light occurring from the liquid sample; and a normalizing step of extracting a Raman spectrum signal of the reference substance and a Raman spectrum signal of the specimen from the signal detected in the scattered light detecting step and normalizing a signal intensity of the Raman spectrum signal of the specimen according to an intensity of the Raman spectrum signal of the reference substance.

摘要翻译： 拉曼光谱检测方法包括液体样品接触步骤，其将含有参考物质和样品的液体样品放置在与检测表面接触的位置，所述参考物质产生已知的拉曼光谱，其具有与其中的峰不同的至少一个峰 样品产生的拉曼光谱; 散射光检测步骤，用激发光照射与液体样品接触的检测表面，并检测从液体样品发生的拉曼散射光; 以及归一化步骤，从根据在散射光检测步骤中检测到的信号中提取参考物质的拉曼光谱信号和样品的拉曼光谱信号，并根据样品的拉曼光谱信号的强度对样品的拉曼光谱信号的信号强度进行归一化 参考物质的拉曼光谱信号。

公开(公告)号：US20090252002A1

公开(公告)日：2009-10-08

申请号：US12457328

申请日：2009-06-08

申请人： Kiichi Ueyanagi ,  Masayuki Naya ,  Yuichi Tomaru

发明人： Kiichi Ueyanagi ,  Masayuki Naya ,  Yuichi Tomaru

IPC分类号： G11B11/00

CPC分类号： G11B7/1387

摘要： A near-field light-emitting element includes a transparent medium having a plane of incidence into which a laser beam enters, and a light-condensing plane on which the laser beam having entered the plane of incidence is concentrated, and a metal body provided on the light-condensing plane of the transparent medium having a first surface contacting the light-condensing plane, a second surface opposing the first surface, and an aperture which is formed to penetrate through the first and second surfaces at a position where the laser beam is concentrated and which emits a near-field light obtained from the laser beam. The metal body is arranged apart from a center of the aperture by a predetermined distance to connect together the first and second surfaces, and has a plasmon reflection plane that reflects toward the aperture a surface plasmon excited on the first and second surfaces by the laser beam concentrated at the aperture.

摘要翻译： 近场发光元件包括具有激光束入射的入射面的透明介质和进入入射平面的激光束集中的聚光面，以及设置在其上的金属体 所述透明介质的聚光面具有与所述聚光面接触的第一表面，与所述第一表面相对的第二表面，以及形成为穿过所述第一表面和所述第二表面的孔， 并且发射从激光束获得的近场光。 金属体与孔径的中心隔开预定的距离，以将第一和第二表面连接在一起，并且具有等离子体反射面，该等离子体反射面通过激光​​束向孔径反射在第一和第二表面上激发的表面等离子体激元 集中在光圈。

公开(公告)号：US20060194151A1

公开(公告)日：2006-08-31

申请号：US11327521

申请日：2006-01-09

申请人： Yoshio Inagaki ,  Masayuki Naya

发明人： Yoshio Inagaki ,  Masayuki Naya

IPC分类号： G11B7/24

CPC分类号： B82Y10/00 ,  G11B7/00455 ,  G11B7/0052 ,  G11B7/1384 ,  G11B7/244 ,  G11B7/247 ,  G11B7/259 ,  G11B7/2595 ,  G11B2007/24624

摘要： A recording medium comprises a substrate and a recording layer overlaid on the substrate. The recording layer comprises a material, which has properties such that, when recording light having a predetermined wavelength λ1 is irradiated to the material, the material is capable of being caused to change into a fluorescent material and such that, when excitation light having a wavelength λ2 is then irradiated to the thus formed fluorescent material, the fluorescent material is capable of being caused to produce fluorescence. The wavelength λ1 of the recording light and the wavelength λ2 of the excitation light may be identical or different. The substrate may be constituted of a material having properties such that, when the excitation light is irradiated to the material, the material does not produce fluorescence having a wavelength identical with the wavelength of the fluorescence produced by the fluorescent material.

摘要翻译： 记录介质包括衬底和覆盖在衬底上的记录层。 记录层包括一种材料，其具有这样的特性，即当记录具有预定波长λ1的光被照射到材料时，该材料能够变成荧光材料，并且使得当具有 然后将波长λ2照射到如此形成的荧光材料上，荧光材料能够产生荧光。 记录光的波长λ1和激发光的波长λ2可以相同或不同。 衬底可以由具有这样的特性的材料构成，即当激发光照射到材料时，材料不产生具有与由荧光材料产生的荧光的波长相同的波长的荧光。

公开(公告)号：US07058001B2

公开(公告)日：2006-06-06

申请号：US09793721

申请日：2001-02-27

申请人： Yoshio Inagaki ,  Masayuki Naya

发明人： Yoshio Inagaki ,  Masayuki Naya

IPC分类号： G11B7/24

CPC分类号： B82Y10/00 ,  G11B7/00455 ,  G11B7/0052 ,  G11B7/1384 ,  G11B7/244 ,  G11B7/247 ,  G11B7/259 ,  G11B7/2595 ,  G11B2007/24624

摘要： A recording medium comprises a substrate and a recording layer overlaid on the substrate. The recording layer comprises a material, which has properties such that, when recording light having a predetermined wavelength λ1 is irradiated to the material, the material is capable of being caused to change into a fluorescent material and such that, when excitation light having a wavelength λ2 is then irradiated to the thus formed fluorescent material, the fluorescent material is capable of being caused to produce fluorescence. The wavelength λ1 of the recording light and the wavelength λ2 of the excitation light may be identical or different. The substrate may be constituted of a material having properties such that, when the excitation light is irradiated to the material, the material does not produce fluorescence having a wavelength identical with the wavelength of the fluorescence produced by the fluorescent material.