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Patent Agency Ranking
公开(公告)号：US20230053902A1
公开(公告)日：2023-02-23
申请号：US17690876
申请日：2022-03-09
Inventor： J. Christopher Love , Kerry R. Love , Laura Crowell , Alan Stockdale , Richard Dean Braatz , Amos Enshen Lu , Steven Cramer , Steven Timmick , Nicholas Vecchiarello , Chaz Goodwine , Craig A. Mascarenhas
Abstract: Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments; these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.
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2.发明申请公开(公告)号：US20200251186A1
公开(公告)日：2020-08-06
申请号：US16499776
申请日：2018-03-30
Inventor： J. Christopher Love , Kerry R. Love , Steven Cramer , Steven Timmick , Nicholas Vecchiarello , Chaz Goodwine , Laura Crowell , Alan Stockdale , Richard Dean Braatz , Amos Enshen Lu
Abstract: Systems and methods for generating and evaluating candidate sequences of partitioning steps to partition at least one biologically produced product from at least one impurity. In some embodiments, a plurality of candidate sequences of partitioning steps may be generated, wherein at least one candidate sequence of the plurality of candidate sequences comprises a plurality of partitioning steps in a specified order. The plurality of candidate sequences may be evaluated. For instance, a data set associated with the at least one partitioning step may be accessed, the data set comprising: first data indicative of a behavior of the at least one biologically produced product with respect to the at least one partitioning step; and second data indicative of a behavior of the at least one impurity with respect to the at least one partitioning step. The at least one candidate sequence may be scored based at least in part on the data set.
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公开(公告)号：US20190070564A1
公开(公告)日：2019-03-07
申请号：US16120200
申请日：2018-08-31
Applicant: Massachusetts Institute of Technology
Inventor： J. Christopher Love , Craig A. Mascarenhas , Amos Enshen Lu , Richard Dean Braatz
Abstract: Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).
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公开(公告)号：US10987636B2
公开(公告)日：2021-04-27
申请号：US16120200
申请日：2018-08-31
Applicant: Massachusetts Institute of Technology
Inventor： J. Christopher Love , Craig A. Mascarenhas , Amos Enshen Lu , Richard Dean Braatz
Abstract: Aspects of the present disclosure relate to filtration systems and methods for production of biologically-produced products, which may include pharmaceutical and/or protein products. Certain biomanufacturing systems described herein comprise a bioreactor (e.g., a perfusion bioreactor, a chemostat) and a filter probe comprising a filter bundle comprising a plurality of hollow fibers (e.g., longitudinally aligned hollow fibers). According to some embodiments, a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is relatively large (e.g., greater than or equal to an average outer diameter of the hollow fibers of the fiber bundle, greater than or equal to 1.1 times a minimum diameter of the two hollow fibers). In some embodiments, the hollow fibers within the fiber bundle are arranged in an array (e.g., a hexagonal, linear, annular, or square array).
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公开(公告)号：US20200224144A1
公开(公告)日：2020-07-16
申请号：US16499780
申请日：2018-03-30
Inventor： J. Christopher Love , Kerry R. Love , Laura Crowell , Alan Stockdale , Richard Dean Braatz , Amos Enshen Lu , Steven Cramer , Steven Timmick , Nicholas Vecchiarello , Chaz Goodwine , Craig A. Mascarenhas
Abstract: Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments, these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.
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