公开(公告)号：US10449267B2

公开(公告)日：2019-10-22

申请号：US14540872

申请日：2014-11-13

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Chao Zhong

IPC: C07K14/78 ,  C08H1/00 ,  C09J189/00 ,  A61L24/10 ,  C07K14/245 ,  C07K14/435 ,  D01F4/00 ,  C09J5/00 ,  A61L24/00

Abstract: Compositions, methods, and kits are provided which involve novel fusion protein-based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an adhesive domain (e.g., derived from an adhesive protein of a marine organism) and an amyloid domain (e.g., derived from a bacterial amyloid protein). Also provided are copolymers and fibers of the fusion proteins.

公开(公告)号：US20160220727A1

公开(公告)日：2016-08-04

申请号：US14540872

申请日：2014-11-13

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Chao Zhong

IPC: A61L24/10 ,  C07K14/245 ,  A61L24/00 ,  C07K14/435

Abstract: Compositions, methods, and kits are provided which involve novel fusion protein-based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an adhesive domain (e.g., derived from an adhesive protein of a marine organism) and an amyloid domain (e.g., derived from a bacterial amyloid protein). Also provided are copolymers and fibers of the fusion proteins.

Abstract translation: 提供了组合物，方法和试剂盒，其包括用于医疗和海洋应用的新的基于融合蛋白的粘合剂。 在一些方面，新型融合蛋白包含粘合剂结构域（例如衍生自海洋生物的粘合蛋白）和淀粉样蛋白结构域（例如衍生自细菌淀粉样蛋白）。 还提供了融合蛋白的共聚物和纤维。