公开(公告)号：US20200009256A1

公开(公告)日：2020-01-09

申请号：US16502551

申请日：2019-07-03

Applicant: Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  Owen Shea Fenton ,  Jason Andresen ,  Marion Paolini

IPC: A61K47/34 ,  C08G65/00 ,  A61L27/18 ,  A61L27/38 ,  A61K9/06 ,  A61L27/52

Abstract: Provided herein are polymers of Formula (I), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, compositions, and formulations thereof. The polymers described herein are biocompatible, non-toxic, water compatible, and operationally simple to formulate. Also provided are methods and kits involving the polymers described herein (e.g., methods of using polymers described herein for delivering agents (e.g., for therapeutic, diagnostic, prophylactic, imaging, ophthalmic, intraoperative, or cosmetic use) to a subject, cell, tissue, or biological sample, as part of materials (e.g., biodegradable materials, biocompatible materials, wound dressing (e.g., bandages), drug depots, coatings), or as scaffolds for tissue engineering. Provided are methods for synthesizing the polymers described herein, and polymers described herein synthesized by the synthetic methods described herein.

公开(公告)号：US20240316216A1

公开(公告)日：2024-09-26

申请号：US18698888

申请日：2022-10-06

Applicant: Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  Li-Huei Tsai ,  Owen Shea Fenton ,  Joel Blanchard ,  Jason Andresen ,  Julia Bonner ,  William Ralvenius

IPC: A61K48/00 ,  A61K47/14 ,  A61K47/28

CPC classification number: A61K48/0033 ,  A61K47/14 ,  A61K47/28 ,  A61K48/0058

Abstract: Provided herein are methods of selectively delivering an agent to a cell, comprising contacting the cell with a composition comprising an agent and lipids selected from: (a) an ionizable amino lipid, (b) a sterol, (c) a phospholipid, and (d) a PEG-lipid. The methods are selective for delivery to microglia over other neuroglia, such as astrocytes.

公开(公告)号：US11491228B2

公开(公告)日：2022-11-08

申请号：US16502551

申请日：2019-07-03

Applicant: Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  Owen Shea Fenton ,  Jason Andresen ,  Marion Paolini

IPC: A61K47/34 ,  A61K9/06 ,  A61L27/18 ,  A61L27/38 ,  A61L27/52 ,  C08G65/00 ,  C08G18/64

Abstract: Provided herein are polymers of Formula (I), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, compositions, and formulations thereof. The polymers described herein are biocompatible, non-toxic, water compatible, and operationally simple to formulate. Also provided are methods and kits involving the polymers described herein (e.g., methods of using polymers described herein for delivering agents (e.g., for therapeutic, diagnostic, prophylactic, imaging, ophthalmic, intraoperative, or cosmetic use) to a subject, cell, tissue, or biological sample, as part of materials (e.g., biodegradable materials, biocompatible materials, wound dressing (e.g., bandages), drug depots, coatings), or as scaffolds for tissue engineering. Provided are methods for synthesizing the polymers described herein, and polymers described herein synthesized by the synthetic methods described herein.