公开(公告)号：US20240316216A1

公开(公告)日：2024-09-26

申请号：US18698888

申请日：2022-10-06

Applicant: Massachusetts Institute of Technology

Inventor： Robert S. Langer ,  Li-Huei Tsai ,  Owen Shea Fenton ,  Joel Blanchard ,  Jason Andresen ,  Julia Bonner ,  William Ralvenius

IPC: A61K48/00 ,  A61K47/14 ,  A61K47/28

CPC classification number: A61K48/0033 ,  A61K47/14 ,  A61K47/28 ,  A61K48/0058

Abstract: Provided herein are methods of selectively delivering an agent to a cell, comprising contacting the cell with a composition comprising an agent and lipids selected from: (a) an ionizable amino lipid, (b) a sterol, (c) a phospholipid, and (d) a PEG-lipid. The methods are selective for delivery to microglia over other neuroglia, such as astrocytes.

公开(公告)号：US20210353566A1

公开(公告)日：2021-11-18

申请号：US17318921

申请日：2021-05-12

Applicant: Massachusetts Institute of Technology ,  Whitehead Institute for Biomedical Research

Inventor： Li-Huei Tsai ,  Yuan-Ta Lin ,  Julia Bonner ,  Priyanka Narayan ,  Grzegorz Sienski

IPC: A61K31/14 ,  A61P25/28 ,  A61P3/06

Abstract: The invention relates to methods of using choline supplementation for treating APOE4-related disorders. In particular the methods are accomplished by administering choline treatment paradigms to re-establish lipid homeostasis in APOE4 carriers.