公开(公告)号：US11318293B2

公开(公告)日：2022-05-03

申请号：US16696233

申请日：2019-11-26

Applicant: Massachusetts Institute of Technology

Inventor： Michael S. Williams ,  Jason Siu Wei Li ,  Jacob Coffey ,  Christoph Winfried Johannes Steiger ,  Miguel Jimenez ,  Robert S. Langer ,  Ester Caffarel Salvador ,  Alex Abramson ,  Carlo Giovanni Traverso

IPC: A61M37/00 ,  A01K11/00

Abstract: A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.

公开(公告)号：US20200164193A1

公开(公告)日：2020-05-28

申请号：US16696233

申请日：2019-11-26

Applicant: Massachusetts Institute of Technology

Inventor： Michael S. Williams ,  Jason Siu Wei Li ,  Jacob Coffey ,  Christoph Winfried Johannes Steiger ,  Miguel Jimenez ,  Robert S. Langer ,  Ester Caffarel Salvador ,  Alex Abramson

IPC: A61M37/00 ,  A01K11/00

Abstract: A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.