公开(公告)号：US20190002912A1

公开(公告)日：2019-01-03

申请号：US15737829

申请日：2016-06-17

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Lior Nissim ,  Ming-Ru Wu

IPC: C12N15/85 ,  C07K14/47 ,  C07K16/32 ,  C07K16/28

Abstract: Aspects of the present disclosure provide a platform that triggers potent and effective immunotherapy against tumors from within tumors themselves, thus overcoming limitations of existing cancer immunotherapies and tumor-detecting gene circuits.

公开(公告)号：US11718860B2

公开(公告)日：2023-08-08

申请号：US16493340

申请日：2018-03-13

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Lior Nissim ,  Ming-Ru Wu

IPC: A01N63/00 ,  A61K39/245 ,  C07H21/04 ,  C12N15/85 ,  A61K35/763 ,  C12N15/86

CPC classification number: C12N15/85 ,  A61K35/763 ,  C12N15/86 ,  C12N2710/16632 ,  C12N2710/16643 ,  C12N2830/008

Abstract: Synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells) are described. The synthetic promoters may be used to drive expression of gene(s) of interest in a specific cell type or during a specific cellular state. These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.

公开(公告)号：US20210171977A1

公开(公告)日：2021-06-10

申请号：US16493340

申请日：2018-03-13

Applicant: Massachusetts Institute of Technology

Inventor： Timothy Kuan-Ta Lu ,  Lior Nissim ,  Ming-Ru Wu

IPC: C12N15/85 ,  C12N15/86 ,  A61K35/763

Abstract: Aspects of the present disclosure provide synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells). These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.