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Patent Agency Ranking
公开(公告)号：US20200348502A1
公开(公告)日：2020-11-05
申请号：US16694270
申请日：2019-11-25
Applicant: Massachusetts Institute of Technology
Inventor： Young-Gyu Yoon , Zeguan Wang , Nikita Pak , Edward Boyden
Abstract: A light field microscope may record a raw light field video of a sample. The raw video recording may be decomposed into a non-negative low-rank component and a non-negative sparse component. The low-rank component may correspond to a static portion of the sample, and the sparse component may correspond to a dynamically changing portion of the sample. Volume reconstruction may be performed on the sparse component to generate a three-dimensional video of the sample, with improved spatial resolution. In some cases, the decomposition is calculated by an alternating direction method of multipliers algorithm, with the non-negativity of the sparse component and low-rank component enforced after each iteration. In some cases, the volume reconstruction is calculated by Richardson-Lucy iteration with regularization. The sample may be fluorescent. The fluorescence may be indicative of neural activity in the sample.
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公开(公告)号：US20210298769A1
公开(公告)日：2021-09-30
申请号：US17088494
申请日：2020-11-03
Applicant: Massachusetts Institute of Technology
Inventor： Nikita Pak , Justin P. Kinney , Edward S. Boyden
Abstract: An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that automatically controls the drilling apparatus, the positioning device, and the detection device. A method for automated opening of craniotomies includes, under automatice control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. Determining conductance may include use of an impedance detection circuit.
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公开(公告)号：US11564701B2
公开(公告)日：2023-01-31
申请号：US17088494
申请日：2020-11-03
Applicant: Massachusetts Institute of Technology
Inventor： Nikita Pak , Justin P. Kinney , Edward S. Boyden
Abstract: An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that automatically controls the drilling apparatus, the positioning device, and the detection device. A method for automated opening of craniotomies includes, under automatic control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. Determining conductance may include use of an impedance detection circuit.
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公开(公告)号：US10820914B2
公开(公告)日：2020-11-03
申请号：US15096256
申请日：2016-04-11
Applicant: Massachusetts Institute of Technology
Inventor： Nikita Pak , Justin P. Kinney , Edward S. Boyden
Abstract: A method for automated opening of craniotomies includes, under the control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that controls the drilling apparatus, the positioning device, and the detection device according to the method. Determining conductance may include use of an impedance detection circuit.
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5.发明申请公开(公告)号：US20160296242A1
公开(公告)日：2016-10-13
申请号：US15096256
申请日：2016-04-11
Applicant: Massachusetts Institute of Technology
Inventor： Nikita Pak , Justin P. Kinney , Edward S. Boyden
Abstract: A method for automated opening of craniotomies includes, under the control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. A craniotomy pattern may be predetermined and automatically drilled under control of the processor. A cranial window may be created by drilling along a path that interpolates between holes to form the circumference of the window. An automated craniotomy opening apparatus includes a drilling apparatus with a drilling tip, at least one drilling apparatus positioning device, a detection device, and a computer processor that controls the drilling apparatus, the positioning device, and the detection device according to the method. Determining conductance may include use of an impedance detection circuit.
Abstract translation: 开颅手术自动打开的方法包括在计算机处理器的控制下，将颅骨钻入预定距离，并确定何时在钻尖附近有指示颅骨突破的电导滴落。 如果电导率不低于预定阈值，则钻探继续迭代，直到电导低于阈值。 开颅模式可以在处理器的控制下被预先确定并自动钻孔。 可以通过在孔之间内插的路径钻孔来形成颅窗，以形成窗的圆周。 自动开颅开放装置包括具有钻头的钻孔装置，至少一个钻孔装置定位装置，检测装置以及根据该方法控制钻孔装置，定位装置和检测装置的计算机处理器。 确定电导可以包括使用阻抗检测电路。
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