中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

44 records (took 0.028 seconds)

    Methods and apparatus for stimulation of biological tissue
    1.
    发明授权
    Methods and apparatus for stimulation of biological tissue 有权

    公开(公告)号：US10905878B2

    公开(公告)日：2021-02-02

    申请号：US16221582

    申请日：2018-12-17

    Applicant: Massachusetts Institute of Technology

    Inventor： Nir Grossman ,  David Bono ,  Edward Boyden

    IPC: A61N1/36 ,  A61N1/05

    Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

    Methods and Apparatus for Sparse Decomposition Light Field Microscopy
    2.
    发明申请
    Methods and Apparatus for Sparse Decomposition Light Field Microscopy 审中-公开

    公开(公告)号：US20200348502A1

    公开(公告)日：2020-11-05

    申请号：US16694270

    申请日：2019-11-25

    Applicant: Massachusetts Institute of Technology

    Inventor： Young-Gyu Yoon ,  Zeguan Wang ,  Nikita Pak ,  Edward Boyden

    IPC: G02B21/36 ,  G01N21/64 ,  G02B21/06

    Abstract: A light field microscope may record a raw light field video of a sample. The raw video recording may be decomposed into a non-negative low-rank component and a non-negative sparse component. The low-rank component may correspond to a static portion of the sample, and the sparse component may correspond to a dynamically changing portion of the sample. Volume reconstruction may be performed on the sparse component to generate a three-dimensional video of the sample, with improved spatial resolution. In some cases, the decomposition is calculated by an alternating direction method of multipliers algorithm, with the non-negativity of the sparse component and low-rank component enforced after each iteration. In some cases, the volume reconstruction is calculated by Richardson-Lucy iteration with regularization. The sample may be fluorescent. The fluorescence may be indicative of neural activity in the sample.

    Methods and Apparatus for Stimulation of Biological Tissue
    6.
    发明申请
    Methods and Apparatus for Stimulation of Biological Tissue 审中-公开

    公开(公告)号：US20190117975A1

    公开(公告)日：2019-04-25

    申请号：US16221582

    申请日：2018-12-17

    Applicant: Massachusetts Institute of Technology

    Inventor： Nir Grossman ,  David Bono ,  Edward Boyden

    IPC: A61N1/36 ,  A61N1/05

    Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

    Methods and apparatus for neuromodulation
    9.
    发明授权
    Methods and apparatus for neuromodulation 有权

    公开(公告)号：US11166632B2

    公开(公告)日：2021-11-09

    申请号：US16943491

    申请日：2020-07-30

    Applicant: Massachusetts Institute of Technology ,  Elemind Technologies, Inc.

    Inventor： Nir Grossman ,  David Wang ,  Edward Boyden

    IPC: A61B5/00 ,  G06F17/14 ,  A61B5/24 ,  A61B5/369 ,  A61B5/11 ,  A61N5/06 ,  A61N7/00

    Abstract: A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.

Patent Agency Ranking