公开(公告)号：US09757727B2

公开(公告)日：2017-09-12

申请号：US14714452

申请日：2015-05-18

申请人： Massachusetts Institute of Technology

发明人： Scott R. Manalis ,  Robert John Kimmerling ,  Shijie Nigel Chou ,  Vivian C. Hecht

IPC分类号： B01L3/00

CPC分类号： B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/12 ,  B01L2300/163 ,  B01L2400/0487 ,  B01L2400/084

摘要： Hydrodynamic Trap Array. The array includes a serpentine bypassing channel including a plurality of trapping pockets disposed therein, the trapping pockets including a ramp entry portion to decrease flow velocity orthogonal to the trapping pocket to increase trapping efficiency. The relative fluid resistances of the trapping pockets and the serpentine bypassing channel are selected such that a slight majority of the flow is diverted to one of the trapping pockets. A pair of microfluidic bypass channels flank the array of traps allowing independent control of upstream and downstream pressures on each side of the array, thereby decoupling flow magnitude in the bypass channels from flow across the trapping pockets.

公开(公告)号：US20150343444A1

公开(公告)日：2015-12-03

申请号：US14714452

申请日：2015-05-18

申请人： Massachusetts Institute of Technology

发明人： Scott R. Manalis ,  Robert John Kimmerling ,  Shijie Nigel Chou ,  Vivian C. Hecht

IPC分类号： B01L3/00

CPC分类号： B01L3/502761 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2300/12 ,  B01L2300/163 ,  B01L2400/0487 ,  B01L2400/084

摘要： Hydrodynamic Trap Array. the array includes a serpentine bypassing channel including a plurality of trapping pockets disposed therein, the trapping pockets including a ramp entry portion to decrease flow velocity orthogonal to the trapping pocket to increase trapping efficiency. The relative fluid resistances of the trapping pockets and the serpentine bypassing channel are selected such that a slight majority of the flow is diverted to one of the trapping pockets. A pair of microfluidic bypass channels flank the array of traps allowing independent control of upstream and downstream pressures on each side of the array, thereby decoupling flow magnitude in the bypass channels from flow across the trapping pockets.

摘要翻译： 流体动力学陷阱阵列。 阵列包括蛇形旁路通道，其包括设置在其中的多个捕集腔，捕集腔包括斜坡入口部分，以减小与捕获袋正交的流速，以增加捕获效率。 选择捕集袋和蛇形旁路通道的相对流体阻力，使得稍微大部分的流动被转移到捕集袋中的一个。 一对微流体旁路通道位于捕集阱阵列的旁边，允许独立控制阵列每侧的上游和下游压力，从而使旁路通道中的流量大小与穿过捕集阱的流动分离。