公开(公告)号：US20230027746A1

公开(公告)日：2023-01-26

申请号：US17782355

申请日：2020-12-11

Applicant: Massachusetts Institute of Technology

Inventor： Carlo Giovanni Traverso ,  Graham Arrick ,  Torben Sebastian Last

IPC: A61M5/44

Abstract: A device may be configured with a housing having a reservoir and an outlet separated by a heat rupturable membrane. The membrane may serve to separate a material held within the reservoir from the outlet until the membrane is ruptured. The membrane may include a heater configured to selectively rupture the membrane when actuated. The heater may be physically removed and/or thermally insulated from at least one of an environment surrounding the device and the reservoir.

公开(公告)号：US20240017045A1

公开(公告)日：2024-01-18

申请号：US18031269

申请日：2021-10-20

Applicant: Massachusetts Institute of Technology

Inventor： Carlo Giovanni Traverso ,  Niclas Roxhed ,  Siheng You ,  Graham Arrick ,  Torben Sebastian Last

IPC: A61M31/00 ,  A61M39/22 ,  A61M5/172

CPC classification number: A61M31/002 ,  A61M39/22 ,  A61M5/172 ,  A61M2205/33

Abstract: A drug delivery device may be configured to delivery an active pharmaceutical ingredient (API) to a subject via the subject's oral-gastrointestinal (GI) tract. The drug delivery device may be configured to deliver a payload of an API while within the GI tract of the subject. The drug delivery device may include a reservoir, a potential energy source, a plurality of outlets, and a plurality of valves, wherein each outlet has a corresponding valve. The drug delivery device may further include a sensor configured to sense the direction of gravity, and the valves may be selectively opened based on a sensed direction of gravity. Thus, the drug delivery device may dispense a dose of API within the GI tracts of the subject based at least in part on the sensed direction of gravity.

公开(公告)号：US12097021B2

公开(公告)日：2024-09-24

申请号：US17397785

申请日：2021-08-09

Applicant: Massachusetts Institute of Technology ,  Novo Nordisk A/S ,  The Brigham and Women's Hospital, Inc.

Inventor： Graham Arrick ,  Torben Sebastian Last ,  Declan Gwynne ,  Jacob Wainer ,  Carlo Giovanni Traverso ,  Drago Sticker ,  Cody Cleveland ,  Aghiad Ghazal ,  Adam Bohr ,  Jorrit Jeroen Water ,  Brian Mouridsen ,  Jacob Pyung Hwa Jepsen ,  Bozhidar Nikolaev Kozhuharov ,  Kim Frandsen ,  Robert Langer ,  Yi Lu ,  Niclas Roxhed ,  Siheng You

IPC: A61B5/07 ,  A61B5/00

CPC classification number: A61B5/073 ,  A61B5/076 ,  A61B5/4839

Abstract: A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.