公开(公告)号：US20240342099A1

公开(公告)日：2024-10-17

申请号：US18681845

申请日：2022-08-04

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Carlo Giovanni Traverso ,  Declan Gwynne ,  Jacob Wainer ,  Graham Arrick ,  Jesper Windum ,  Kuldeep Sanger ,  Adam Bohr ,  Brian Mouridsen ,  Nikolaj Eusebius Jakobsen ,  Morten Revsgaard Frederiksen ,  Jens Lolle Laursen ,  Ludwig Erik Aguilar

IPC分类号： A61K9/48

CPC分类号： A61K9/4808

摘要： An ingestible device may include one or more deployable limbs configured to orient the ingestible device in a desired orientation. The one or more limbs may be attached to body of the device and wrap around the device in an initial configuration (e.g., prior to deployment of the one or more limbs). The one or more limbs may be configured to deploy when exposed to a predetermined condition. Once the predetermined condition is met, the one or more limbs may extend outwards away from the body such that the one or more deployed limbs serve to orient the ingestible device.

公开(公告)号：US12097021B2

公开(公告)日：2024-09-24

申请号：US17397785

申请日：2021-08-09

申请人： Massachusetts Institute of Technology ,  Novo Nordisk A/S ,  The Brigham and Women's Hospital, Inc.

发明人： Graham Arrick ,  Torben Sebastian Last ,  Declan Gwynne ,  Jacob Wainer ,  Carlo Giovanni Traverso ,  Drago Sticker ,  Cody Cleveland ,  Aghiad Ghazal ,  Adam Bohr ,  Jorrit Jeroen Water ,  Brian Mouridsen ,  Jacob Pyung Hwa Jepsen ,  Bozhidar Nikolaev Kozhuharov ,  Kim Frandsen ,  Robert Langer ,  Yi Lu ,  Niclas Roxhed ,  Siheng You

IPC分类号： A61B5/07 ,  A61B5/00

CPC分类号： A61B5/073 ,  A61B5/076 ,  A61B5/4839

摘要： A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.

公开(公告)号：US20230263956A1

公开(公告)日：2023-08-24

申请号：US18020386

申请日：2021-08-09

申请人： Massachusetts Institute of Technology ,  Novo Nordisk A/S

发明人： Graham Arrick ,  Declan Gwynne ,  Jacob Wainer ,  Carlo Giovanni Traverso ,  Drago Sticker ,  Cody Cleveland ,  Aghiad Ghazal ,  Jorrit Jeroen Water ,  Brian Mouridsen ,  Mette Poulsen ,  Dan Nørtoft Sørensen ,  Jacob Pyung Hwa Jepsen

IPC分类号： A61M5/20 ,  A61M5/30

CPC分类号： A61M5/20 ,  A61M5/30

摘要： A drug delivery device for administration to a subject may include a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device may also include a trigger operatively associated with the potential energy source. The trigger may be configured to actuate at a predetermined location within the subject to deploy a jet of the active pharmaceutical ingredient into a tissue of an adjacent portion of the gastrointestinal tract. In some instances, the jet may be deployed into tissue of the stomach and/or small intestine of the subject. Further, in some embodiments, the operating parameters of the jet may be selected such that the jet penetrates the tissue of the gastrointestinal tract to form a depot of the active pharmaceutical ingredient disposed within the tissue.

公开(公告)号：US20240017045A1

公开(公告)日：2024-01-18

申请号：US18031269

申请日：2021-10-20

申请人： Massachusetts Institute of Technology

发明人： Carlo Giovanni Traverso ,  Niclas Roxhed ,  Siheng You ,  Graham Arrick ,  Torben Sebastian Last

IPC分类号： A61M31/00 ,  A61M39/22 ,  A61M5/172

CPC分类号： A61M31/002 ,  A61M39/22 ,  A61M5/172 ,  A61M2205/33

摘要： A drug delivery device may be configured to delivery an active pharmaceutical ingredient (API) to a subject via the subject's oral-gastrointestinal (GI) tract. The drug delivery device may be configured to deliver a payload of an API while within the GI tract of the subject. The drug delivery device may include a reservoir, a potential energy source, a plurality of outlets, and a plurality of valves, wherein each outlet has a corresponding valve. The drug delivery device may further include a sensor configured to sense the direction of gravity, and the valves may be selectively opened based on a sensed direction of gravity. Thus, the drug delivery device may dispense a dose of API within the GI tracts of the subject based at least in part on the sensed direction of gravity.

公开(公告)号：US20230027746A1

公开(公告)日：2023-01-26

申请号：US17782355

申请日：2020-12-11

申请人： Massachusetts Institute of Technology

发明人： Carlo Giovanni Traverso ,  Graham Arrick ,  Torben Sebastian Last

IPC分类号： A61M5/44

摘要： A device may be configured with a housing having a reservoir and an outlet separated by a heat rupturable membrane. The membrane may serve to separate a material held within the reservoir from the outlet until the membrane is ruptured. The membrane may include a heater configured to selectively rupture the membrane when actuated. The heater may be physically removed and/or thermally insulated from at least one of an environment surrounding the device and the reservoir.