公开(公告)号：US10073087B2

公开(公告)日：2018-09-11

申请号：US14597575

申请日：2015-01-15

Applicant: Massachusetts Institute of Technology

Inventor： Zhengtao Deng ,  Timothy Kuan-Ta Lu

IPC: G01N33/52 ,  A61K49/00

CPC classification number: G01N33/521 ,  A61K49/0093

Abstract: Various aspects and embodiments provided herein are directed to compositions that include at least one nanoparticle linked to a first polypeptide, and a biologically synthesizable polymer linked to at least one second polypeptide that binds covalently to the first polypeptide. Other aspects and embodiments provided herein are directed to methods of producing the foregoing compositions and components therein.

公开(公告)号：US10246637B2

公开(公告)日：2019-04-02

申请号：US15149131

申请日：2016-05-07

Applicant: Massachusetts Institute of Technology

Inventor： Zhengtao Deng ,  Tian Ming ,  He Dong ,  Aishuang Xiang ,  Jing Kong

IPC: H01L51/50 ,  B82Y30/00 ,  C09K11/88 ,  B01J13/02 ,  C09B67/02 ,  B82Y15/00 ,  B82Y40/00

Abstract: A method for preparing a core-shell nanocrystal can include mixing an M-containing precursor solution, an X-containing precursor solution, and an acid or alcohol in an inert atmosphere at a first temperature to form a reaction mixture; maintaining the reaction mixture at the first temperature to grow the MX core of the nanocrystal; raising the temperature of the reaction mixture to a second temperature; and maintaining the reaction mixture at the second temperature to grow a shell of the nanocrystal.

公开(公告)号：US20160326431A1

公开(公告)日：2016-11-10

申请号：US15149131

申请日：2016-05-07

Applicant: Massachusetts Institute of Technology

Inventor： Zhengtao Deng ,  Tan Ming ,  He Dong ,  Aishuang Xiang ,  Jing Kong

IPC: C09K11/88

CPC classification number: C09K11/883 ,  B01J13/02 ,  B82Y15/00 ,  B82Y40/00 ,  C09B67/0097 ,  Y10S977/882

Abstract: A method for preparing a core-shell nanocrystal can include mixing an M-containing precursor solution, an X-containing precursor solution, and an acid or alcohol in an inert atmosphere at a first temperature to form a reaction mixture; maintaining the reaction mixture at the first temperature to grow the MX core of the nanocrystal; raising the temperature of the reaction mixture to a second temperature; and maintaining the reaction mixture at the second temperature to grow a shell of the nanocrystal.

Abstract translation: 制备核 - 壳纳米晶体的方法可以包括在惰性气氛中在第一温度下混合含M前体溶液，含X前体溶液和酸或醇以形成反应混合物; 将反应混合物保持在第一温度以使纳米晶体的MX芯生长; 将反应混合物的温度升至第二温度; 并将反应混合物保持在第二温度以生长纳米晶体的壳。