公开(公告)号：US20210317143A9

公开(公告)日：2021-10-14

申请号：US16825269

申请日：2020-03-20

申请人： Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc.

发明人： Jeremiah A. Johnson ,  Paiman Ghoroghchian ,  Yivan Jiang ,  Hung Vanthanh Nguyen ,  Irene Ghobrial ,  Alexandre Detappe

IPC分类号： C07F5/02 ,  C08L85/04 ,  A61K47/59

摘要： Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.

公开(公告)号：US20200369685A1

公开(公告)日：2020-11-26

申请号：US16825269

申请日：2020-03-20

申请人： Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc.

发明人： Jeremiah A. Johnson ,  Paiman Ghoroghchian ,  Yivan Jiang ,  Hung Vanthanh Nguyen ,  Irene Ghobrial ,  Alexandre Detappe

IPC分类号： C07F5/02 ,  C08L85/04 ,  A61K47/59

摘要： Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.

公开(公告)号：US12042513B2

公开(公告)日：2024-07-23

申请号：US17093832

申请日：2020-11-10

申请人： Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc.

发明人： Jeremiah A. Johnson ,  Hung Vanthanh Nguyen ,  Yivan Jiang ,  Alexandre Detappe ,  Michael Agius ,  Irene Ghobrial ,  XueZhou Wang

IPC分类号： A61K31/795 ,  A61K47/55 ,  A61K47/60 ,  C07D495/14 ,  C08G61/08 ,  C08G65/00

CPC分类号： A61K31/795 ,  A61K47/55 ,  A61K47/60 ,  C07D495/14 ,  C08G61/08 ,  C08G65/00

摘要： Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders.

公开(公告)号：US20210220391A1

公开(公告)日：2021-07-22

申请号：US17093832

申请日：2020-11-10

申请人： Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc.

发明人： Jeremiah A. Johnson ,  Hung Vanthanh Nguyen ,  Yivan Jiang ,  Alexandre Detappe ,  Michael Agius ,  Irene Ghobrial

IPC分类号： A61K31/795 ,  C07D495/14 ,  A61K47/60 ,  A61K47/55 ,  C08G65/00 ,  C08G61/08

摘要： Disclosed multifunctional compounds, conjugates, macromolecules, and polymers that target dysregulated proteins for degradation. Also disclosed are methods of preparation, compositions, kits, and methods of use relating to the degraders.