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    BORONIC ESTER PRODRUGS AND USES THEREOF
    1.
    发明申请
    BORONIC ESTER PRODRUGS AND USES THEREOF 有权

    公开(公告)号：US20210317143A9

    公开(公告)日：2021-10-14

    申请号：US16825269

    申请日：2020-03-20

    申请人： Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc.

    发明人： Jeremiah A. Johnson ,  Paiman Ghoroghchian ,  Yivan Jiang ,  Hung Vanthanh Nguyen ,  Irene Ghobrial ,  Alexandre Detappe

    IPC分类号： C07F5/02 ,  C08L85/04 ,  A61K47/59

    摘要： Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.

    BORONIC ESTER PRODRUGS AND USES THEREOF
    4.
    发明申请
    BORONIC ESTER PRODRUGS AND USES THEREOF 审中-公开

    公开(公告)号：US20200369685A1

    公开(公告)日：2020-11-26

    申请号：US16825269

    申请日：2020-03-20

    申请人： Massachusetts Institute of Technology ,  Dana-Farber Cancer Institute, Inc.

    发明人： Jeremiah A. Johnson ,  Paiman Ghoroghchian ,  Yivan Jiang ,  Hung Vanthanh Nguyen ,  Irene Ghobrial ,  Alexandre Detappe

    IPC分类号： C07F5/02 ,  C08L85/04 ,  A61K47/59

    摘要： Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.

    GENETIC ABNORMALITIES IN PLASMA CELL DYSCRASIAS
    7.
    发明申请
    GENETIC ABNORMALITIES IN PLASMA CELL DYSCRASIAS 有权

    公开(公告)号：US20220064738A1

    公开(公告)日：2022-03-03

    申请号：US17402018

    申请日：2021-08-13

    申请人： Dana-Farber Cancer Institute, Inc.

    发明人： Irene Ghobrial ,  Salomon Manier ,  Yuji Mishima

    IPC分类号： C12Q1/6886 ,  C12Q1/6883 ,  A61P35/02 ,  G01N33/50 ,  G01N33/574

    摘要： Provided herein are non-invasive methods and biomarkers that identify progression and clonal evolution of plasma cell dyscrasias. Also provided are materials and methods for the diagnosis, prognosis, staging, and monitoring of plasma cell dyscrasias based on the presence of the biomarkers in a blood biopsy, as well as methods for monitoring the progression of a plasma cell dyscrasia, determining the efficacy of a therapeutic agent, determining a targeted therapy related to a plasma cell dyscrasia, and/or treating a plasma cell dyscrasia. The methods provided herein provide several advantages over invasive biopsies.