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公开(公告)号：US11351271B2
公开(公告)日：2022-06-07
申请号：US15509258
申请日：2015-09-08
发明人： Ron Weiss , Liliana Wroblewska , Velia Siciliano , Tasuku Kitada , Maria Hottelet Foley , Katie Bodner , Hirohide Saito , Kei Endo , Darrell J. Irvine , Tyler Wagner , Jacob Becraft
摘要： Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
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公开(公告)号：US20220395585A1
公开(公告)日：2022-12-15
申请号：US17735627
申请日：2022-05-03
发明人： Ron Weiss , Liliana Wroblewska , Velia Siciliano , Tasuku Kitada , Maria Hottelet Foley , Katie Bodner , Hirohide Saito , Kei Endo , Darrell J. Irvine , Tyler Wagner , Jacob Becraft
摘要： Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
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公开(公告)号：US11235051B2
公开(公告)日：2022-02-01
申请号：US16634205
申请日：2018-07-27
发明人： Ronald Vogels , Marijn Van Der Neut Kolfschoten , Darrell J. Irvine , Ron Weiss , Ely Blanton Porter , Mariane Bandeira Melo , Tasuku Kitada
IPC分类号： A61K48/00 , A61K9/127 , C07K14/535 , C12N15/85 , A61K31/7115 , A61K39/12 , C12N15/86 , A61K39/00
摘要： Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
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公开(公告)号：US11964007B2
公开(公告)日：2024-04-23
申请号：US17645556
申请日：2021-12-22
发明人： Ronald Vogels , Marijn Van Der Neut Kolfschoten , Darrell J. Irvine , Ron Weiss , Ely Blanton Porter , Mariane Bandeira Melo , Tasuku Kitada
CPC分类号： A61K39/12 , C12N15/86 , A61K2039/53 , A61K2039/545 , C12N2760/18534
摘要： Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
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公开(公告)号：US20220111033A1
公开(公告)日：2022-04-14
申请号：US17645556
申请日：2021-12-22
发明人： Ronald Vogels , Marijn Van Der Neut Kolfschoten , Darrell Irvine , Ron Weiss , Ely Porter , Mariane Bandeira Melo , Tasuku Kitada
摘要： Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
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公开(公告)号：US20180296702A1
公开(公告)日：2018-10-18
申请号：US15509258
申请日：2015-09-08
发明人： Ron Weiss , Liliana Wroblewska , Velia Siciliano , Tasuku Kitada , Maria Hottelet Foley , Katie Bodner , Hirohide Saito , Kei Endo , Darrell J. Irvine , Tyler Wagner , Jacob Becraft
CPC分类号： A61K48/0066 , C12N15/10 , C12N15/63 , C12N15/85 , C12N2840/102
摘要： Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
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公开(公告)号：US11026894B2
公开(公告)日：2021-06-08
申请号：US16739197
申请日：2020-01-10
发明人： Darrell J. Irvine , Ron Weiss , Tasuku Kitada , Mariane Melo , Yuan Zhang
摘要： Disclosed herein are lipid nanoparticles comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000](DSPE-PEG2000), compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
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公开(公告)号：US20200222332A1
公开(公告)日：2020-07-16
申请号：US16739197
申请日：2020-01-10
发明人： Darrell J. Irvine , Ron Weiss , Tasuku Kitada , Mariane Melo , Yuan Zhang
摘要： Disclosed herein are lipid nanoparticles having a specific composition, compositions including such lipid nanoparticles, and methods of treatment using such lipid nanoparticles and compositions.
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