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公开(公告)号：US11351271B2
公开(公告)日：2022-06-07
申请号：US15509258
申请日：2015-09-08
发明人： Ron Weiss , Liliana Wroblewska , Velia Siciliano , Tasuku Kitada , Maria Hottelet Foley , Katie Bodner , Hirohide Saito , Kei Endo , Darrell J. Irvine , Tyler Wagner , Jacob Becraft
摘要： Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
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公开(公告)号：US20220395585A1
公开(公告)日：2022-12-15
申请号：US17735627
申请日：2022-05-03
发明人： Ron Weiss , Liliana Wroblewska , Velia Siciliano , Tasuku Kitada , Maria Hottelet Foley , Katie Bodner , Hirohide Saito , Kei Endo , Darrell J. Irvine , Tyler Wagner , Jacob Becraft
摘要： Engineered synthetic RNA-based genetic circuits are provided that are regulated exclusively at the post-transcriptional level.
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公开(公告)号：US20230414763A1
公开(公告)日：2023-12-28
申请号：US18117752
申请日：2023-03-06
CPC分类号： A61K47/544 , A61K39/12 , A61K39/39 , A61K47/10 , A61P31/18 , A61K2039/543
摘要： What is disclosed is a vaccine comprising an immunogen conjugated to an albumin-binding polymer-lipid tail, wherein the vaccine is suitable for transmucosal (e.g, intranasal) administration. Also disclosed is a method of using the vaccine to immunize a subject by transmucosal (e.g, intranasal) administration of an effective amount of the vaccine, alone or with an adjuvant.
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公开(公告)号：US20230248840A1
公开(公告)日：2023-08-10
申请号：US18302655
申请日：2023-04-18
CPC分类号： A61K47/646 , C07K14/76 , A61P35/00 , C07K7/08 , A61P31/00 , C07K7/06 , A61K39/0011 , C07K14/4748 , A61K39/001192 , C07K2319/00 , A61K38/00
摘要： The present invention provides a conjugate comprising an albumin binding peptide and a cargo, compositions for directing cargos to the lymphatic system, and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease.
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公开(公告)号：US11642416B2
公开(公告)日：2023-05-09
申请号：US17371367
申请日：2021-07-09
IPC分类号： A61K38/00 , A61K47/64 , C07K14/76 , A61P35/00 , C07K7/08 , A61P31/00 , C07K7/06 , A61K39/00 , C07K14/47
CPC分类号： A61K47/646 , A61K39/0011 , A61K39/001192 , A61P31/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K14/76 , A61K38/00 , A61K2039/55561 , A61K2039/6031 , A61K2039/6093 , A61K2039/876 , C07K2319/00
摘要： The present invention provides a conjugate comprising an albumin binding peptide and a cargo, compositions for directing cargos to the lymphatic system, and vaccines. The methods of the invention can be used to increase an immune response, or to treat cancer or an infectious disease.
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公开(公告)号：US11642409B2
公开(公告)日：2023-05-09
申请号：US16857999
申请日：2020-04-24
IPC分类号： A61K39/395 , A61P35/00 , A61K33/08 , A61K38/19 , A61K38/20 , C07K14/52 , C07K14/525 , C07K14/54 , C07K16/28
CPC分类号： A61K39/3955 , A61K33/08 , A61K38/191 , A61K38/195 , A61K38/20 , A61P35/00 , C07K14/521 , C07K14/525 , C07K14/54 , C07K16/2809 , C07K2319/30
摘要： The present disclosure provides immunomodulatory fusion proteins-metal hydroxide complexes comprising an immunomodulatory domain adsorbed to a metal hydroxide via ligand exchange. The disclosure also features compositions and methods of using the same, for example, to treat cancer.
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公开(公告)号：US20230040528A1
公开(公告)日：2023-02-09
申请号：US17816765
申请日：2022-08-02
发明人： Sangeeta N. Bhatia , Darrell J. Irvine , Karl Dane Wittrup , Andrew David Warren , Jaideep S. Dudani , Naveen K. Mehta
摘要： In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of proteases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents).
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公开(公告)号：US11419947B2
公开(公告)日：2022-08-23
申请号：US16175311
申请日：2018-10-30
发明人： Antonio Eric Barberio , Santiago Correa Echavarria , Mariane Bandeira Melo , Talar Tokatlian , Erik Christopher Dreaden , Paula T. Hammond , Darrell J. Irvine
摘要： Disclosed are particles for delivering cytokinese, such as IL-12, for the treatment of cancer. The particles comprise cytokines non-covalently bound to liposomes, where the liposomes are coated with polyelectrolytes.
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公开(公告)号：US10357544B2
公开(公告)日：2019-07-23
申请号：US16195128
申请日：2018-11-19
发明人： Li Tang , Darrell J. Irvine
摘要： The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
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10.发明申请公开(公告)号：US20180311174A1
公开(公告)日：2018-11-01
申请号：US15770442
申请日：2016-10-24
CPC分类号： A61K9/5115 , A61K9/0029 , A61K9/5123 , A61K38/00 , A61K47/6923 , A61K47/6929
摘要： Amphiphilic gold nanoparticles (amph-NPs), composed of gold cores surrounded by an amphiphilic mixed organic ligand shell, are capable of embedding within and traversing lipid membranes. Active agent is bound thereto for use in vaccine and other adjuvant therapies, immunomodulation, and treatment of microbial infections, cancer, autoimmune disease, inflammation and inflammatory disorders.
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