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1.发明公开公开(公告)号：US20230190920A1
公开(公告)日：2023-06-22
申请号：US18047928
申请日：2022-10-19
发明人： Darrell Irvine , Shane Crotty
IPC分类号： A61K39/215
CPC分类号： A61K39/215 , A61K2039/545
摘要： Immunization methods are provided. The methods typically include administering the subject an effective amount of an antigen and adjuvant to induce an immune response against an antigen, the method including two or more of (i) slow prime delivery of antigen and/or adjuvant, a (ii) temporally delayed 2nd immunization, and (iii) a robust adjuvant. Element (i) can be or include temporally extended exposure of antigen, adjuvant, or preferably the combination thereof, such as one or more of repeated administrations, infusion optionally by osmotic pump and escalating dosing. Element (ii) can include administering one or more boost doses of antigen and/or adjuvant, for example between 11 and 35 weeks after the start of the prime administration. A preferred robust adjuvant (iii) is one including non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin.
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2.发明申请公开(公告)号：US20200237903A1
公开(公告)日：2020-07-30
申请号：US16752394
申请日：2020-01-24
发明人： Mark Bathe , Remi Veneziano , Eike-Christian Wamhoff , Tyson Moyer , Benjamin Joseph Read , Darrell Irvine
IPC分类号： A61K39/385 , A61K39/21
摘要： Compositions containing a nucleic acid nanostructure having a desired geometric shape and antigens bound to its surface are provided. The nanostructures can be, for example, in the form of a 6-helix bundle or icosahedron. The nanostructure design allows for control of the relative position and/or stoichiometry of the antigen bound to its surface. The antigens displayed on the nanostructure surface are arranged with the preferred number, spacing, and 3D organization to elicit a robust immune response. The displayed antigen can be an HIV immunogen such as eOD-GT6, eOD-GT8, or variants thereof. The compositions may thus be useful as immunogens, vaccines, immunostimulators, adjuvants, and the like. Methods of inducing immune responses, inducing protective immunity, inducing the production of neutralizing antibodies or inhibitory antibodies, inducing tolerance, and treating cancer, infectious or autoimmune diseases are also provided.
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公开(公告)号：US20190015522A1
公开(公告)日：2019-01-17
申请号：US16040181
申请日：2018-07-19
发明人： Darrell Irvine , Haipeng Liu
摘要： Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.
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公开(公告)号：US20230330219A1
公开(公告)日：2023-10-19
申请号：US17819204
申请日：2022-08-11
发明人： Mark Bathe , Remi Veneziano , Eike-Christian Wamhoff , Tyson Moyer , Benjamin Joseph Read , Rebecca Du , Darrell Irvine
IPC分类号： A61K39/385 , A61K39/21
CPC分类号： A61K39/385 , A61K39/21 , A61K2039/55588
摘要： Compositions containing a nucleic acid nanostructure having a desired geometric shape and immunostimulatory agent(s) bound to its surface are provided. The nanostructures can be, for example, in the form of a 6-helix bundle, or icosahedron, or a pentagonal bipyramid. The nanostructure design allows for control of the relative position and/or stoichiometry of the immunostimulatory agent(s) bound to its surface. The immunostimulatory agent(s) displayed on the nanostructure surface are arranged with the preferred number, spacing, and 3D organization to elicit a robust immune response. The displayed antigen can be a TLR agonist, such as a TLR9 agonist. The immunostimulatory compositions may thus be useful as immunogens, vaccines, adjuvants, and the like. Methods of inducing immune responses, and for targeted induction of TLR activation are also provided.
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公开(公告)号：US11419932B2
公开(公告)日：2022-08-23
申请号：US16752394
申请日：2020-01-24
发明人： Mark Bathe , Remi Veneziano , Eike-Christian Wamhoff , Tyson Moyer , Benjamin Joseph Read , Darrell Irvine
摘要： Compositions containing a nucleic acid nanostructure having a desired geometric shape and antigens bound to its surface are provided. The nanostructures can be, for example, in the form of a 6-helix bundle or icosahedron. The nanostructure design allows for control of the relative position and/or stoichiometry of the antigen bound to its surface. The antigens displayed on the nanostructure surface are arranged with the preferred number, spacing, and 3D organization to elicit a robust immune response. The displayed antigen can be an HIV immunogen such as eOD-GT6, eOD-GT8, or variants thereof. The compositions may thus be useful as immunogens, vaccines, immunostimulators, adjuvants, and the like. Methods of inducing immune responses, inducing protective immunity, inducing the production of neutralizing antibodies or inhibitory antibodies, inducing tolerance, and treating cancer, infectious or autoimmune diseases are also provided.
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公开(公告)号：US20160095936A1
公开(公告)日：2016-04-07
申请号：US14790432
申请日：2015-07-02
发明人： Darrell Irvine , Haipeng Liu
CPC分类号： A61K47/645 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K47/542 , A61K47/543 , A61K47/643 , A61K47/6455
摘要： Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.
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公开(公告)号：US09107904B2
公开(公告)日：2015-08-18
申请号：US13844075
申请日：2013-03-15
发明人： Darrell Irvine , Haipeng Liu
CPC分类号： A61K47/645 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K47/542 , A61K47/543 , A61K47/643 , A61K47/6455
摘要： Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.
摘要翻译： 公开了用于增强货物运送到淋巴结的脂质缀合物。 脂质缀合物通常包括三个结构域：结合白蛋白的亲油结构域，极性嵌段结构域和货物如分子佐剂或免疫刺激化合物（例如寡核苷酸）或抗原肽。 根据货物，极地块的长度和组成可以调整为将平衡推向白蛋白结合，稳定的胶束形成或细胞插入。 缀合物可以施用于受试者，例如具有癌症或感染的受试者，以诱导或增强受试者中的强壮的免疫应答。
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公开(公告)号：US20220111033A1
公开(公告)日：2022-04-14
申请号：US17645556
申请日：2021-12-22
发明人： Ronald Vogels , Marijn Van Der Neut Kolfschoten , Darrell Irvine , Ron Weiss , Ely Porter , Mariane Bandeira Melo , Tasuku Kitada
摘要： Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
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公开(公告)号：US20210187112A1
公开(公告)日：2021-06-24
申请号：US17193999
申请日：2021-03-05
发明人： Darrell Irvine , Haipeng Liu
摘要： Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.
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公开(公告)号：US10953105B2
公开(公告)日：2021-03-23
申请号：US16040181
申请日：2018-07-19
发明人： Darrell Irvine , Haipeng Liu
摘要： Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. Depending on the cargo, the length and compositions of the polar block can be tailored to push the equilibrium toward albumin binding, stable micelle formation, or cell insertion. The conjugates can be administered to a subject, for example, a subject with cancer or an infection, to induce or enhance a robust immune response in the subject.
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