公开(公告)号：US20170360850A1

公开(公告)日：2017-12-21

申请号：US15535831

申请日：2015-12-22

Applicant: Massachusetts Institute of Technology ,  Synlogic, Inc.

Inventor： Timothy Kuan-Ta Lu ,  Jacob Rosenblum Rubens ,  Isaak Elis Mueller ,  Gianluca Selvaggio ,  Paul Miller ,  Dean Falb ,  Vincent Isabella ,  Jonathan Kotula

IPC: A61K35/741 ,  C07K16/24 ,  C07K14/54 ,  A61K39/395 ,  A61K38/20 ,  A61K36/064 ,  A61K31/122 ,  C12N15/70 ,  A61K9/00

CPC classification number: A61K35/741 ,  A61K9/0053 ,  A61K31/122 ,  A61K35/74 ,  A61K36/064 ,  A61K38/19 ,  A61K38/204 ,  A61K38/2066 ,  A61K39/3955 ,  C07K14/5428 ,  C07K16/241 ,  C12N15/63 ,  C12N15/70 ,  G01N33/573 ,  G01N33/6863

Abstract: Aspects of the present disclosure relate to genetically engineered organisms useful for the diagnosis and treatment of inflammatory bowel disease.

公开(公告)号：US20180325963A1

公开(公告)日：2018-11-15

申请号：US15755836

申请日：2016-08-31

Applicant: Synlogic, Inc.

Inventor： Vincent Isabella ,  Dean Falb ,  Cami Leigh Anderson ,  Paul Miller ,  Yves Millet ,  Jonathan Kotula

IPC: A61K35/74 ,  C12N15/70 ,  C12N15/52 ,  A61P3/00

CPC classification number: A61K35/74 ,  A61P3/00 ,  C07K14/195 ,  C12N1/00 ,  C12N15/52 ,  C12N15/70 ,  Y02A50/473

Abstract: The present invention provides recombinant bacterial cells comprising at least one heterologous gene encoding at least one oxalate catabolism enzyme. In another aspect, the recombinant bacterial cells further comprise at least one heterologous gene encoding an importer of oxalate. The invention further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders in which oxalate is detrimental, such as hyperoxaluria, using the pharmaceutical compositions of the invention.