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    Method for producing template-textured materials with high binding specificity and selectivity and utilization of said materials
    1.
    发明授权
    Method for producing template-textured materials with high binding specificity and selectivity and utilization of said materials 失效
    用于生产具有高结合特异性和所述材料的选择性和利用率的模板织构材料的方法

    公开(公告)号：US06753396B2

    公开(公告)日：2004-06-22

    申请号：US10148819

    申请日：2002-09-03

    申请人： Mathias Ulbricht ,  Tatinna Sergeyeva ,  Heike Matuschewski ,  Uwe Schedler ,  Sergey A. Piletsky

    发明人： Mathias Ulbricht ,  Tatinna Sergeyeva ,  Heike Matuschewski ,  Uwe Schedler ,  Sergey A. Piletsky

    IPC分类号： C08F22046

    CPC分类号： G01N30/482 ,  B01J20/268 ,  B01J20/281 ,  B01J20/3057 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3276 ,  B01J20/3278 ,  B01J20/3282 ,  B01J20/3285 ,  B01J2220/54

    摘要： The invention relates to a method for the production of a template-textured material by synthesis of a template-textured polymer (TTP) by performing crosslinking polymerization of functional monomers on a support in the presence of a template, which method is characterized in that a support having a thin polymer layer on the surface thereof is added with a reaction mixture consisting of polymerization initiator, template, functional monomer, crosslinker, solvent and/or buffer and, following sorption of the reaction mixture in the thin polymer layer, the polymerization is initiated and continued until the absorption capacity of the thin polymer layer for the template-textured polymer (TTP) is reached, and the template is optionally removed in a final step, the support used being selected in such a way that it cannot absorb the reaction solution. The materials of the invention are remarkable for their high binding specificity and selectivity for the template.

    摘要翻译： 本发明涉及一种通过在模板存在下通过在载体上进行官能单体的交联聚合来通过合成模板织构化聚合物（TTP）来生产模板织构材料的方法，该方法的特征在于， 在其表面上具有薄聚合物层的载体中加入由聚合引发剂，模板，官能单体，交联剂，溶剂和/或缓冲剂组成的反应混合物，并且在聚合物层中吸附反应混合物后，聚合反应 引发并持续直到达到模板 - 织构聚合物（TTP）的薄聚合物层的吸收能力，并且在最终步骤中任选地除去模板，使用的载体以不能吸收反应的方式进行选择 解。 本发明的材料对于模板的高结合特异性和选择性是显着的。

    RATIONALLY DESIGNED SELECTIVE BINDING POLYMERS
    2.
    发明申请
    RATIONALLY DESIGNED SELECTIVE BINDING POLYMERS 审中-公开
    方案设计选择性结合聚合物

    公开(公告)号：US20100009859A1

    公开(公告)日：2010-01-14

    申请号：US11722023

    申请日：2005-12-21

    申请人： Sergey A. Piletsky ,  Olena Piletska ,  Khalku Karim ,  Coulton H. Legge ,  Sreenath Subrahmanyam

    发明人： Sergey A. Piletsky ,  Olena Piletska ,  Khalku Karim ,  Coulton H. Legge ,  Sreenath Subrahmanyam

    IPC分类号： C40B30/02

    CPC分类号： C08F2/00 ,  C08F2400/02

    摘要： A polymer able to bind a target compound selectively is designed by producing a virtual library of polymerisable monomers, and molecular models of the target compound and one or more potential interferents. The library is screened to identify monomers with substantial differences in strengths of binding to (a) target and (b) interferent. Monomers favouring the target may be used to produce polymers for selectively binding the target, for use in separation or analytical processes.

    摘要翻译： 通过产生可聚合单体的虚拟文库，目标化合物的分子模型和一种或多种潜在的干扰物，可以设计能够选择性地结合靶化合物的聚合物。 筛选文库以鉴定与（a）靶和（b）干扰物结合强度有显着差异的单体。 有利于靶的单体可用于制备用于选择性结合靶的聚合物，用于分离或分析过程。