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公开(公告)号：US08192451B2
公开(公告)日：2012-06-05
申请号：US12466164
申请日：2009-05-14
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/22012 , A61B17/320725 , A61B17/32075 , A61B2017/003 , A61B2017/22014 , A61B2017/22038
摘要： The invention provides a rotational and/or axially translatable atherectomy system, device and method having a flexible, elongated drive shaft or catheter having an expandable and collapsible conical coil with a cutting edge on the coil's large diameter proximal end. When retracted, the coil's sections are collapsed around each other, held together in the retracted position by a sheath that, when distally retracted, allows the coil to automatically expand. The coil is expanded at a point distal to the occlusion, then pulled proximally to cut the occluding material near the lumen wall. The proximal pulling force may be combined with low-speed rotation and/or translation and/or axial vibration at low to ultrasonic frequency.
摘要翻译： 本发明提供一种旋转和/或可轴向平移的粥样斑块切除系统，装置和方法，其具有柔性细长的驱动轴或导管，其具有在线圈的大直径近端具有切割边缘的可膨胀和可折叠的圆锥形线圈。 当缩回时，线圈的部分彼此折叠，通过护套在缩回位置处一起保持在一起，当护套在远端缩回时允许线圈自动膨胀。 线圈在远离闭塞的位置膨胀，然后向近侧拉动以切割管腔壁附近的闭塞材料。 近侧拉力可以在低至超声频率下与低速旋转和/或平移和/或轴向振动相结合。
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公开(公告)号：US20090306691A1
公开(公告)日：2009-12-10
申请号：US12466164
申请日：2009-05-14
CPC分类号： A61B17/320758 , A61B17/22012 , A61B17/320725 , A61B17/32075 , A61B2017/003 , A61B2017/22014 , A61B2017/22038
摘要： The invention provides a rotational and/or axially translatable atherectomy system, device and method comprising a flexible, elongated drive shaft or catheter comprising an expandable and collapsible conical coil with a cutting edge on the coil's large diameter proximal end. When retracted, the coil's sections are collapsed around each other, held together in the retracted position by a sheath that, when distally retracted, allows the coil to automatically expand. The coil is expanded at a point distal to the occlusion, then pulled proximally to cut the occluding material near the lumen wall. The proximal pulling force may be combined with low-speed rotation and/or translation and/or axial vibration at low to ultrasonic frequency.
摘要翻译： 本发明提供了一种旋转和/或轴向可平移的粥样斑块切除系统，装置和方法，其包括柔性细长的驱动轴或导管，其包括在线圈的大直径近端上具有切割边缘的可膨胀和可折叠的锥形线圈。 当缩回时，线圈的部分彼此折叠，通过护套在缩回位置处一起保持在一起，当护套在远端缩回时允许线圈自动膨胀。 线圈在远离闭塞的位置膨胀，然后向近侧拉动以切割管腔壁附近的闭塞材料。 近侧拉力可以在低至超声频率下与低速旋转和/或平移和/或轴向振动相结合。
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3.发明申请DIRECTIONAL ROTATIONAL ATHERECTOMY DEVICE WITH OFFSET SPINNING ABRASIVE ELEMENT 有权带偏心旋转抛光元件的方向旋转自动装置公开(公告)号：US20100121361A1
公开(公告)日：2010-05-13
申请号：US12465807
申请日：2009-05-14
申请人： Charles A. Plowe , Jesse C. Darley , David C. Franchino , Matthew D. Cambronne , Jody Rivers , Cassandra A. Piippo , Robert E. Kohler
发明人： Charles A. Plowe , Jesse C. Darley , David C. Franchino , Matthew D. Cambronne , Jody Rivers , Cassandra A. Piippo , Robert E. Kohler
CPC分类号： A61B17/320758 , A61B2017/320004 , A61B2017/320766 , Y10T29/49863
摘要： The invention provides a rotational atherectomy system, device and method comprising a flexible, elongated, rotatable drive shaft with a pre-curved abrasive section disposed within a catheter that deforms the abrasive section to a substantially straight profile and, when the abrasive section is moved distally out of the catheter, the abrasive section resumes its pre-curved profile. Directional ablation is achieved by rotation of the drive shaft along its pre-curved axis as the abrasive section is urged against a portion of the lumen wall.
摘要翻译： 本发明提供一种旋转粥样斑块切除系统，装置和方法，其包括柔性的，细长的可旋转的驱动轴，其具有设置在导管内的预弯曲磨料部分，其将研磨部分变形为基本上直的轮廓，并且当研磨部分向远侧移动时 在导管之外，研磨部分恢复其预弯曲轮廓。 当研磨部分被推压到腔壁的一部分时，通过驱动轴沿其预弯曲轴线的旋转来实现定向消融。
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4.发明授权Directional rotational atherectomy device with offset spinning abrasive element 有权带偏心旋转研磨元件的定向旋转粥样斑块切除装置公开(公告)号：US09101387B2
公开(公告)日：2015-08-11
申请号：US12465807
申请日：2009-05-14
申请人： Charles A. Plowe , Jesse C. Darley , David C. Franchino , Matthew D. Cambronne , Jody Rivers , Cassandra A. Piippo , Robert E. Kohler
发明人： Charles A. Plowe , Jesse C. Darley , David C. Franchino , Matthew D. Cambronne , Jody Rivers , Cassandra A. Piippo , Robert E. Kohler
IPC分类号： A61B17/22 , A61B17/3207 , A61B17/32
CPC分类号： A61B17/320758 , A61B2017/320004 , A61B2017/320766 , Y10T29/49863
摘要： The invention provides a rotational atherectomy system, device and method comprising a flexible, elongated, rotatable drive shaft with a pre-curved abrasive section disposed within a catheter that deforms the abrasive section to a substantially straight profile and, when the abrasive section is moved distally out of the catheter, the abrasive section resumes its pre-curved profile. Directional ablation is achieved by rotation of the drive shaft along its pre-curved axis as the abrasive section is urged against a portion of the lumen wall.
摘要翻译： 本发明提供一种旋转粥样斑块切除系统，装置和方法，其包括柔性的，细长的可旋转的驱动轴，其具有设置在导管内的预弯曲磨料部分，其将研磨部分变形为基本上直的轮廓，并且当研磨部分向远侧移动时 在导管之外，研磨部分恢复其预弯曲轮廓。 当研磨部分被推压到腔壁的一部分时，通过驱动轴沿其预弯曲轴线的旋转来实现定向消融。
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公开(公告)号：US09205026B2
公开(公告)日：2015-12-08
申请号：US13827884
申请日：2013-03-14
IPC分类号： A61B19/00 , A61J1/20 , A61J1/14 , B65D51/00 , B65D75/58 , B65D81/32 , B65B3/00 , A61J1/10 , A61M39/00
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A medicament container having an opening that provides access to a cavity defined by the medicament container. A stopper is sealingly positioned within the opening of the medicament container and configured to be forced into the cavity to open the medicament container. The medicament container also includes a mating member configured to mate with a complementary receiver associated with a second container to connect the medicament container to a second container. The medicament container further includes a radial seal configured to engage and seal against an interior seal wall associated with a second container prior to the stopper being forced into the cavity defined by the medicament container. A system is also provided for establishing fluid communication between a first container and a second container. The system includes a first container (e.g., a medicament container) having a radial seal, a second container, and a port assembly.
摘要翻译： 一种具有开口的药物容器，该开口提供对由药物容器限定的空腔的通路。 塞子被密封地定位在药物容器的开口内并构造成被迫进入空腔以打开药物容器。 药物容器还包括配合构件，其配置成与与第二容器相关联的补充接收器配合，以将药物容器连接到第二容器。 药物容器还包括径向密封件，其构造成在止动器被迫进入由药物容器限定的空腔之前与第二容器相关联的内部密封壁接合并密封。 还提供了一种用于建立第一容器和第二容器之间的流体连通的系统。 该系统包括具有径向密封件，第二容器和端口组件的第一容器（例如，药物容器）。
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6.发明授权公开(公告)号：US08162964B2
公开(公告)日：2012-04-24
申请号：US12466179
申请日：2009-05-14
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/320725 , A61B2017/00867 , A61B2017/320733
摘要： The invention provides a rotational atherectomy system, device and method having a flexible, elongated, rotatable catheter tube that is split into two elements, a biasing element and a cutting element, distally and wherein the biasing element and cutting element are capable of forming a first and retracted position for insertion into a lumen and a second and expanded position for ablation. The biasing element is biased in the expanded position, thereby placing a biasing force against the lumen wall and pressing the cutting element against the opposite side of the lumen wall for directional cutting and/or grinding, either by rotation, axial translation, vibration or a combination thereof.
摘要翻译： 本发明提供了一种旋转粥样斑块切除系统，装置和方法，其具有柔性的，细长的，可旋转的导管管，其被向远侧分成两个元件，偏置元件和切割元件，并且其中偏置元件和切割元件能够形成第一 以及用于插入管腔的缩回位置和用于消融的第二和扩展位置。 偏置元件在扩展位置偏置，从而向内腔壁施加偏压力，并将切割元件压靠在管腔壁的相对侧上，以便通过旋转，轴向平移，振动或 的组合。
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公开(公告)号：US20140005629A1
公开(公告)日：2014-01-02
申请号：US13537349
申请日：2012-06-29
IPC分类号： A61J1/20
CPC分类号： A61J1/2089 , A61J1/10 , A61J1/2041 , A61J1/2075
摘要： A system for mixing the contents of a first container with the contents of a second container. The second container has a port assembly for receiving the first container. The port assembly has an actuator that is constructed to access the cavity of the first container during activation of the system and to allow fluid communication between the first container and the second container. The port assembly further includes a movable plug that provides a seal for the second container. The plug is configured to move axially relative to the actuator during activation of the system, thereby opening the seal of the second container and providing fluid communication between the first container and the second container.
摘要翻译： 一种用于将第一容器的内容物与第二容器的内容物混合的系统。 第二容器具有用于接收第一容器的端口组件。 端口组件具有构造成在系统启动期间接近第一容器的空腔并且允许第一容器和第二容器之间的流体连通的致动器。 端口组件还包括为第二容器提供密封的可移动塞。 塞子被构造成在系统启动期间相对于致动器轴向移动，从而打开第二容器的密封并提供第一容器和第二容器之间的流体连通。
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公开(公告)号：US08408122B2
公开(公告)日：2013-04-02
申请号：US12396928
申请日：2009-03-03
IPC分类号： B41F17/00
CPC分类号： B41F17/001
摘要： An auto alignment pad printer for transferring print to an associated object includes a frame, a fixture for supporting the associated object and a cliché operably mounted to the frame. The cliché includes at least one etched region and is adapted to receive ink in the etched region. An ink cup is configured to deposit ink into the etched region. A pad applicator includes a pad support having at least one pad thereon. The pad is adapted to move into and out of contact with the etched region to receive ink from the etched region and to contact an object to transfer the received ink to the object. A pad applicator alignment assembly includes a first set of cooperating projections and receivers mounted to the pad applicator and to the cliché and/or the frame near to the cliché, and a second set of cooperating projections and receivers mounted to the pad applicator and to the fixture for supporting the object. The first set of cooperating projections and receivers are configured to position the pad for precise movement into contact with the cliché to receive ink from the cliché. The second set of cooperating projections and receivers are configured to position the pad for precise movement into contact with the object to transfer the received ink to the associated object.
摘要翻译： 用于将打印件转印到相关对象的自动对准打印机打印机包括框架，用于支撑相关联对象的固定装置和可操作地安装到框架上的陈词滥调。 陈设包括至少一个蚀刻区域，并且适于在蚀刻区域中接收墨水。 油墨杯配置成将油墨沉积到蚀刻区域中。 衬垫施加器包括其上具有至少一个垫的衬垫支撑件。 衬垫适于移动进入和离开与蚀刻区域的接触以从蚀刻区域接收墨水并接触物体以将接收的墨水转移到物体。 垫敷贴器对准组件包括第一组配合的突起和接收器，其安装到衬垫施用器和靠近底板的桌面和/或框架，以及第二组协作的突出和接收器，安装到衬垫施用器 夹具用于支撑物体。 第一组配合的投影和接收器被配置成定位垫以精确地移动与陈词滥调接触，以从陈词滥调中接收墨。 第二组配合的投影和接收器被配置成定位垫以精确地移动与物体接触，以将接收到的墨转移到相关联的物体。
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公开(公告)号：US08241265B2
公开(公告)日：2012-08-14
申请号：US12184005
申请日：2008-07-31
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.
摘要翻译： 用于将包含在第一容器中的药物与包含在第二容器中的稀释剂或流体混合或重构的系统。 第二容器具有用于接合第一容器的端口对接组件。 第一容器在端口对接组件内可旋转并可轴向滑动。 端口对接组件具有致动器以促使止动器将第一容器流体地密封到第一容器的内部。 端口对接组件还包括可移动插塞，其构造成将第二容器流体地密封在第一对接位置中并且在第二致动位置中提供对第二容器内部的通路，由此第一和第二容器之间的流体连通是 当第一和第二容器处于第二激活位置时。
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10.发明申请ATHERECTOMY DEVICE, SYSTEM AND METHOD HAVING A BI-DIRECTIONAL DISTAL EXPANDABLE ABLATION ELEMENT 有权具有双向可伸缩消除元素的自适应装置，系统和方法公开(公告)号：US20110144671A1
公开(公告)日：2011-06-16
申请号：US12817354
申请日：2010-06-17
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B17/32075 , A61B2017/320028 , A61B2017/320775
摘要： The invention provides a rotational atherectomy system, device and method comprising a bi-directional drive shaft with a flexible ablation element disposed at the distal end of the drive shaft. The flexible ablation element comprises a first retracted position for insertion into vasculature and a second expanded position for ablation, i.e., cutting, sanding and/or grinding. The ablation element comprises more than one flexible finger or blade which allows changing, in certain embodiments, of curvature radius to fit inside a deployment catheter and/or enlarge to the diameter of larger lumens, up to at least 9 mm in diameter. Bi-directional rotation of the expanded ablation element allows cutting in one rotational direction and grinding and/or sanding in the opposite rotational direction.
摘要翻译： 本发明提供了一种旋转粥样斑块切除系统，装置和方法，其包括双向驱动轴，其具有设置在驱动轴的远端处的柔性消融元件。 柔性消融元件包括用于插入脉管系统的第一缩回位置和用于消融的第二扩展位置，即切割，打磨和/或研磨。 消融元件包括多于一个的柔性指状物或刀片，其允许在某些实施例中改变曲率半径以配合在展开导管内部和/或扩大到直径至少为9mm的较大腔的直径。 扩展的消融元件的双向旋转允许沿一个旋转方向进行切割，并在相反的旋转方向进行研磨和/或打磨。
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