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公开(公告)号：US20090162382A1
公开(公告)日：2009-06-25
申请号：US12016884
申请日：2008-01-18
IPC分类号： A61K39/395 , C07K16/44 , C07H21/04 , A61P35/00
CPC分类号： C07K16/30 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732
摘要： The present invention describes antibodies that target CA9, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
摘要翻译： 本发明描述了靶向CA9的抗体，其中所述抗体相对于亲本抗体包含至少一个修饰，其中与亲本抗体相比，该修饰改变对FcγRR的亲和力或改变效应子功能。 还公开了使用本发明的抗体的方法。
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2.发明授权Anti-CD40 antibodies and methods of inhibiting proliferation of CD40 expressing cells 有权抗CD40抗体和抑制CD40表达细胞增殖的方法公开(公告)号：US08551485B2
公开(公告)日：2013-10-08
申请号：US12864075
申请日：2009-01-21
申请人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , Eugene Alexander Zhukovsky
发明人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , Eugene Alexander Zhukovsky
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72
摘要： The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
摘要翻译： 本发明描述了针对CD40的人源化抗体，其中所述抗体相对于亲本抗体包含至少一个修饰，其中与亲本抗体相比，该修饰改变对FcγRR的亲和力或改变效应子功能。 还公开了使用本发明的抗体的方法。
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公开(公告)号：US20110027276A1
公开(公告)日：2011-02-03
申请号：US12864075
申请日：2009-01-21
申请人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik Weiking Pong , Eugene Alexande Zhukovsky
发明人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik Weiking Pong , Eugene Alexande Zhukovsky
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72
摘要： The present invention describes humanized antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
摘要翻译： 本发明描述了针对CD40的人源化抗体，其中所述抗体相对于亲本抗体包含至少一个修饰，其中与亲本抗体相比，该修饰改变对FcγR的亲和力或改变效应子功能。 还公开了使用本发明的抗体的方法。
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公开(公告)号：US20080199471A1
公开(公告)日：2008-08-21
申请号：US12018754
申请日：2008-01-23
申请人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , Eugene Alexander Zhukovsky
发明人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , Eugene Alexander Zhukovsky
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , A61P43/00 , C07H21/00
CPC分类号： C07K16/2878 , C07K2317/24 , C07K2317/72 , C07K2317/73 , C07K2317/732
摘要： The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
摘要翻译： 本发明描述了靶向CD40的抗体，其中所述抗体相对于亲本抗体包含至少一个修饰，其中与亲本抗体相比，该修饰改变对FcγRR的亲和力或改变效应子功能。 还公开了使用本发明的抗体的方法。
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公开(公告)号：US20120082664A1
公开(公告)日：2012-04-05
申请号：US13221811
申请日：2011-08-30
申请人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , John O. Richards , Eugene Alexander Zhukovsky
发明人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , John O. Richards , Eugene Alexander Zhukovsky
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/28 , C12N15/13
CPC分类号： C07K16/2896 , C07K16/2803 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
摘要翻译： 本发明描述了靶向CD19的抗体，其中所述抗体相对于亲本抗体包含至少一个修饰，其中与亲本抗体相比，该修饰改变对FcγR的亲和力或改变效应子功能。 还公开了使用本发明的抗体的方法。
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公开(公告)号：US20080219974A1
公开(公告)日：2008-09-11
申请号：US11857310
申请日：2007-09-18
申请人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
发明人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
IPC分类号： A61K39/395 , C07K16/18 , A61P37/00 , C07H21/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/72 , C07K2317/732 , C07K2317/92
摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
摘要翻译： 本公开描述了靶向HM1.24的抗体。 在各个方面，抗体具有特异性CDR，可变或全长序列，与亲本抗体具有修饰，或者相对于亲本抗体，相对于母体抗体，包括改变对FcγRR的亲和力或改变效应子功能的亲本抗体的至少一个修饰 抗体。 还公开了编码抗体的核酸和使用抗体的方法。
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公开(公告)号：US08524867B2
公开(公告)日：2013-09-03
申请号：US12377251
申请日：2007-08-14
申请人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , John O. Richards , Eugene Alexander Zhukovsky
发明人： Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik WeiKing Pong , John O. Richards , Eugene Alexander Zhukovsky
CPC分类号： C07K16/2896 , C07K16/2803 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.
摘要翻译： 靶向CD19的抗体，其中所述抗体相对于亲本抗体包含至少一个修饰，其中与亲本抗体相比，所述修饰改变对FcγR的亲和力或改变效应子功能，以及使用抗体的方法。
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公开(公告)号：US20100104557A1
公开(公告)日：2010-04-29
申请号：US12441885
申请日：2007-09-18
申请人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
发明人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
IPC分类号： A61K39/395 , C07K16/18 , A61P37/06
CPC分类号： C07K16/2896 , A61K31/454 , A61K31/573 , A61K31/69 , A61K39/3955 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
摘要翻译： 本公开描述了靶向HM1.24的抗体。 在各个方面，抗体具有特异性CDR，可变或全长序列，与亲本抗体具有修饰，或者相对于亲本抗体，包括改变对FcγR的亲和力或改变效应子功能的亲本抗体的至少一个修饰， 亲本抗体。 还公开了编码抗体的核酸和使用抗体的方法。
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公开(公告)号：US09040042B2
公开(公告)日：2015-05-26
申请号：US13794676
申请日：2013-03-11
申请人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
发明人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
IPC分类号： A61K39/395 , C07K16/28 , A61K31/454 , A61K31/573 , A61K31/69
CPC分类号： C07K16/2896 , A61K31/454 , A61K31/573 , A61K31/69 , A61K39/3955 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
摘要翻译： 本公开描述了靶向HM1.24的抗体。 在各个方面，抗体具有特异性CDR，可变或全长序列，与亲本抗体具有修饰，或者相对于亲本抗体，相对于母体抗体，包括改变对FcγR的亲和力或改变效应子功能的亲本抗体的至少一个修饰 抗体。 还公开了编码抗体的核酸和使用抗体的方法。
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公开(公告)号：US08394374B2
公开(公告)日：2013-03-12
申请号：US12441885
申请日：2007-09-18
申请人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
发明人： Matthew J. Bernett , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Umesh S. Muchhal , Duc-Hanh Thi Nguyen , John O. Richards
IPC分类号： A61K39/395
CPC分类号： C07K16/2896 , A61K31/454 , A61K31/573 , A61K31/69 , A61K39/3955 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/92
摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
摘要翻译： 本公开描述了靶向HM1.24的抗体。 在各个方面，抗体具有特异性CDR，可变或全长序列，与亲本抗体具有修饰，或者相对于亲本抗体，包括改变对FcγR的亲和力或改变效应子功能的亲本抗体的至少一个修饰， 亲本抗体。 还公开了编码抗体的核酸和使用抗体的方法。
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