公开(公告)号：US07994294B2

公开(公告)日：2011-08-09

申请号：US11603491

申请日：2006-11-22

申请人： Matthew J. Hart

发明人： Matthew J. Hart

IPC分类号： C07K16/00 ,  C07K16/26

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12Q1/6876

摘要： The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates the activity of a Rho GTPase, is described. However, the present invention relates to other GEFs, especially other Rho-GEFs. The present invention particularly relates to an isolated p115 Rho-GEF polypeptide or fragments of it, a nucleic acid coding for p115 Rho-GEF or fragments of it, and derivatives of the polypeptide and nucleic acid. The invention also relates to methods of using such polypeptides, nucleic acids, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. Another aspect of the present invention involves antibodies and other ligands which recognize p115 Rho-GEF, regulators of p115 Rho-GEF activity, and methods of treating pathological conditions associated or related to a Rho GTPase.

摘要翻译： 本发明涉及鸟嘌呤交换因子（GEF），例如Rho-GEF，例如p15Rho-GEF的所有方面。 通过调节GTP酶的活性，GEF在体外和体内调节细胞信号通路。 作为说明，描述了调节Rho GTP酶的活性的p115Rho-GEF。 然而，本发明涉及其他GEF，特别是其他Rho-GEF。 本发明特别涉及分离的p115Rho-GEF多肽或其片段，编码p115Rho-GEF或其片段的核酸，以及多肽和核酸的衍生物。 本发明还涉及使用此类多肽，核酸或其衍生物的方法，例如在治疗学，诊断学和研究工具中。 本发明的另一方面涉及识别p115Rho-GEF，p115Rho-GEF活性的调节剂以及治疗与Rho GTP酶相关或相关的病理学病症的方法的抗体和其它配体。

公开(公告)号：US06569655B2

公开(公告)日：2003-05-27

申请号：US09865960

申请日：2001-05-25

申请人： Matthew J. Hart

发明人： Matthew J. Hart

IPC分类号： C12N900

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12Q1/6876

摘要： The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates the activity of a Rho GTPase, is described. However, the present invention relates to other GEFs, especially other Rho-GEFs. The present invention particularly relates to an isolated p115 Rho-GEF polypeptide or fragments of it, a nucleic acid coding for p115 Rho-GEF or fragments of it, and derivatives of the polypeptide and nucleic acid. The invention also relates to methods of using such polypeptides, nucleic acids, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. Another aspect of the present invention involves antibodies and other ligands which recognize p115 Rho-GEF, regulators of p115 Rho-GEF activity, and methods of treating pathological conditions associated or related to a Rho GTPase.

摘要翻译： 本发明涉及鸟嘌呤交换因子（GEF），例如Rho-GEF，例如p15Rho-GEF的所有方面。 通过调节GTP酶的活性，GEF在体外和体内调节细胞信号通路。 作为说明，描述了调节Rho GTP酶的活性的p115Rho-GEF。 然而，本发明涉及其他GEF，特别是其他Rho-GEF。 本发明特别涉及分离的p115Rho-GEF多肽或其片段，编码p115Rho-GEF或其片段的核酸，以及多肽和核酸的衍生物。 本发明还涉及使用此类多肽，核酸或其衍生物的方法，例如在治疗学，诊断学和研究工具中。 本发明的另一方面涉及识别p115Rho-GEF，p115Rho-GEF活性的调节剂以及治疗与Rho GTP酶相关或相关的病理学病症的方法的抗体和其它配体。

公开(公告)号：US07148002B2

公开(公告)日：2006-12-12

申请号：US10448162

申请日：2003-05-27

申请人： Matthew J. Hart

发明人： Matthew J. Hart

IPC分类号： C12Q1/00 ,  C12Q1/48

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12Q1/6876

摘要： The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates the activity of a Rho GTPase, is described. However, the present invention relates to other GEFs, especially other Rho-GEFs. The present invention particularly relates to an isolated p115 Rho-GEF polypeptide or fragments of it, a nucleic acid coding for p115 Rho-GEF or fragments of it, and derivatives of the polypeptide and nucleic acid. The invention also relates to methods of using such polypeptides, nucleic acids, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. Another aspect of the present invention involves antibodies and other ligands which recognize p115 Rho-GEF, regulators of p115 Rho-GEF activity, and methods of treating pathological conditions associated or related to a Rho GTPase.

公开(公告)号：US06238881B1

公开(公告)日：2001-05-29

申请号：US08943768

申请日：1997-10-06

申请人： Matthew J. Hart

发明人： Matthew J. Hart

IPC分类号： C12N900

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K48/00 ,  C07K14/82 ,  C12Q1/6876

摘要： The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates the activity of a Rho GTPase, is described. However, the present invention relates to other GEFs, especially other Rho-GEFs. The present invention particularly relates to an isolated p115 Rho-GEF polypeptide or fragments of it, a nucleic acid coding for p115 Rho-GEF or fragments of it, and derivatives of the polypeptide and nucleic acid. The invention also relates to methods of using such polypeptides, nucleic acids, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. Another aspect of the present invention involves antibodies and other ligands which recognize p115 Rho-GEF, regulators of p115 Rho-GEF activity, and methods of treating pathological conditions associated or related to a Rho GTPase.

摘要翻译： 本发明涉及鸟嘌呤交换因子（GEF），例如Rho-GEF，例如p15Rho-GEF的所有方面。 通过调节GTP酶的活性，GEF在体外和体内调节细胞信号通路。 作为说明，描述了调节Rho GTP酶的活性的p115Rho-GEF。 然而，本发明涉及其他GEF，特别是其他Rho-GEF。 本发明特别涉及分离的p115Rho-GEF多肽或其片段，编码p115Rho-GEF或其片段的核酸，以及多肽和核酸的衍生物。 本发明还涉及使用此类多肽，核酸或其衍生物的方法，例如在治疗学，诊断学和研究工具中。 本发明的另一方面涉及识别p115Rho-GEF，p115Rho-GEF活性的调节剂以及治疗与Rho GTP酶相关或相关的病理学病症的方法的抗体和其它配体。