公开(公告)号：US08313920B2

公开(公告)日：2012-11-20

申请号：US12603372

申请日：2009-10-21

Applicant: Matthew Olson ,  Matthew Todd

Inventor： Matthew Olson ,  Matthew Todd

IPC: C12Q1/37 ,  A61K38/00

CPC classification number: C12Q1/37 ,  C07K5/06026 ,  C12N9/6483 ,  C12Y304/23004 ,  G01N2333/948 ,  G01N2500/02

Abstract: A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.

Abstract translation: 筛选调节二肽基肽酶I（DPPI）活性的化合物的方法包括以下步骤：将DPPI的肽底物加入到包含DPPI和化合物的反应混合物中，其中DPPI的肽底物具有至少3个氨基酸并且结合 除了S1-S2位点之外，还与DPPI的结合位点; 并测量底物的分子量，其中底物分子量的变化表明存在DPPI活性。

公开(公告)号：US20100136594A1

公开(公告)日：2010-06-03

申请号：US12603372

申请日：2009-10-21

Applicant: Matthew Olson ,  Matthew Todd

Inventor： Matthew Olson ,  Matthew Todd

IPC: C12Q1/37 ,  C12N9/48

CPC classification number: C12Q1/37 ,  C07K5/06026 ,  C12N9/6483 ,  C12Y304/23004 ,  G01N2333/948 ,  G01N2500/02

Abstract: A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.

Abstract translation: 筛选调节二肽基肽酶I（DPPI）活性的化合物的方法包括以下步骤：将DPPI的肽底物加入到包含DPPI和化合物的反应混合物中，其中DPPI的肽底物具有至少3个氨基酸并且结合 除了S1-S2位点之外，还与DPPI的结合位点; 并测量底物的分子量，其中底物分子量的变化表明存在DPPI活性。

公开(公告)号：US20090229160A1

公开(公告)日：2009-09-17

申请号：US12309019

申请日：2005-02-14

Applicant: William Elliott ,  Matthew Olson ,  James Kilham

Inventor： William Elliott ,  Matthew Olson ,  James Kilham

IPC: F41C23/12 ,  F41C23/04

CPC classification number: F41A23/04 ,  F41A23/18 ,  F41C23/20 ,  F41C33/001

Abstract: A weapon ball-and-socket-based weapon mounting system for removably attaching a to the body of a user. A ball stock adapted to be attached to a weapon at one end and configured with a substantially ball-shaped ball element on the other end replaced the conventional weapon butt stock. The ball stock mates with a body-supported socket adapted to receive the ball element by clicking in to the socket. The user is able to articulate the weapon into a rest position as well as rotating it through a full range of elevation and sweeping orientations.

Abstract translation: 一种用于可拆卸地附接到使用者身体的武器基于球 - 插座的武器安装系统。 适于在一端附接到武器并且在另一端上配置有基本上球形的球形元件的球杆替换了常规武器对接物料。 球杆与身体支撑的插座配合，适用于通过点击插座来接收球形元件。 用户能够将武器表达为静止位置，并将其旋转通过全范围的仰角和扫掠方向。

公开(公告)号：US07563905B2

公开(公告)日：2009-07-21

申请号：US11076960

申请日：2005-03-11

Applicant: Matthew Olson ,  Martin Di Grandi

Inventor： Matthew Olson ,  Martin Di Grandi

IPC: C07D249/08

CPC classification number: C07D409/04 ,  C07D249/12 ,  C07D401/04 ,  C07D405/04

Abstract: The present invention is directed to compounds of formula (I): wherein R1, R2 and R3 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl and X1 and X2 are independently a bond or an linker group of 1 to 6 atoms and may be optional substituted or oxidized, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof. The invention is also directed to methods of using the same for treating HIV infections, or AIDs or preventing viral replication.

Abstract translation: 本发明涉及式（I）化合物：其中R 1，R 2和R 3独立地选自烷基，烯基，炔基，环烷基，芳基和杂芳基，X 1和X 2独立地是键或连接基团 1至6个原子，并且可以是任选的取代或氧化的，或其前药，药学上可接受的盐或其药物活性代谢物。 本发明还涉及使用该方法治疗HIV感染或AID或预防病毒复制的方法。

公开(公告)号：US20050203176A1

公开(公告)日：2005-09-15

申请号：US11076929

申请日：2005-03-11

Applicant: Matthew Olson ,  Martin Grandi ,  Amarnauth Prashad

Inventor： Matthew Olson ,  Martin Grandi ,  Amarnauth Prashad

IPC: A61K31/325 ,  C07C333/20 ,  C07C333/24

CPC classification number: C07C333/20 ,  C07C333/24

Abstract: The present invention relates to carbamate derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer.

Abstract translation: 本发明涉及具有RNA酶H，聚合酶和/或HIV逆转录酶调节的氨基甲酸酯衍生物，特别涉及抑制活性。 本发明包括氨基甲酸酯衍生物，含有衍生物的组合物，衍生物的合成方法，鉴定衍生物的筛选方法以及使用氨基甲酸酯衍生物的治疗方法，包括治疗HIV，AIDS和逆转录病毒相关癌症。

公开(公告)号：US06349166B1

公开(公告)日：2002-02-19

申请号：US09222260

申请日：1998-12-28

Applicant: Andrew Kaliszek ,  Matthew Olson

Inventor： Andrew Kaliszek ,  Matthew Olson

IPC: G02B616

CPC classification number: G02B6/4457 ,  G01C19/722

Abstract: An adhesive system for use in minimizing the negative environmental influences on a fiber optic gyroscope comprises a free-standing substantially cylindrical sensing coil 12 having an inner coil surface, a rigid substantially cylindrical coil-supporting structure or hub 10 having a cylindrical wall and an outer surface, a plurality of grooves 16 formed into the hub's outer surface, a plurality of slots 24 formed into the outer surface of hub 10 and an adhesive 14 affixing hub 10 to coil 12. Adhesive 14 may be injected into manifolds 18 located in the cylindrical wall of hub 10, travel through the slots 24 into a gap existing between coil 12 and hub 10. Excess adhesive 14 may flow into grooves 16. Different orientations and sizes of grooves 16 and slots 24, different types and amounts of adhesive 14, and different thicknesses of adhesive between the coil 12 and hub 10 may be used to achieve suitable adhesion. The adhesive system may further include a stress buffer 22 and an additional adhesive 20 to further minimize environmental influences on coil 12. Specifically, a first adhesive 14 affixes the inner surface of buffer 22 to the outer surface of hub 10. A second adhesive 20 affixes the outer surface of buffer 22 to the inner surface of coil 12.

Abstract translation: 用于最小化对光纤陀螺仪的负面环境影响的粘合剂系统包括具有内部线圈表面的独立的大致圆柱形的感测线圈12，具有圆柱形壁和外部线圈支撑结构的刚性大致圆柱形的线圈支撑结构或轮毂10 表面，形成在毂的外表面中的多个槽16，形成在轮毂10的外表面中的多个槽24和将轮毂10固定到线圈12的粘合剂14.粘合剂14可以被注入到位于圆柱体 轮毂10的壁穿过狭槽24进入线圈12和轮毂10之间的间隙中。过多的粘合剂14可能流入凹槽16.凹槽16和狭槽24的不同取向和尺寸，不同类型和数量的粘合剂14和 可以使用线圈12和轮毂10之间的不同厚度的粘合剂来实现合适的粘附。 粘合剂系统还可以包括应力缓冲器22和附加粘合剂20，以进一步最小化对线圈12的环境影响。具体地，第一粘合剂14将缓冲器22的内表面固定到轮毂10的外表面。第二粘合剂20固定 缓冲器22的外表面到线圈12的内表面。

公开(公告)号：US20150348170A1

公开(公告)日：2015-12-03

申请号：US14288270

申请日：2014-05-27

Applicant: Christopher Alan Wilber ,  Matthew Olson ,  Imad Jabbour ,  Vipul Govil

Inventor： Christopher Alan Wilber ,  Matthew Olson ,  Imad Jabbour ,  Vipul Govil

IPC: G06Q30/06 ,  G06F17/24 ,  G06F17/30 ,  G06Q30/02

CPC classification number: G06Q30/0635 ,  G06Q30/0255

Abstract: Systems and methods are presented for facilitating entertainment media listings using unique user identifiers. In some embodiments, a computer-implemented method is presented. The method may include accessing a unique user identifier of a user, the unique user identifier associated with at least one form of entertainment media, the unique user identifier including a user history of at least one form of the entertainment media accessed by the user. The method may also include transmitting first information for displaying an offer to conduct a consumer transaction of a product associated with the at least one form of entertainment media, wherein displaying the offer is based on the user history within the accessed unique user identifier.

Abstract translation: 介绍了使用独特的用户标识符来促进娱乐媒体列表的系统和方法。 在一些实施例中，呈现计算机实现的方法。 该方法可以包括访问用户的唯一用户标识符，与至少一种形式的娱乐媒体相关联的唯一用户标识符，唯一用户标识符包括由用户访问的娱乐媒体的至少一种形式的用户历史。 该方法还可以包括发送用于显示提供的第一信息以进行与至少一种娱乐媒体形式相关联的产品的消费者交易，其中，显示提供是基于所访问的唯一用户标识符内的用户历史。

公开(公告)号：US20140129612A1

公开(公告)日：2014-05-08

申请号：US14075582

申请日：2013-11-08

Applicant: Scot Fraser Hamilton ,  Ladd Van Tol ,  Luke Shardlow ,  Jonathan David Chard ,  Matthew Olson

Inventor： Scot Fraser Hamilton ,  Ladd Van Tol ,  Luke Shardlow ,  Jonathan David Chard ,  Matthew Olson

IPC: H04L29/08

CPC classification number: H04W4/50 ,  G06F3/1454 ,  G09G2370/022 ,  G09G2370/027 ,  H04L67/025 ,  H04L67/38 ,  H04W76/10

Abstract: Methods, systems, and apparatus for providing assistance to a user of a mobile application are described. A request for assistance from the user is detected and a request is issued to a remote device for establishment of a remote assistance session. Information describing a state of the mobile device is periodically transmitted to the remote device and one or more commands may be received from the remote device. The commands may be executed on the mobile device.

Abstract translation: 描述了用于向移动应用的用户提供帮助的方法，系统和装置。 检测到来自用户的帮助的请求，并且向远程设备发出请求以建立远程协助会话。 描述移动设备的状态的信息被周期地发送到远程设备，并且可以从远程设备接收一个或多个命令。 命令可以在移动设备上执行。

公开(公告)号：US07553967B2

公开(公告)日：2009-06-30

申请号：US11076936

申请日：2005-03-11

Applicant: Matthew Olson ,  Martin Di Grandi ,  Amarnauth Prashad

Inventor： Matthew Olson ,  Martin Di Grandi ,  Amarnauth Prashad

IPC: C07D215/38

CPC classification number: C07D215/48 ,  C07D215/08

Abstract: The present invention is directed to compound of formula (A): wherein R1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl, or (b) CN and —C(NR10R11)═N—R12, R2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, R3-R12 are as described within the specification, and A is O, NR9 or S, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof, provided that R1 is not alkyl when R2 is pyridine, provided that at least one of R3-R8 is not H or F when A is O, R1 is (b) and R2 is a phenyl ring, a phenyl ring substituted at the para position with halo, —CN, —OCH3, —CF3 or —CO2CH3, a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety, provided that R4 is not methyl when R3 and R5-R8 are H, A is O, R1 is (b) and R2 is 4-chlorophenyl, and provided that R6 is not Cl when R3-R5 and R7-R8 are H, R1 is CN and R2 is phenyl. This invention is also directed to methods of using the same for treating HIV infections, or AIDS, or preventing replication.

Abstract translation: 本发明涉及式（A）的化合物：其中R1选自（a）烷基，烯基，炔基，环烷基，芳基和杂芳基，或（b）CN和-C（NR10R11）-N-R12， R 2选自烷基，烯基，炔基，环烷基，芳基和杂芳基，R 3 -R 12如说明书中所述，A是O，NR 9或S，或前药，药学上可接受的盐或药学上可接受的盐 条件是当R 2为吡啶时R 1不为烷基，条件是当A为O时，R 3 -R 8中的至少一个不为H或F，R 1为（b）且R 2为苯环，苯环取代 在具有卤素的对位，-CN，-OCH 3，-CF 3或-CO 2 CH 3，喹啉或被苯环或3,4-亚甲二氧基苯基部分取代的亚乙基，条件是当R 3和R 5 -R 8 是H，A是O，R 1是（b），R 2是4-氯苯基，条件是当R 3 -R 5和R 7 -R 8是H时，R 6不是Cl，R 1是CN，R 2是苯基。 本发明还涉及使用该方法治疗HIV感染或AIDS或预防复制的方法。

公开(公告)号：US08997473B2

公开(公告)日：2015-04-07

申请号：US13091579

申请日：2011-04-21

Applicant: Matthew Olson ,  James Prazak

Inventor： Matthew Olson ,  James Prazak

IPC: F15B21/04 ,  F15B7/00 ,  F15B15/18

CPC classification number: F15B7/006 ,  F15B15/18 ,  F15B2211/20561 ,  F15B2211/27 ,  F15B2211/3051 ,  F15B2211/40515 ,  F15B2211/50518

Abstract: An electro-hydraulic actuator (EHA) includes a hydraulic circuit having a plurality of pressure compensated flow control valves for limiting the maximum flow rate through the fluid conduits regardless of the loads imparted on the actuator. In one embodiment of the EHA, a plurality of combination manual override/thermal expansion valves that simplify the manufacture of the EHA.

Abstract translation: 电动液压致动器（EHA）包括具有多个压力补偿流量控制阀的液压回路，用于限制通过流体导管的最大流量，而不管施加在致动器上的载荷如何。 在EHA的一个实施例中，多个组合手动超控/热膨胀阀，其简化了EHA的制造。