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公开(公告)号：US20070219437A1
公开(公告)日：2007-09-20
申请号：US11378538
申请日：2006-03-17
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0066 , A61B5/14532 , A61B5/6832 , A61B5/6833 , A61B2562/146
摘要： A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.
摘要翻译： 用于产生用于测量生物组织中的血糖水平的光学传感器系统的稳定且可再现的界面的系统和方法包括附接到包括聚焦透镜和光学窗口的一次性光学元件的双楔形棱镜传感器。 一次性光学器件粘附到皮肤上，以允许患者在相同位置进行多次读数或扫描。 一次性光学元件包括与皮肤平齐地放置的保持光泽的焦点在皮肤表面上的Petzval表面。 此外，传感器信号的完整性通过相对于传感器的深度扫描速率改变双楔形棱镜随时间的旋转速率而最大化。 最佳地，可以在一次性和皮肤之间注入介质以匹配各自的折射率并优化传感器的信号收集。
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2.发明申请公开(公告)号：US20060063988A1
公开(公告)日：2006-03-23
申请号：US10916236
申请日：2004-08-11
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , A61B5/0064 , A61B5/14532 , A61B5/441
摘要： In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.
摘要翻译： 根据本发明，低相干干涉仪用于通过在人或动物组织的表面区域上照射光而不间断地监测血液中葡萄糖的浓度，连续扫描光在表面的二维区域上， 收集来自组织内的反射光，并用沿着参考路径反射的光建构性地干涉该反射光以深度地扫描组织。 由于反射光谱对特定波长的葡萄糖浓度敏感，反射光的测量和分析提供血液中葡萄糖水平的量度。 葡萄糖的测量取自血液灌注组织内的多个深度，并且灵敏度优选通过使用多个波长来增强。 通过在区域和深度中连续扫描照射的组织来最小化与该技术相关的噪声或斑点。
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3.发明申请公开(公告)号：US20080021293A1
公开(公告)日：2008-01-24
申请号：US11832721
申请日：2007-08-02
CPC分类号： A61B5/0066 , A61B5/0064 , A61B5/14532 , A61B5/441
摘要： In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.
摘要翻译： 根据本发明，低相干干涉仪用于通过在人或动物组织的表面区域上照射光而不间断地监测血液中葡萄糖的浓度，连续扫描光在表面的二维区域上， 收集来自组织内的反射光，并用沿着参考路径反射的光建构性地干涉该反射光以深度地扫描组织。 由于反射光谱对特定波长的葡萄糖浓度敏感，反射光的测量和分析提供血液中葡萄糖水平的量度。 葡萄糖的测量取自血液灌注组织内的多个深度，并且灵敏度优选通过使用多个波长来增强。 通过在区域和深度中连续扫描照射的组织来最小化与该技术相关的噪声或斑点。
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公开(公告)号：US20060276696A1
公开(公告)日：2006-12-07
申请号：US11445631
申请日：2006-06-02
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0066 , A61B5/14532 , A61B2560/0223
摘要： A method for noninvasively measuring analytes such as blood glucose levels includes using a non-imaging OCT-based system to scan a two-dimensional area of biological tissue and gather data continuously during the scanning. Structures within the tissue where measured-analyte-induced changes to the OCT data dominate over changes induced by other analytes are identified by focusing on highly localized regions of the data curve produced from the OCT scan which correspond to discontinuities in the OCT data curve. The data from these localized regions then can be related to measured analyte levels.
摘要翻译： 用于非侵入性测量分析物（例如血糖水平）的方法包括使用非成像OCT基系统来扫描生物组织的二维区域并在扫描期间连续收集数据。 组织内的测量分析物诱导的OCT数据变化主要受其他分析物诱导的变化的结构，通过聚焦于从OCT扫描产生的对应于OCT数据曲线中的不连续性的数据曲线的高度局部化区域来识别。 然后来自这些局部区域的数据可以与测量的分析物水平相关。
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5.发明申请Method for data reduction and calibration of an OCT-based blood glucose monitor 有权OCT基础血糖监测仪的数据减少和校准方法公开(公告)号：US20060264719A1
公开(公告)日：2006-11-23
申请号：US11403635
申请日：2006-04-13
CPC分类号： A61B5/1455 , A61B5/0066 , A61B5/14532 , A61B5/441 , A61B5/72 , A61B5/7246 , A61B5/7278 , A61B2560/0223
摘要： The present invention relates to a method for estimating blood glucose levels using a noninvasive optical coherence tomography- (OCT-) based blood glucose monitor. An algorithm correlates OCT-based estimated blood glucose data with actual blood glucose data determined by invasive methods. OCT-based data is fit to the obtained blood glucose measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood glucose levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based blood glucose monitor is calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.
摘要翻译： 本发明涉及使用基于无创光学相干断层摄影（OCT）的血糖监测器估计血糖水平的方法。 一种算法将基于OCT的估计血糖数据与通过侵入性方法确定的实际血糖数据相关联。 基于OCT的数据适合于获得的血糖测量值以达到最佳相关性。 一旦算法产生了估计血糖水平的集合，它可以通过应用一个或多个数学滤波器来细化集合的数量。 基于OCT的血糖监测器使用强度差分图或Pearson积分相关方法进行校准。
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公开(公告)号：US20050186648A1
公开(公告)日：2005-08-25
申请号：US11040388
申请日：2005-01-21
CPC分类号： A61B5/0066 , A61B5/14532
摘要： This invention relates to a method of diagnosing or treating a biological subject, such as a person or animal, comprising the steps of subjecting at least a microsample of the subject's tissue to a physiological perturbation and measuring the response of the microsample to the perturbation using optical coherence tomography (OCT). In an exemplary embodiment, the concentration of glucose in the microsample is perturbed, as by providing the subject with a high glucose drink, and subsequently monitoring at a high sample rate in a microsample by OCT. Pathology, such as diabetes, can be diagnosed by deviation of the concentration vs. time response over several cells (micro-oscillation) from the micro-oscillation in the cells of a healthy subject. Other applications include diagnosing or treating de-hydration and diseases that cause changes in the osmolyte concentrations and thus the osmotic pressure in the cells in tissue.
摘要翻译： 本发明涉及诊断或治疗诸如人或动物的生物学对象的方法，包括以下步骤：使受试者的组织的至少一个微样本受到生理扰动，并使用光学测量微量样品对扰动的响应 相干断层扫描（OCT）。 在一个示例性实施方案中，通过向受试者提供高葡萄糖饮料，随后通过OCT在微量样品中以高采样率进行监测，扰动微量样品中葡萄糖的浓度。 病理学，如糖尿病，可以从健康受试者的细胞中的微振荡的几个细胞（微振荡）的浓度对时间响应的偏差来诊断。 其他应用包括诊断或治疗脱水和导致渗透液浓度变化，从而引起组织细胞渗透压的疾病。
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公开(公告)号：US20050059868A1
公开(公告)日：2005-03-17
申请号：US10884298
申请日：2004-07-02
申请人： Matthew Schurman
发明人： Matthew Schurman
IPC分类号： A61B5/00 , A61M20060101
CPC分类号： A61B5/0066 , A61B5/14551
摘要： In accordance with the invention, the oxygenation of blood-profused tissue is measured by shining light into the profused tissue and analyzing the light reflected within the tissue. The light is reflected by cell walls in the tissue and is partially absorbed by hemoglobin in the blood. Since the extent of absorption is sensitive to the extent of hemoglobin oxygenation, measurement and processing of the reflected light provides a measure of the oxygenation of the blood. In one embodiment, the method is applied to measure the oxygenation of blood within the tympanic membrane (ear drum).
摘要翻译： 根据本发明，通过将光照射到多余的组织中并分析在组织内反射的光来测量血液灌注组织的氧合。 光被组织中的细胞壁反射，并被血液中的血红蛋白部分吸收。 由于吸收程度对血红蛋白氧合程度敏感，所以反射光的测量和处理提供了血液氧合作用的量度。 在一个实施方案中，该方法用于测量鼓膜内的血液的氧合作用。
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