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![2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS](/abs-image/US/2009/04/02/US20090088569A1/abs.jpg.150x150.jpg)
1.发明申请2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 审中-公开2-氨基咪唑并[4,5-D]吡啶-4-酮，其制备方法及其作为药物组合物的用途公开(公告)号：US20090088569A1
公开(公告)日：2009-04-02
申请号：US12328902
申请日：2008-12-05
申请人： Matthias ECKHARDT , Frank HIMMELSBACH , Elke LANGKOPF , Norbert HAUEL , Mohammad TADAYYON , Leo THOMAS
发明人： Matthias ECKHARDT , Frank HIMMELSBACH , Elke LANGKOPF , Norbert HAUEL , Mohammad TADAYYON , Leo THOMAS
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula wherein R1 to R4 and X are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及以下通式的2-氨基 - 咪唑并[4,5-d]哒嗪-4-酮和2-氨基 - 咪唑并[4,5-c]吡啶-4-酮，其中R1至R4和X为 如权利要求1至6中定义的互变异构体，对映异构体，非对映体，其混合物及其盐，其具有有价值的药理学性质，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。
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2.发明申请IMIDAZOPYRIDAZINONE AND IMIDAZOPYRIDONE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权咪达唑嗪酮和咪唑吡啶衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20090258856A1
公开(公告)日：2009-10-15
申请号：US12489716
申请日：2009-06-23
申请人： Matthias ECKHARDT , Norbert HAUEL , Elke LANGKOPF , Frank HIMMELSBACH , Iris KAUFFMANN-HEFNER , Mohammad TADAYYON , Michael MARK
发明人： Matthias ECKHARDT , Norbert HAUEL , Elke LANGKOPF , Frank HIMMELSBACH , Iris KAUFFMANN-HEFNER , Mohammad TADAYYON , Michael MARK
IPC分类号： A61K31/554 , C07D401/14 , A61K31/437 , A61P3/10 , A61P19/02 , A61P3/04 , A61P19/10 , A61P37/06 , A61K31/5025 , A61K31/517 , C07D413/14 , A61K31/536 , C07D417/14 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/553
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代的咪唑并 - 吡啶酮和咪唑并哒嗪酮，其中Y和R 1至R 4如权利要求1所定义，互变异构体，对映异构体，非对映异构体，其混合物及其盐具有有价值的药理学性质， 特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。
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3.发明申请IMIDAZOLES AND TRIAZOLES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权咪唑和三唑，其制备及其作为药物组合物的用途公开(公告)号：US20080312243A1
公开(公告)日：2008-12-18
申请号：US12192589
申请日：2008-08-15
IPC分类号： A61K31/4439 , A61K31/498 , A61P3/10
CPC分类号： C07D471/04 , C07D249/14 , C07D401/04 , C07D401/12 , C07D401/14
摘要： The present invention relates to imidazoles and triazoles of general formula wherein R1 to R4 and X are defined as in claims 1 to 8, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的咪唑和三唑，其中R 1至R 4和X如权利要求1至8中所定义，互变异构体，对映异构体，非对映异构体，其混合物及其盐具有有价值的药理学性质，特别是 对二肽基肽酶-IV（DPP-IV）的活性具有抑制作用。
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![8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS](/abs-image/US/2009/05/28/US20090137801A1/abs.jpg.150x150.jpg)
4.发明申请8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权8- [3-氨基哌啶-1-基] - 辛糖，其制备及其作为药物组合物的用途公开(公告)号：US20090137801A1
公开(公告)日：2009-05-28
申请号：US12360392
申请日：2009-01-27
IPC分类号： C07D473/04
CPC分类号： C07D473/04
摘要： Disclosed are substituted xanthines of the formula wherein R is defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 公开了下式的取代黄嘌呤：其中R如权利要求1所定义，互变异构体，立体异构体，其混合物及其盐具有有价值的药理学性质，特别是对二肽基肽酶-IV酶活性的抑制作用 DPP-IV）。
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![8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions](/abs-image/US/2012/08/16/US20120208831A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120208831A1
公开(公告)日：2012-08-16
申请号：US13448495
申请日：2012-04-17
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf R. H. LOTZ , Mohammad TADAYYON
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf R. H. LOTZ , Mohammad TADAYYON
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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6.发明申请XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 审中-公开XANTHINE衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20100144703A1
公开(公告)日：2010-06-10
申请号：US12706739
申请日：2010-02-17
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
IPC分类号： A61K31/553 , C07D473/04 , A61K31/522 , A61K31/5513 , A61K31/554
CPC分类号： C07D473/06
摘要： Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 公开了以下通式的取代黄嘌呤：其中R1至R4定义如下，其互变异构体，立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对酶二肽基肽酶的活性的抑制作用 -IV（DPP-IV）。
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7.发明申请XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权XANTHINE衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20090093457A1
公开(公告)日：2009-04-09
申请号：US12331720
申请日：2008-12-10
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
IPC分类号： A61K31/522 , C07D473/04 , C07D265/14 , C07D279/16 , A61K31/54 , A61K31/554 , A61P3/00 , A61K31/5513 , A61K31/536 , C07D243/12 , C07D285/36
CPC分类号： C07D473/06
摘要： Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 公开了以下通式的取代黄嘌呤：其中R1至R4定义如下，其互变异构体，立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对酶二肽基肽酶的活性的抑制作用 -IV（DPP-IV）。
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![8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS](/abs-image/US/2014/05/08/US20140128604A1/abs.jpg.150x150.jpg)
8.发明申请8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权8- [3-氨基 - 哌啶-1-基] - 辛糖，其制备方法及其作为药物组合物的用途公开(公告)号：US20140128604A1
公开(公告)日：2014-05-08
申请号：US14154885
申请日：2014-01-14
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
IPC分类号： C07D473/04
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式为其中R1至R3如本文所定义的取代黄嘌呤，其互变异构体，立体异构体，混合物，其前药及其盐具有有价值的药理学性质，特别是对 酶二肽肽酶-IV（DPP-IV）。
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