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公开(公告)号：US20080194512A1
公开(公告)日：2008-08-14
申请号：US11959936
申请日：2007-12-19
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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公开(公告)号：US07348314B2
公开(公告)日：2008-03-25
申请号：US10384512
申请日：2003-03-07
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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公开(公告)号：US08273868B2
公开(公告)日：2012-09-25
申请号：US12631689
申请日：2009-12-04
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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公开(公告)号：US07745418B2
公开(公告)日：2010-06-29
申请号：US11959936
申请日：2007-12-19
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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公开(公告)号：US20130064879A1
公开(公告)日：2013-03-14
申请号：US13594150
申请日：2012-08-24
IPC分类号： A61K31/713 , A61K9/127 , A61P31/14 , C07H21/02
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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公开(公告)号：US20100316699A1
公开(公告)日：2010-12-16
申请号：US12631689
申请日：2009-12-04
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
摘要翻译： 本发明涉及具有长度小于30个核苷酸的核苷酸序列的双链核糖核酸（dsRNA），并且其基本上与3'非翻译区（3'-UTR）的至少一部分相同 （+）链RNA病毒，例如HCV，以及包含dsRNA的药物组合物，以及药学上可接受的载体。 药物组合物可用于治疗由（+）链RNA病毒的复制或活性引起的感染和疾病以及用于抑制病毒复制的方法。
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7.发明授权公开(公告)号：US07786290B2
公开(公告)日：2010-08-31
申请号：US10560336
申请日：2004-06-14
CPC分类号： C12N15/1135 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2330/30
摘要： The present invention relates to a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, wherein at least end of the dsRNA comprises a nucleotide overhang of 1 to 4 unpaired nucleotides in length; wherein the unpaired nucleotide adjacent to the terminal nucleotide pair comprises a purine base; and wherein the terminal nucleotide pair on both ends of the dsRNA is a G-C pair, or at least two of the last four consecutive terminal nucleotide pairs are G-C pairs.
摘要翻译： 本发明涉及一种靶向选择双链核糖核酸（dsRNA）的方法，所述双链核糖核酸（dsRNA）由两条单链组成，其通过RNA干扰显示增强的抑制靶基因表达的有效性，其中至少 dsRNA包含长度为1至4个不成对核苷酸的核苷酸突出端; 其中与所述末端核苷酸对相邻的未配对核苷酸包含嘌呤碱基; 并且其中dsRNA两端的末端核苷酸对是G-C对，或者最后四个连续的末端核苷酸对中的至少两个是G-C对。
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8.发明申请DOUBLE-STRANDED RIBONUCLEIC ACID WITH INCREASED EFFECTIVENESS IN AN ORGANISM 审中-公开双重有效的抗坏血酸在有机体中具有更高的有效性公开(公告)号：US20100280102A1
公开(公告)日：2010-11-04
申请号：US12816994
申请日：2010-06-16
CPC分类号： C12N15/1135 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2330/30
摘要： The present invention relates to a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, wherein at least end of the dsRNA comprises a nucleotide overhang of 1 to 4 unpaired nucleotides in length; wherein the unpaired nucleotide adjacent to the terminal nucleotide pair comprises a purine base; and wherein the terminal nucleotide pair on both ends of the dsRNA is a G-C pair, or at least two of the last four consecutive terminal nucleotide pairs are G-C pairs.
摘要翻译： 本发明涉及一种靶向选择双链核糖核酸（dsRNA）的方法，所述双链核糖核酸（dsRNA）由两条单链组成，其通过RNA干扰显示增强的抑制靶基因表达的有效性，其中至少 dsRNA包含长度为1至4个不成对核苷酸的核苷酸突出端; 其中与所述末端核苷酸对相邻的未配对核苷酸包含嘌呤碱基; 并且其中dsRNA两端的末端核苷酸对是G-C对，或者最后四个连续的末端核苷酸对中的至少两个是G-C对。
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9.发明申请公开(公告)号：US20070275465A1
公开(公告)日：2007-11-29
申请号：US10560336
申请日：2004-06-14
IPC分类号： C07H21/02
CPC分类号： C12N15/1135 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2330/30
摘要： The invention concerns a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, whereby the sequences of the single strands of the dsRNA are selected in such a way that on both ends of the dsRNA the last complementary nucleotide pair is a G-C, or at least two of the last four complementary nucleotide pairs are G-C pairs; whereby the dsRNA exhibits a single-stranded overhang consisting of 1 to 4 unpaired nucleotides at the first end, and no overhang at the second end; whereby the unpaired nucleotide of the single-stranded overhang that is directly adjacent to the last complementary nucleotide pair contains a purine base.
摘要翻译： 本发明涉及一种靶向选择双链核糖核酸（dsRNA）的方法，该双链核糖核酸（dsRNA）由两条单链组成，其通过RNA干扰显示增强的抑制靶基因表达的有效性，由此单链 选择dsRNA，使得在dsRNA的两端，最后一个互补核苷酸对是GC，或者最后四个互补核苷酸对中的至少两个是GC对; 由此dsRNA在第一端显示由1至4个不成对核苷酸组成的单链突出端，并且在第二末端没有突出端; 其中与最后的互补核苷酸对直接相邻的单链突出端的不成对核苷酸包含嘌呤碱基。
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公开(公告)号：US20060178324A1
公开(公告)日：2006-08-10
申请号：US10543048
申请日：2004-01-21
CPC分类号： C12N15/1131 , A61K38/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/3515 , C12N2310/53 , C12N2320/32 , C12N2320/50
摘要： The present invention relates to a double-stranded ribonucleic acid (dsRNA) having improved efficiency of inhibition of gene expression, methods of making the dsRNA, and pharmaceutical compositions comprising the dsRNA. The dsRNA comprises an RNA strand (complementary RNA strand) having a region which is complementary to an RNA transcript of at least a part of a target gene, and at least one covalently linked lipophilic group. The dsRNA are useful for inhibiting the expression of a target gene, as well as for treating diseases caused by expression of the target gene. The invention also relates to methods for inhibiting the expression of a target gene, as well as methods for treating diseases caused by the expression of the gene.
摘要翻译： 本发明涉及具有改善的基因表达抑制效率的双链核糖核酸（dsRNA），制备dsRNA的方法和包含dsRNA的药物组合物。 dsRNA包含具有与靶基因的至少一部分的RNA转录物互补的区域的RNA链（互补RNA链）和至少一个共价连接的亲脂基团。 dsRNA可用于抑制靶基因的表达，以及用于治疗由靶基因表达引起的疾病。 本发明还涉及抑制靶基因表达的方法，以及用于治疗由基因表达引起的疾病的方法。
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