-
公开(公告)号：US06475763B1
公开(公告)日：2002-11-05
申请号：US09487716
申请日：2000-01-19
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madlene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Shlomi
IPC分类号： C12Q100
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
-
2.发明授权Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same 有权用于表达重组肝素酶的转基因细胞和方法及其纯化方法公开(公告)号：US06348344B1
公开(公告)日：2002-02-19
申请号：US09260038
申请日：1999-03-02
申请人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
发明人： Maty Ayal-Hershkovitz , Haim Moskowitz , Daphna Miron , Ayelet Gilboa , Madelene Mimon , Hanna Ben-Artzi , Oron Yacoby-Zeevi , Iris Pecker , Yoav Peleg , Yinon Schlomi
IPC分类号： C12N942
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： Bacterial, yeast and animal cells and methods for overexpressing recombinant heparanase in cellular systems, methods of purifying recombinant heparanase therefrom and modified heparanase species which serve as precursors for generating highly active heparanase by proteolysis.
摘要翻译： 细菌，酵母和动物细胞和细胞系中过表达重组肝素酶的方法，从其中纯化重组肝素酶的方法和通过蛋白水解产生高活性乙酰肝素酶的前体的修饰的乙酰肝素酶。
-
3.发明申请Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies 审中-公开肝素酶活性中和抗肝素酶单克隆抗体和其他抗肝素酶抗体公开(公告)号：US20060269552A1
公开(公告)日：2006-11-30
申请号：US10559925
申请日：2004-06-03
申请人： Oron Yacoby-Zeevi , Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz
发明人： Oron Yacoby-Zeevi , Tuvia Peretz , Daphna Miron , Yinon Shlomi , Iris Pecker , Maty Ayal-Hershkovitz
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/73 , C07K2317/76 , C12Q1/34 , G01N33/6893
摘要： Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
摘要翻译： 公开了特异性抗乙酰肝素酶抗体，其特异性结合具有与人类乙酰肝素酶具有序列同源性的乙酰肝素酶，其可用于治疗和诊断与肝素酶催化活性相关的病症，用于纯化乙酰肝素酶和用于乙酰肝素酶相关病症中的药物开发。
-
4.发明授权Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same 有权用于表达重组肝素酶的转基因细胞和方法及其纯化方法公开(公告)号：US06426209B1
公开(公告)日：2002-07-30
申请号：US09635923
申请日：2000-08-10
IPC分类号： C12N900
CPC分类号： C12Y302/01166 , A61K38/00 , C07K16/40 , C12N9/2402 , G01N33/573 , G01N2333/988 , G01N2400/40
摘要： A preparation containing an enzymatically inactive form of heparanase, said enzymatically inactive form of heparanase being cleavable into an enzimatically active form of heparanase.
摘要翻译： 含有酶促无活性形式的乙酰肝素酶的制剂，所述酶促无活性形式的乙酰肝素酶可切割成酶活性形式的乙酰肝素酶。
-
公开(公告)号：US20050260187A1
公开(公告)日：2005-11-24
申请号：US11106672
申请日：2005-04-15
申请人： Neta Ilan , Israel Vlodavsky , Oron Yacoby-Zeevi , Iris Pecker , Elena Feinstein
发明人： Neta Ilan , Israel Vlodavsky , Oron Yacoby-Zeevi , Iris Pecker , Elena Feinstein
CPC分类号： A61K38/47 , A61K31/00 , C12N9/2402 , C12Y302/01166
摘要： Methods and compositions for inducing and/or accelerating wound healing and/or angiogenesis via the catalytic activity of heparanase are disclosed.
摘要翻译： 公开了通过乙酰肝素酶的催化活性诱导和/或加速伤口愈合和/或血管生成的方法和组合物。
-
6.发明授权Use of glycosaminoglycans degrading enzymes for management of airway associated diseases 失效使用糖胺聚糖降解酶来管理气道相关疾病
公开(公告)号：US6153187A
公开(公告)日：2000-11-28
申请号：US46475
申请日：1998-03-25
申请人： Oron Yacoby-Zeevi
发明人： Oron Yacoby-Zeevi
IPC分类号： A61K9/00 , A61K38/00 , A61K38/46 , A61K38/51 , A61M15/00 , C07K16/40 , C12N9/24 , C12N15/56 , C12P21/08 , G01N33/573 , C12N9/88
CPC分类号： C07K16/40 , A61K38/51 , A61K45/06 , A61M15/009 , C12N9/2402 , C12Y302/01166 , C12Y402/02008 , G01N33/573 , A61K38/00 , A61K9/0073 , G01N2333/988 , G01N2400/40
摘要： A method of managing a patient having an accumulation of mucoid, mucopurulent or purulent material containing glycosaminoglycans, the method comprising the step of administering at least one glycosaminoglycans degrading enzyme to the patient in an amount therapeutically effective to reduce at least one of the following: the visco-elasticity of the material, pathogens infectivity and inflammation. An article of manufacture comprising an inhaler including, as an active ingredient, at least one glycosaminoglycans degrading enzyme for generating aerosols including the enzyme for management a patient having an accumulation of mucoid, mucopurulent or purulent material containing glycosaminoglycans.
摘要翻译： 一种管理具有含有糖胺聚糖的粘液性，粘液脓性或化脓性物质积累的患者的方法，所述方法包括以治疗有效减少以下至少一种的量向患者施用至少一种糖胺聚糖降解酶的步骤： 材料的粘弹性，病原体感染性和炎症。 一种包含吸入器的制品，其包括至少一种用于产生气溶胶的糖胺聚糖降解酶作为活性成分，所述降粘酶包括用于管理含有粘多糖，粘液脓性或含有糖胺聚糖的脓性物质积聚的患者的酶。
-
7.发明授权Continuous administration of dopa decarboxylase inhibitors and compositions for same 有权连续给药多巴脱羧酶抑制剂及其组合物公开(公告)号：US09101663B2
公开(公告)日：2015-08-11
申请号：US12961534
申请日：2010-12-07
申请人： Oron Yacoby-Zeevi , Mara Nemas
发明人： Oron Yacoby-Zeevi , Mara Nemas
IPC分类号： A01N33/02 , A61K31/135 , A01N37/12 , A01N37/44 , A61K31/195 , A61K31/24 , A61K47/18 , A61K9/00 , A61K31/12 , A61K31/198 , A61K31/277 , A61K47/22
CPC分类号： A61K31/198 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K31/12 , A61K31/15 , A61K31/277 , A61K47/183 , A61K47/22 , C07C243/18 , C07C279/14 , A61K2300/00
摘要： Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
摘要翻译： 本文公开了包括例如卡比多巴的精氨酸盐的组合物，以及用于治疗神经或运动疾病或障碍的方法，例如不宁腿综合征，帕金森病，继发性帕金森综合征，亨廷顿舞蹈病，帕金森氏综合症，PSP，MSA，ALS，害羞 由脑损伤（包括一氧化碳或锰中毒引起的） - 使用基本上连续施用卡比多巴或其盐以及施用左旋多巴的情况。
-
8.发明申请公开(公告)号：US20110269833A1
公开(公告)日：2011-11-03
申请号：US12961534
申请日：2010-12-07
申请人： Oron Yacoby-Zeevi , Mara Nemas
发明人： Oron Yacoby-Zeevi , Mara Nemas
IPC分类号： A61K31/277 , A61P25/16 , A61K31/198
CPC分类号： A61K31/198 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K31/12 , A61K31/15 , A61K31/277 , A61K47/183 , A61K47/22 , C07C243/18 , C07C279/14 , A61K2300/00
摘要： Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
摘要翻译： 本文公开了包括例如卡比多巴的精氨酸盐的组合物，以及用于治疗神经或运动疾病或障碍的方法，例如不宁腿综合征，帕金森病，继发性帕金森综合征，亨廷顿舞蹈病，帕金森氏综合症，PSP，MSA，ALS，害羞 由脑损伤（包括一氧化碳或锰中毒引起的） - 使用基本上连续施用卡比多巴或其盐以及施用左旋多巴的情况。
-
公开(公告)号：US20130338143A1
公开(公告)日：2013-12-19
申请号：US13885512
申请日：2011-11-15
申请人： Oron Yacoby-Zeevi , Mara Nemas , Eduardo Zawozink
发明人： Oron Yacoby-Zeevi , Mara Nemas , Eduardo Zawozink
CPC分类号： A61K31/198 , A61K9/0014 , A61K9/7023 , A61K31/137 , A61K31/138 , A61K31/167 , A61K31/195 , A61K31/277 , A61K31/407 , A61K31/4166 , A61K31/439 , A61K31/4402 , A61K31/465 , A61K31/49 , A61K31/5377 , A61K31/55 , A61K31/554 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183
摘要： Disclosed herein are compositions that are useful in effecting the transdermal delivery of therapeutic agents. More particularly, the disclosed transdermal compositions may include a fatty alcohol (for example, octanol), a terpene (for example, limonene), and an active agent comprising an amine moiety.
摘要翻译： 本文公开了可用于实现治疗剂的透皮递送的组合物。 更具体地，所公开的透皮组合物可以包括脂肪醇（例如辛醇），萜烯（例如柠檬烯）和包含胺部分的活性剂。
-
公开(公告)号：US20100298429A1
公开(公告)日：2010-11-25
申请号：US12836130
申请日：2010-07-14
申请人： Oron Yacoby-Zeevi , Mara Nemas
发明人： Oron Yacoby-Zeevi , Mara Nemas
IPC分类号： A61K31/197 , A61P25/16 , A61K31/277 , C07C243/12
CPC分类号： A61K31/198 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K31/12 , A61K31/15 , A61K31/277 , A61K47/183 , A61K47/22 , C07C243/18 , C07C279/14 , A61K2300/00
摘要： Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
-
-
-
-
-
-
-
-
-
搜索结果
18 条记录 (耗时 0.063 秒)
