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1.发明授权公开(公告)号：US06978815B2
公开(公告)日：2005-12-27
申请号：US10325444
申请日：2002-12-19
申请人： Maury D. Cosman , Kristen Billiar , Ryan Mercer , Bruce Miller
发明人： Maury D. Cosman , Kristen Billiar , Ryan Mercer , Bruce Miller
CPC分类号： A61F2/062 , B29C53/562
摘要： An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.
摘要翻译： 用于从平面片状基体形成管构造的装置包括支撑两个相对的安装件并跨过相对的安装件的支架是平行布置地保持的心轴，多孔杆和弹簧加载的辊; 用于在相对的安装件上对准和接合心轴的引导件; 以及用于在平面片基体上施加切向力以防止起皱的装置。 多孔棒具有延伸其长度的内腔，并且具有在多孔棒的内腔之间连通到杆的表面以使水均匀通过的孔。 弹簧加载的滚筒沿着多孔棒的长度延伸，在滚筒和心轴之间形成一条接触线。 心轴与平面的基质片材接触并且旋转，使得基质的连续部分接触多孔棒并被穿过多孔棒的孔的水轻轻地润湿，并且缠绕在心轴上以形成管构造 。
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2.发明申请公开(公告)号：US20070003633A1
公开(公告)日：2007-01-04
申请号：US11105963
申请日：2005-04-14
申请人： Ginger Abraham , Maury Cosman , Kristen Billiar , Ryan Mercer , Bruce Miller
发明人： Ginger Abraham , Maury Cosman , Kristen Billiar , Ryan Mercer , Bruce Miller
CPC分类号： A61F2/062 , B29C53/562
摘要： An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.
摘要翻译： 用于从平面片状基体形成管构造的装置包括支撑两个相对的安装件并跨过相对的安装件的支架是平行布置地保持的心轴，多孔杆和弹簧加载的辊; 用于在相对的安装件上对准和接合心轴的引导件; 以及用于在平面片基体上施加切向力以防止起皱的装置。 多孔棒具有延伸其长度的内腔，并且具有在多孔棒的内腔之间连通到杆的表面以使水均匀通过的孔。 弹簧加载的滚筒沿着多孔棒的长度延伸，在滚筒和心轴之间形成一条接触线。 心轴与平面的基质片材接触并且旋转，使得基质的连续部分接触多孔棒并被穿过多孔棒的孔的水轻轻地润湿，并且缠绕在心轴上以形成管构造 。
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公开(公告)号：US20120253407A1
公开(公告)日：2012-10-04
申请号：US13071155
申请日：2011-03-24
CPC分类号： A61B17/8076 , A61B17/8042
摘要： An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The locking mechanism can include a second screw to actuate and expansion portion of screw inserted into the bone. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.
摘要翻译： 用于刚性骨固定的组件包括板和螺钉。 螺钉可以在板内以非锁定构型自由旋转，以将板固定在骨上。 接合锁定机构以防止螺钉相对于板移动。 在一个实施例中，板包括螺纹部分和非螺纹部分。 螺钉头在非螺纹部分内旋转以拧紧螺钉并将板拉向骨头。 锁定机构可以包括在板的螺纹部分内旋转的可移动螺母，以将螺钉和板锁定在锁定模式。 锁定机构可以包括用于致动和膨胀插入到骨中的螺钉部分的第二螺钉。 该组件可用于经历循环负荷的骨骼的刚性固定，例如胸骨和下颌骨。 还描述了刚性骨固定的方法。
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4.发明授权Collagen and fibrin microthreads in a discrete thread model of in vitro ACL scaffold regeneration 有权胶原和纤维蛋白微丝在体外ACL支架再生的离散线模型中公开(公告)号：US08865869B2
公开(公告)日：2014-10-21
申请号：US12293771
申请日：2007-03-15
CPC分类号： A61L27/225 , A61K38/363 , A61L31/046 , A61L2300/252 , A61L2400/04 , A61L2430/34
摘要： Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.
摘要翻译： 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。
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5.发明申请COLLAGEN AND FIBRIN MICROTHREADS IN A DISCRETE THREAD MODEL OF IN VITRO ACL SCAFFOLD REGENERATION 有权胶原蛋白和纤维蛋白复合体在血管内皮细胞再生中的分离螺旋模型公开(公告)号：US20110034388A1
公开(公告)日：2011-02-10
申请号：US12293771
申请日：2007-03-15
CPC分类号： A61L27/225 , A61K38/363 , A61L31/046 , A61L2300/252 , A61L2400/04 , A61L2430/34
摘要： Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.
摘要翻译： 提供包含纤维蛋白微丝的组合物。 组合物可以包括一种或多种治疗剂，包括细胞因子和白介素，细胞外基质蛋白和/或其生物活性片段（例如，含RGD的肽），激素，维生素，核酸，化学治疗剂，抗生素和细胞。 还提供了制备包含纤维蛋白微丝的组合物的方法。 还提供了使用组合物修复或改善损坏或缺陷的器官或组织的方法。
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公开(公告)号：US09566098B2
公开(公告)日：2017-02-14
申请号：US13451118
申请日：2012-04-19
IPC分类号： A61B17/80
CPC分类号： A61B17/8076 , A61B17/8033 , A61B17/8038 , A61B17/8042 , A61B17/8047 , A61B17/8052
摘要： An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.
摘要翻译： 用于刚性骨固定的组件包括板和螺钉。 螺钉可以在板内以非锁定构型自由旋转，以将板固定在骨上。 接合锁定机构以防止螺钉相对于板移动。 在一个实施例中，板包括螺纹部分和非螺纹部分。 螺钉头在非螺纹部分内旋转以拧紧螺钉并将板拉向骨头。 锁定机构可以包括在板的螺纹部分内旋转的可移动螺母，以将螺钉和板锁定在锁定模式。 该组件可用于经历循环负荷的骨骼的刚性固定，例如胸骨和下颌骨。 还描述了刚性骨固定的方法。
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公开(公告)号：US08690927B2
公开(公告)日：2014-04-08
申请号：US13071155
申请日：2011-03-24
IPC分类号： A61B17/80
CPC分类号： A61B17/8076 , A61B17/8042
摘要： An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The locking mechanism can include a second screw to actuate and expansion portion of screw inserted into the bone. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.
摘要翻译： 用于刚性骨固定的组件包括板和螺钉。 螺钉可以在板内以非锁定构型自由旋转，以将板固定在骨上。 接合锁定机构以防止螺钉相对于板移动。 在一个实施例中，板包括螺纹部分和非螺纹部分。 螺钉头在非螺纹部分内旋转以拧紧螺钉并将板拉向骨头。 锁定机构可以包括在板的螺纹部分内旋转的可移动螺母，以将螺钉和板锁定在锁定模式。 锁定机构可以包括用于致动和膨胀插入到骨中的螺钉部分的第二螺钉。 该组件可以用于经历循环负荷的骨骼的刚性固定，例如胸骨和下颌骨。 还描述了刚性骨固定的方法。
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公开(公告)号：US20120323283A1
公开(公告)日：2012-12-20
申请号：US13451118
申请日：2012-04-19
IPC分类号： A61B17/80
CPC分类号： A61B17/8076 , A61B17/8033 , A61B17/8038 , A61B17/8042 , A61B17/8047 , A61B17/8052
摘要： An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non-locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non-threaded portion. The screw head rotates within the non-threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism can include a moveable nut that rotates within the threaded portion of the plate to lock the screw and plate in a locking mode. The assembly can be used for rigid fixation of bones that experience cyclic loads, such as the sternum and mandible. Methods of rigid bone fixation are also described.
摘要翻译： 用于刚性骨固定的组件包括板和螺钉。 螺钉可以在板内以非锁定构型自由旋转，以将板固定在骨上。 接合锁定机构以防止螺钉相对于板移动。 在一个实施例中，板包括螺纹部分和非螺纹部分。 螺钉头在非螺纹部分内旋转以拧紧螺钉并将板拉向骨头。 锁定机构可以包括在板的螺纹部分内旋转的可移动螺母，以将螺钉和板锁定在锁定模式。 该组件可用于经历循环负荷的骨骼的刚性固定，例如胸骨和下颌骨。 还描述了刚性骨固定的方法。
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公开(公告)号：US20060030791A1
公开(公告)日：2006-02-09
申请号：US11107302
申请日：2005-04-15
申请人： Kristen Billiar , Raymond Dunn
发明人： Kristen Billiar , Raymond Dunn
IPC分类号： A61B5/103
CPC分类号： A61B5/0053 , A61B5/442 , A61B5/4878
摘要： The preferred embodiments of the present invention are directed at a device that provides a reliable, accurate and quantifiable measure of a patient's edema. The device improves on the current method of digital manipulation by evaluating the pitting phenomena in a user-independent manner. The output of the device allows a physician to categorize edema into at least ten different levels of severity. The systems of the present invention provides the ability to distinguish between tissues of varying viscosity.
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