公开(公告)号：US20070003633A1

公开(公告)日：2007-01-04

申请号：US11105963

申请日：2005-04-14

申请人： Ginger Abraham ,  Maury Cosman ,  Kristen Billiar ,  Ryan Mercer ,  Bruce Miller

发明人： Ginger Abraham ,  Maury Cosman ,  Kristen Billiar ,  Ryan Mercer ,  Bruce Miller

IPC分类号： A61K35/38 ,  A61K35/37

CPC分类号： A61F2/062 ,  B29C53/562

摘要： An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.

摘要翻译： 用于从平面片状基体形成管构造的装置包括支撑两个相对的安装件并跨过相对的安装件的支架是平行布置地保持的心轴，多孔杆和弹簧加载的辊; 用于在相对的安装件上对准和接合心轴的引导件; 以及用于在平面片基体上施加切向力以防止起皱的装置。 多孔棒具有延伸其长度的内腔，并且具有在多孔棒的内腔之间连通到杆的表面以使水均匀通过的孔。 弹簧加载的滚筒沿着多孔棒的长度延伸，在滚筒和心轴之间形成一条接触线。 心轴与平面的基质片材接触并且旋转，使得基质的连续部分接触多孔棒并被穿过多孔棒的孔的水轻轻地润湿，并且缠绕在心轴上以形成管构造 。

公开(公告)号：US06978815B2

公开(公告)日：2005-12-27

申请号：US10325444

申请日：2002-12-19

申请人： Maury D. Cosman ,  Kristen Billiar ,  Ryan Mercer ,  Bruce Miller

发明人： Maury D. Cosman ,  Kristen Billiar ,  Ryan Mercer ,  Bruce Miller

IPC分类号： A61F2/06 ,  B29C53/56 ,  B65H81/00

CPC分类号： A61F2/062 ,  B29C53/562

摘要： An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.

摘要翻译： 用于从平面片状基体形成管构造的装置包括支撑两个相对的安装件并跨过相对的安装件的支架是平行布置地保持的心轴，多孔杆和弹簧加载的辊; 用于在相对的安装件上对准和接合心轴的引导件; 以及用于在平面片基体上施加切向力以防止起皱的装置。 多孔棒具有延伸其长度的内腔，并且具有在多孔棒的内腔之间连通到杆的表面以使水均匀通过的孔。 弹簧加载的滚筒沿着多孔棒的长度延伸，在滚筒和心轴之间形成一条接触线。 心轴与平面的基质片材接触并且旋转，使得基质的连续部分接触多孔棒并被穿过多孔棒的孔的水轻轻地润湿，并且缠绕在心轴上以形成管构造 。

公开(公告)号：US20060024380A1

公开(公告)日：2006-02-02

申请号：US11130018

申请日：2005-05-16

申请人： Ginger Abraham ,  Robert Carr ,  Paul Kemp ,  Ryan Mercer ,  Linda Baker

发明人： Ginger Abraham ,  Robert Carr ,  Paul Kemp ,  Ryan Mercer ,  Linda Baker

IPC分类号： A61K35/38 ,  C12Q1/68

CPC分类号： A61L27/3687 ,  A61K35/12 ,  A61K38/39 ,  A61L27/24 ,  A61L27/3695 ,  A61L2430/40 ,  Y10S623/917 ,  Y10S623/92

摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

公开(公告)号：US5993844A

公开(公告)日：1999-11-30

申请号：US853372

申请日：1997-05-08

申请人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Paul D. Kemp ,  Ryan Mercer ,  Linda Baker

发明人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Paul D. Kemp ,  Ryan Mercer ,  Linda Baker

IPC分类号： A61F13/00 ,  A01N1/02 ,  A61F2/00 ,  A61F2/02 ,  A61F2/06 ,  A61F2/24 ,  A61F2/28 ,  A61K35/12 ,  A61L27/24 ,  A61L27/36 ,  C12N5/08

CPC分类号： A61L27/3687 ,  A61K35/12 ,  A61K38/39 ,  A61L27/24 ,  A61L27/3695 ,  A61L2430/40 ,  Y10S623/917 ,  Y10S623/92

摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。

公开(公告)号：US06599690B1

公开(公告)日：2003-07-29

申请号：US09450577

申请日：1999-11-30

申请人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Paul D. Kemp ,  Ryan Mercer ,  Linda Baker

发明人： Ginger A. Abraham ,  Robert M. Carr, Jr. ,  Paul D. Kemp ,  Ryan Mercer ,  Linda Baker

IPC分类号： A01N102

CPC分类号： A61L27/3687 ,  A61K35/12 ,  A61K38/39 ,  A61L27/24 ,  A61L27/3695 ,  A61L2430/40 ,  Y10S623/917 ,  Y10S623/92

摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.

摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。