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    MZB1, A NOVEL B CELL FACTOR, AND USES THEREOF
    1.
    发明申请
    MZB1, A NOVEL B CELL FACTOR, AND USES THEREOF 审中-公开
    MZB1，新型B细胞因子及其用途

    公开(公告)号：US20130189266A1

    公开(公告)日：2013-07-25

    申请号：US13740772

    申请日：2013-01-14

    申请人： Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.

    发明人： Rudolf Grosschedl ,  Henrik Flach ,  Sola Kim ,  Marlena Duchniewicz ,  Bernadette Schreiner

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/475

    摘要： The marginal zone (MZ) and B1 subsets of B cells, which differ from conventional follicular (FO) B cells both developmentally and functionally, are involved in early responses to infectious pathogens and the production of self-reactive antibodies. A novel gene, mzb1, is expressed at high levels in MZ and B1 B cells but at low level, if at all, in FO B cells. MZB1 is involved in the regulation of proliferation, BCR-mediated signal transduction, and antibody production in B cells. Inhibitors, activators and enhancers of MZB1 expression or activity can be used as immune modulators for research and therapeutic purposes.

    摘要翻译： 与发育和功能上的常规卵泡（FO）B细胞不同的B细胞的边缘区（MZ）和B1亚群参与对感染性病原体的早期应答和自身反应性抗体的产生。 一种新型基因mzb1在MZ和B1B细胞中以高水平表达，但在FO B细胞中表达较低水平（如果有的话）。 MZB1参与B细胞增殖，BCR介导的信号转导和抗体产生的调控。 MZB1表达或活性的抑制剂，活化剂和增强剂可用作研究和治疗目的的免疫调节剂。