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公开(公告)号:US20100056386A1
公开(公告)日:2010-03-04
申请号:US12404059
申请日:2009-03-13
CPC分类号: C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
摘要翻译: 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 图书馆旨在反映人类免疫系统自然产生的免疫缺陷病毒库,具有或不具有衍生自其他物种的DH区段,并且基于通过检查可公开获得的抗体序列数据库而得出的合理设计。
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2.
公开(公告)号:US08877688B2
公开(公告)日:2014-11-04
申请号:US12404059
申请日:2009-03-13
IPC分类号: C40B40/08
CPC分类号: C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
摘要翻译: 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 图书馆旨在反映人类免疫系统自然产生的免疫缺陷病毒库,具有或不具有衍生自其他物种的DH区段,并且基于通过检查可公开获得的抗体序列数据库而得出的合理设计。
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3.
公开(公告)号:US08691730B2
公开(公告)日:2014-04-08
申请号:US12210072
申请日:2008-09-12
IPC分类号: C40B40/08
CPC分类号: C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译: 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库,并且基于通过检查公开可得到的人抗体序列数据库的合理设计。
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公开(公告)号:US20090181855A1
公开(公告)日:2009-07-16
申请号:US12210072
申请日:2008-09-12
CPC分类号: C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译: 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。 这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库,并且基于通过检查公开可得到的人抗体序列数据库的合理设计。
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公开(公告)号:US09354228B2
公开(公告)日:2016-05-31
申请号:US13810570
申请日:2011-07-14
IPC分类号: C40B40/08 , G01N33/543 , C07K16/00 , C12N15/10 , C40B50/02
CPC分类号: C12N15/1089 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08 , C40B50/02 , C40B50/06 , G01N33/543
摘要: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
摘要翻译: 本发明克服了通过专门设计具有定向序列和长度多样性的文库来生成抗体编码多核苷酸文库的已知方法中的不足之处。
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公开(公告)号:US20130197201A1
公开(公告)日:2013-08-01
申请号:US13810570
申请日:2011-07-14
IPC分类号: G01N33/543
CPC分类号: C12N15/1089 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08 , C40B50/02 , C40B50/06 , G01N33/543
摘要: The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
摘要翻译: 本发明通过专门设计具有定向序列和长度多样性的文库来克服已知的用于产生抗体编码多核苷酸文库的方法的不足之处。
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公开(公告)号:US07846440B2
公开(公告)日:2010-12-07
申请号:US12281925
申请日:2008-02-15
IPC分类号: A61K39/395 , A61P35/00 , C07K16/18
CPC分类号: C07K16/32 , A61K9/0019 , A61K31/337 , A61K31/517 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要: The present invention provides a novel class of monoclonal antibodies which bind ErbB3 receptor and inhibits various ErbB3 functions. In a particular embodiment, the antibodies are capable of binding to ErbB3 and inhibiting ligand mediated phosphorylation of the receptor.
摘要翻译: 本发明提供了一种新型的结合ErbB3受体并抑制各种ErbB3功能的单克隆抗体。 在一个具体实施方案中,抗体能够结合ErbB3并抑制受体的配体介导的磷酸化。
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公开(公告)号:US08927694B2
公开(公告)日:2015-01-06
申请号:US13130007
申请日:2009-10-14
IPC分类号: C07K16/00 , C07K14/765 , A61K38/00
CPC分类号: C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/765 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/94 , C07K2319/31 , C07K2319/74
摘要: Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is covalently bonded to amino and carboxy terminal binding moieties that are first and second single-chain Fv molecules (scFvs). Exemplified conjugates are useful, e.g., in reducing tumor cell proliferation, e.g., for therapeutic therapeutic applications. Also disclosed are methods and kits for the diagnostic and therapeutic application of an HSA linker conjugate.
摘要翻译: 披露了与其结合的结合,诊断和治疗剂的人血清白蛋白(HSA)接头和HSA接头。 还公开了缀合物,其中HSA接头共价键合到作为第一和第二单链Fv分子(scFv)的氨基和羧基末端结合部分。 示例性缀合物可用于例如减少肿瘤细胞增殖,例如用于治疗性治疗应用。 还公开了用于诊断和治疗应用HSA接头缀合物的方法和试剂盒。
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公开(公告)号:US20120003221A1
公开(公告)日:2012-01-05
申请号:US13130007
申请日:2009-10-14
IPC分类号: A61K39/395 , A61P35/00 , C07K19/00
CPC分类号: C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/765 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/94 , C07K2319/31 , C07K2319/74
摘要: Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is covalently bonded to amino and carboxy terminal binding moieties that are first and second single-chain Fv molecules (scFvs). Exemplified conjugates are useful, e.g., in reducing tumor cell proliferation, e.g., for therapeutic therapeutic applications. Also disclosed are methods and kits for the diagnostic and therapeutic application of an HSA linker conjugate.
摘要翻译: 披露了与其结合的结合,诊断和治疗剂的人血清白蛋白(HSA)接头和HSA接头。 还公开了缀合物,其中HSA接头共价键合到作为第一和第二单链Fv分子(scFv)的氨基和羧基末端结合部分。 示例性缀合物可用于例如减少肿瘤细胞增殖,例如用于治疗性治疗应用。 还公开了用于诊断和治疗应用HSA接头缀合物的方法和试剂盒。
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公开(公告)号:US20110059076A1
公开(公告)日:2011-03-10
申请号:US12757801
申请日:2010-04-09
IPC分类号: A61K39/395 , C07K14/765 , A61K31/517 , A61K31/337 , A61K31/4196 , A61K38/00 , A61K31/4375 , A61K33/24 , A61K31/282 , A61K31/138 , A61K31/519 , A61K31/513 , A61K31/704 , A61P35/00
CPC分类号: C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/765 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/94 , C07K2319/31 , C07K2319/74
摘要: Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is covalently bonded to amino and carboxy terminal binding moieties that are first and second single-chain Fv molecules (scFvs). Exemplified conjugates are useful, e.g., in reducing tumor cell proliferation, e.g., for therapeutic therapeutic applications. Also disclosed are methods and kits for the diagnostic and therapeutic application of an HSA linker conjugate.
摘要翻译: 披露了与其结合的结合,诊断和治疗剂的人血清白蛋白(HSA)接头和HSA接头。 还公开了缀合物,其中HSA接头共价键合到作为第一和第二单链Fv分子(scFv)的氨基和羧基末端结合部分。 示例性缀合物可用于例如减少肿瘤细胞增殖,例如用于治疗性治疗应用。 还公开了用于诊断和治疗应用HSA接头缀合物的方法和试剂盒。
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