公开(公告)号：US20180179281A1

公开(公告)日：2018-06-28

申请号：US15890048

申请日：2018-02-06

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen ,  Scott E. Strome ,  Eugene D. Kwon

IPC: C07K16/28 ,  G01N33/574 ,  A61K38/20 ,  G01N33/569 ,  G01N33/50 ,  A61K38/21 ,  C12Q1/6886 ,  C12N15/113 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/2066 ,  A61K38/208 ,  A61K38/2086 ,  A61K38/212 ,  A61K38/215 ,  A61K38/217 ,  A61K2039/505 ,  C07K16/2827 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/76 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5088 ,  G01N33/5091 ,  G01N33/56972 ,  G01N33/57407 ,  G01N33/57438 ,  G01N33/57484

Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

公开(公告)号：US20160096890A1

公开(公告)日：2016-04-07

申请号：US14845020

申请日：2015-09-03

Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： Lieping Chen

IPC: C07K16/28

CPC classification number: C07K14/70532 ,  A61K38/00 ,  A61K39/39 ,  A61K2035/124 ,  C07K14/47 ,  C07K16/00 ,  C07K16/2827 ,  C07K2317/24 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/76 ,  C07K2319/74 ,  G01N33/502 ,  G01N33/505 ,  G01N2333/70532

Abstract: The invention provides novel polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

公开(公告)号：US11760787B2

公开(公告)日：2023-09-19

申请号：US16707719

申请日：2019-12-09

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen

IPC: C07K14/705 ,  C07K19/00 ,  A61K38/00 ,  A61P37/00 ,  C07K16/28 ,  C07K16/46 ,  C07K16/18

CPC classification number: C07K14/70532 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  A61K38/00 ,  C07K2317/52 ,  C07K2319/70

Abstract: B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.

公开(公告)号：US20210380690A1

公开(公告)日：2021-12-09

申请号：US17402262

申请日：2021-08-13

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen ,  Scott E. Strome ,  Eugene D. Kwon

IPC: C07K16/28 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/569 ,  G01N33/574 ,  A61K38/20 ,  A61K38/21 ,  C07K16/30

Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

公开(公告)号：US09803015B2

公开(公告)日：2017-10-31

申请号：US15047445

申请日：2016-02-18

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen ,  Scott E. Strome ,  Eugene D. Kwon

IPC: C07K16/28 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/569 ,  G01N33/574 ,  A61K38/20 ,  A61K38/21 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/2066 ,  A61K38/208 ,  A61K38/2086 ,  A61K38/212 ,  A61K38/215 ,  A61K38/217 ,  A61K2039/505 ,  C07K16/2827 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/76 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/5088 ,  G01N33/5091 ,  G01N33/56972 ,  G01N33/57407 ,  G01N33/57438 ,  G01N33/57484

Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

公开(公告)号：US20170204185A1

公开(公告)日：2017-07-20

申请号：US15419172

申请日：2017-01-30

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen

IPC: C07K16/28

CPC classification number: C07K16/2827 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K14/70532 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/75 ,  C07K2319/00 ,  C12N15/85

Abstract: The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

公开(公告)号：US20150203564A1

公开(公告)日：2015-07-23

申请号：US14645070

申请日：2015-03-11

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen

IPC: C07K14/705 ,  C07K16/18

CPC classification number: C07K14/70532 ,  A61K38/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/46 ,  C07K2317/52 ,  C07K2319/70

Abstract: B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.

Abstract translation: 本文提供了B7-H5共刺激多肽，编码此类多肽的核酸，以及使用多肽和核酸来增强T细胞应答的方法。

公开(公告)号：US20140234352A1

公开(公告)日：2014-08-21

申请号：US14191876

申请日：2014-02-27

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen

IPC: C07K14/705 ,  C12N15/85 ,  A61K47/48

CPC classification number: C07K16/2827 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K14/70532 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/75 ,  C07K2319/00 ,  C12N15/85

Abstract: The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

Abstract translation: 本发明提供了可用于共刺激T细胞，编码它们的分离的核酸分子，含有核酸分子的载体和含有载体的细胞的新型B7-H3和B7-H4多肽。 还包括制备和使用这些共刺激多肽的方法。

公开(公告)号：US11242387B2

公开(公告)日：2022-02-08

申请号：US16544357

申请日：2019-08-19

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen ,  Scott E. Strome ,  Eugene D. Kwon

IPC: C12N15/113 ,  C07K16/28 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/569 ,  G01N33/574 ,  A61K38/20 ,  A61K38/21 ,  C07K16/30 ,  A61K39/00

Abstract: The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

公开(公告)号：US20200239542A1

公开(公告)日：2020-07-30

申请号：US16707719

申请日：2019-12-09

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Lieping Chen

IPC: C07K14/705 ,  C07K16/18 ,  C07K16/46 ,  C07K16/28

Abstract: B7-H5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a T cell response are provided herein.