公开(公告)号：US20240109870A1

公开(公告)日：2024-04-04

申请号：US18383687

申请日：2023-10-25

申请人： McMaster University

发明人： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Serniuck

IPC分类号： C07D403/12 ,  C07D233/90 ,  C07D493/10

CPC分类号： C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

摘要： The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.


ABD-(L1)n-ALD-(L2)m-R  I