公开(公告)号：US20190276522A1

公开(公告)日：2019-09-12

申请号：US16170468

申请日：2018-10-25

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: C07K16/18 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68 ,  G01N33/537

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.

公开(公告)号：US10889639B2

公开(公告)日：2021-01-12

申请号：US16170468

申请日：2018-10-25

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: A61K45/00 ,  G01N33/567 ,  C07K16/18 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68 ,  A61K39/00

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.

公开(公告)号：US10160800B2

公开(公告)日：2018-12-25

申请号：US15611416

申请日：2017-06-01

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: A61K45/00 ,  G01N33/567 ,  A61P25/16 ,  A61P25/28 ,  C07K16/18 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68 ,  A61K39/00

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.

公开(公告)号：US11560424B2

公开(公告)日：2023-01-24

申请号：US17111159

申请日：2020-12-03

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: A61K45/00 ,  G01N33/567 ,  C07K16/18 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68 ,  A61K39/00

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.

公开(公告)号：US20210179698A1

公开(公告)日：2021-06-17

申请号：US17111159

申请日：2020-12-03

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: C07K16/18 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.

公开(公告)号：US20230331830A1

公开(公告)日：2023-10-19

申请号：US18099671

申请日：2023-01-20

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: C07K16/18 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/68

CPC classification number: C07K16/18 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/6896 ,  A61K2039/505

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.

公开(公告)号：US20180002411A1

公开(公告)日：2018-01-04

申请号：US15611416

申请日：2017-06-01

Applicant: MedImmune Limited

Inventor： Darren Schofield ,  Michael Perkinton ,  Lorraine Irving ,  George Thom

IPC: C07K16/18 ,  G01N33/577 ,  G01N33/543 ,  G01N33/68 ,  G01N33/537

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/524 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/92 ,  G01N33/537 ,  G01N33/543 ,  G01N33/577 ,  G01N33/6896

Abstract: The invention provides antibodies that specifically bind human α-synuclein with a high affinity and reduces α-synuclein spreading in vivo, recombinant polypeptides comprising said antibodies or antigen-binding fragment thereof and methods for generating such polypeptides, as well as compositions and methods for generating α-synuclein antibodies, and methods of using α-synuclein antibodies for the treatment of diseases of the central nervous system, in particular alpha-synucleinopathies.