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公开(公告)号：US20220306754A1
公开(公告)日：2022-09-29
申请号：US17697041
申请日：2022-03-17
申请人： MedImmune Limited
发明人： Josquin NYS , Albert THOM , Peter CARIUK , Darren SCHOFIELD , Aidan RILEY , Catherine HUNTINGTON , David REES , Lorraine IRVING , Matthew ROBINSON
摘要： The invention relates to binding molecules, such as antibodies, that bind to the chemokine receptor CCR9. More particularly, the invention relates to the treatment of CCR9-mediated diseases or conditions such as inflammatory bowel disease (IBD), and methods for the detection of CCR9, which make use of the binding molecules of the invention.
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公开(公告)号：US20210347900A1
公开(公告)日：2021-11-11
申请号：US17377863
申请日：2021-07-16
申请人： MedImmune Limited
发明人： Andrew BUCHANAN , Matthieu CHODORGE , Peter CARIUK , Johanna HUSMARK , Clare BALENDRAN , Deepesh PANDEY , Fumin CHANG , Daniel E. BERKOWITZ , Lewis H. ROMER
摘要： This disclosure provides LOX1 (LOX1) binding proteins such as anti-LOX1 antibodies, and compositions and methods for making these binding proteins. In certain aspects the LOX1-binding proteins provided herein, inhibit, or antagonize LOX1 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating conditions associated with atherosclerosis, thrombosis, coronary artery disease (CAD), ischemia (e.g., myocardial ischemia), infarction (e.g., myocardial infarction), acute coronary syndrome (ACS), stroke, reperfusion injury, restenosis, peripheral vascular disease, hypertension, heart failure, inflammation (e.g., chronic inflammation), angiogenesis, preeclampsia, cancer and other LOX1-mediated diseases and conditions.
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公开(公告)号：US20190262368A1
公开(公告)日：2019-08-29
申请号：US16179135
申请日：2018-11-02
申请人： MedImmune Limited
发明人： Andrew BUCHANAN , Matthieu CHODORGE , Peter CARIUK , Johanna HUSMARK , Clare BALENDRAN , Deepesh PANDEY , Fumin CHANG , Daniel E. BERKOWITZ , Lewis H. ROMER
IPC分类号： A61K31/7068 , A61P9/10 , C07K16/28 , C12N15/113 , C12N5/095 , C07K16/30 , G01N33/574 , A61K39/395 , A61P9/04 , A61P9/12
摘要： This disclosure provides LOX1 (LOX1) binding proteins such as anti-LOX1 antibodies, and compositions and methods for making these binding proteins. In certain aspects the LOX1-binding proteins provided herein, inhibit, or antagonize LOX1 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating conditions associated with atherosclerosis, thrombosis, coronary artery disease (CAD), ischemia (e.g., myocardial ischemia), infarction (e.g., myocardial infarction), acute coronary syndrome (ACS), stroke, reperfusion injury, restenosis, peripheral vascular disease, hypertension, heart failure, inflammation (e.g., chronic inflammation), angiogenesis, preeclampsia, cancer and other LOX1-mediated diseases and conditions.
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公开(公告)号：US20170304343A1
公开(公告)日：2017-10-26
申请号：US15516115
申请日：2015-09-30
申请人： MedImmune Limited
发明人： Andrew BUCHANAN , Matthieu CHODORGE , Peter CARIUK , Johanna HUSMARK , Clare BALENDRAN , Deepesh PANDEY , Fumin CHANG , Daniel E. BERKOWITZ , Lewis H. ROMER
IPC分类号： A61K31/7068 , C07K16/30 , C12N5/095 , C07K16/28 , G01N33/574 , G01N33/00 , A61K39/00 , C12N5/00
CPC分类号： A61K31/7068 , A61K39/395 , A61K2039/505 , A61P9/04 , A61P9/10 , A61P9/12 , C07K14/47 , C07K16/28 , C07K16/2851 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00 , C12N5/00 , C12N5/0695 , C12N15/1138 , C12N2310/14 , G01N33/00 , G01N33/574
摘要： This disclosure provides LOX1 (LOX1) binding proteins such as anti-LOX1 antibodies, and compositions and methods for making these binding proteins. In certain aspects the LOX1-binding proteins provided herein, inhibit, or antagonize LOX1 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating conditions associated with atherosclerosis, thrombosis, coronary artery disease (CAD), ischemia (e.g., myocardial ischemia), infarction (e.g., myocardial infarction), acute coronary syndrome (ACS), stroke, reperfusion injury, restenosis, peripheral vascular disease, hypertension, heart failure, inflammation (e.g., chronic inflammation), angiogenesis, preeclampsia, cancer and other LOX1-mediated diseases and conditions.
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