公开(公告)号：US20150375006A1

公开(公告)日：2015-12-31

申请号：US14732408

申请日：2015-06-05

Applicant: Medtronic, Inc.

Inventor： Timothy J. Denison ,  Kunal Paralikar ,  Gordon Orvis Munns ,  Wesley A. Santa ,  Peng Cong ,  Christian S. Nielsen ,  John D. Norton ,  John G. Keimel

IPC: A61N5/06

CPC classification number: A61N5/0601 ,  A61B2017/00084 ,  A61B2018/00839 ,  A61M5/14276 ,  A61N1/086 ,  A61N1/365 ,  A61N5/062 ,  A61N5/0622 ,  A61N2005/0612 ,  A61N2005/0626 ,  A61N2005/063 ,  A61N2005/0651

Abstract: A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.

Abstract translation: 用于递送光学刺激的方法包括用对波长范围内的光敏感的光敏通道蛋白转染靶组织，通过光学刺激装置将波长范围内的光传送到目标组织，基本上同时将光传递到靶 组织，感测生物电信号，基于生物电信号确定患者治疗状态，以及基于感测到的患者治疗状态来调整到目标组织的光的传送。