公开(公告)号：US20040062852A1

公开(公告)日：2004-04-01

申请号：US10260659

申请日：2002-09-30

Applicant: Medtronic, Inc.

Inventor： Peter T. Schroeder ,  Kimberly A. Chaffin

IPC: A61L002/00 ,  B05D003/02 ,  B05C013/00

CPC classification number: A61N1/0568 ,  A61N1/0575 ,  A61N1/375

Abstract: A method for coating a medical device with a drug is provided. Energy, preferably thermal energy, is applied to a crystalline deposit of a drug on the surface of a medical device to increase the molecular mobility and form a conformable drug coating with a low density of micro-cracks and other mechanical defects that can degrade the coating toughness and effective adhesion to the device surface. In a preferred embodiment, solution evaporation methods are used to deposit a crystalline coating of an anti-inflammatory steroid on a medical electrode. Heat applied at a controlled temperature, for a predetermined amount of time, induces a solid-state phase change of the drug coating providing a smooth, uniform, well-attached, conformable coating to form a layer that will elute from the electrode over time when implanted in a patient's body.

Abstract translation: 提供了一种用药物涂覆医疗器械的方法。 将能量，优选热能施加到医疗装置表面上的药物的结晶沉积物以增加分子迁移率并形成具有低密度的微裂纹和其它可能降解涂层的机械缺陷的适形药物涂层 韧性和对装置表面的有效粘附。 在优选的实施方案中，使用溶液蒸发方法将抗炎类固醇的结晶涂层沉积在医用电极上。 在受控温度下施加的热量达预定时间量，引起药物涂层的固态相变，提供平滑，均匀，良好附着的贴合涂层，以形成随时间从电极洗脱的层 植入患者的身体。