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公开(公告)号：US20230092658A1
公开(公告)日：2023-03-23
申请号：US17410268
申请日：2021-08-24
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Eric J. Panken , Michelle A. Case , Rene A. Molina , Abbey Beuning Holt Becker , Christopher L. Pulliam
Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive information representing a plurality of signals sensed from a tissue of a patient via a plurality of electrode combinations, wherein the plurality of electrode combinations comprises different electrode combinations comprising electrodes disposed at different positions of the lead implanted in the patient, determine one or more features from the information representing the plurality of signals, and compare the one or more features to a plurality of templates, each template of the plurality of templates representing respective locations of a signal source within the tissue. The system may then determine, based on the comparison of the one or more features to the plurality of templates, an estimated location of the signal source with respect to the lead.
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公开(公告)号：US20220062640A1
公开(公告)日：2022-03-03
申请号：US17462676
申请日：2021-08-31
Applicant: Medtronic, Inc.
Inventor： Robert S. Raike , Jadin C. Jackson , Scott R. Stanslaski , Eric J. Panken , Christopher L. Pulliam , Timothy R. Abraham , Michelle A. Case , Paula Andrea Elma Dassbach Green , Abbey Beuning Holt Becker , Rene A. Molina
Abstract: Devices, systems, and techniques for identifying electrodes closest to a target region of tissue are described. In one example, a device includes sensing circuitry configured to sense electrical signals from a plurality of electrode combinations. Processing circuitry identifies a first electrode combination of a first subset of electrode combinations. Each electrode combination of the first subset of electrode combination includes electrodes located at different axial positions along a length of the medical lead. The processing circuitry identifies a second electrode combination of a second subset of electrode combinations. Each electrode combination of the second subset of electrode combinations includes electrodes located at a same axial position and different circumferential positions around a perimeter of the medical lead. The processing circuitry then determines a third electrode combination and controls delivery of electrical stimulation via the third electrode combination.
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公开(公告)号：US12070605B2
公开(公告)日：2024-08-27
申请号：US17651374
申请日：2022-02-16
Applicant: Medtronic, Inc.
Inventor： Benjamin P. Isaacson , David E. Linde , Scott R. Stanslaski , Christopher L. Pulliam , Rene A. Molina , Abbey Beuning Holt Becker , David L. Carlson , Nicholas D. Buse , Duane L. Bourget , Thaddeus S. Brink
CPC classification number: A61N1/36175 , A61N1/0534 , A61N1/36135 , A61N1/36192 , A61N1/37235
Abstract: An example method includes determining, by an implantable medical device (IMD), an electrode of a plurality of electrodes of a lead to be used to deliver electrical stimulation to a patient at a particular time; selecting, by the IMD and based on the determined electrode, a set of electrodes of the plurality of electrodes; and sensing, by the IMD and via the selected set of electrodes, electrical signals of the patient at the particular time.
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4.发明公开公开(公告)号：US20230347152A1
公开(公告)日：2023-11-02
申请号：US18307585
申请日：2023-04-26
Applicant: Medtronic, Inc.
Inventor： Kristin N. Hageman , Scott R. Stanslaski , Erik J. Peterson , Rene A. Molina , Paul H. Stypulkowski , David A. Dinsmoor , Leonid M. Litvak
CPC classification number: A61N1/36139 , A61N1/025
Abstract: A system for closed-loop therapy includes memory configured to store a first set of one or more parameters for a first set of therapeutic electrical stimulation signals. The system includes processing circuitry configured to determine one or more local field potential (LFP) measurements of an LFP that is intrinsically generated, cause stimulation generation circuitry to deliver one or more electrical stimulation signals, determine one or more evoked resonant neural activity (ERNA) signals that are evoked by delivery of respective ones of the electrical stimulation signals, determine a second set of one or more parameters for a second set of therapeutic electrical stimulation signals based on the one or more evoked signals and the one or more LFP measurements, and cause the stimulation generation circuitry to deliver the second set of the one or more therapeutic electrical stimulation signals.
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公开(公告)号：US20230069981A1
公开(公告)日：2023-03-09
申请号：US17818246
申请日：2022-08-08
Applicant: Medtronic, Inc.
Inventor： Benjamin P. Isaacson , Scott R. Stanslaski , Abbey Beuning Holt Becker , Rene A. Molina , Caleb C. Zarns , David E. Linde , Nicholas D. Buse , Thaddeus S. Brink
IPC: A61N1/36
Abstract: An example system includes stimulation generation circuitry configured to deliver electrical stimulation to a patient; sensing circuitry configured to sense one or more biomarker signals; and processing circuitry configured to: cause delivery of electrical stimulation with the patient in a first patient state; receive a first instance of a biomarker signal in presence of the electrical stimulation with the patient in the first patient state; cause delivery of electrical stimulation with the patient in a second patient state; receive a second instance of the biomarker signal in presence of the electrical stimulation with the patient in the second patient state; determine whether a difference between the first instance of the biomarker signal and the second instance of the biomarker signal satisfies a threshold; select a therapy mode based on whether the difference satisfies the threshold; and cause delivery of electrical stimulation in accordance with the selected therapy mode.
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Patent Agency Ranking
公开(公告)号：US20220409881A1
公开(公告)日：2022-12-29
申请号：US17846274
申请日：2022-06-22
Applicant: MEDTRONIC, INC.
Inventor： Rene A. Molina , Michelle A. Case , Paula A. Dassbach , Abbey B.H. Becker , Christopher L. Pulliam
Abstract: Implantable medical leads include rows of electrode segments where electrode segments within a given row may be a different size and/or adjacent electrode segments of adjacent rows may be of a different size. The arrangement of the electrode segments of different sizes may avoid intersections of the spaces between segments to reduce the size and/or number of blind spots that otherwise occur for delivery of stimulation signals and/or sensing of physiological signals. The electrode segments of different sizes may be of a same shape type but with different proportions.
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公开(公告)号：US20230263444A1
公开(公告)日：2023-08-24
申请号：US18101885
申请日：2023-01-26
Applicant: Medtronic, Inc.
Inventor： Michelle A. Case , Eric J. Panken , Rene A. Molina , Paula A.E. Dassbach Green , Abbey Beuning Holt Becker
CPC classification number: A61B5/24 , A61B5/7267 , G06N3/08
Abstract: Systems and methods for programming an implantable medical device comprising a simulated environment with at least one lead having a plurality of electrodes, computing hardware of at least one processor and a memory operably coupled to the at least one processor, and instructions that, when executed on the computing hardware, cause the computing hardware to implement a training sub-system configured to conduct a brain sense survey using the simulated environment, develop at least one machine learning model based on the brain sense survey, apply the at least one machine learning model to in-vivo patient data to determine at least one predicted electrode from the plurality of electrodes relative to an oscillatory source, visualize the at least one predicted electrode, and program a medical device based on the at least one predicted electrode.
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公开(公告)号：US20220266033A1
公开(公告)日：2022-08-25
申请号：US17651500
申请日：2022-02-17
Applicant: Medtronic, Inc.
Inventor： Jadin C. Jackson , Rene A. Molina , Christopher L. Pulliam
Abstract: Devices, systems, and techniques are disclosed for managing electrical stimulation therapy and/or sensing of physiological signals such as brain signals. For example, a system is configured to receive, for each electrode combination of a plurality of electrode combinations, information representing a signal sensed in response to first electrical stimulation delivered to a patient via a lead, wherein the plurality of electrode combinations comprise different electrode combinations comprising electrode disposed at different positions around a perimeter of the lead implanted in the patient. The system may also be configured to determine, based on the information for each electrode combination of the plurality of electrode combinations, values for a threshold at different locations around the perimeter of the lead and determine, based on the values for the threshold, one or more stimulation parameter values that at least partially define second electrical stimulation deliverable to the patient via the lead.
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公开(公告)号：US11376434B2
公开(公告)日：2022-07-05
申请号：US16945639
申请日：2020-07-31
Applicant: Medtronic, Inc.
Inventor： Rene A. Molina , Scott R. Stanslaski , Jadin C. Jackson , Christopher L. Pulliam , Eric J. Panken , Michelle A. Case , Abbey Beuning Holt Becker
Abstract: Devices, systems, and techniques are configured for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.
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公开(公告)号：US11260231B2
公开(公告)日：2022-03-01
申请号：US16752224
申请日：2020-01-24
Applicant: Medtronic, Inc.
Inventor： Rene A. Molina , Robert S. Raike , Scott R. Stanslaski
Abstract: Techniques, systems, and devices are disclosed for delivering stimulation therapy to a patient. In one example, a medical device determines a first set of stimulation parameters that define entrainment stimulation pulses configured to entrain electrical activity in a patient. The medical device may control a stimulation generator to generate the entrainment stimulation pulses according to the first set of stimulation parameters. The medical device may further determine a second set of stimulation parameters that define at least one desynchronization stimulation pulse configured to disrupt at least a portion of the electrical activity entrained by the entrainment stimulation pulses. The medical device may subsequently control the stimulation generator to generate the desynchronization stimulation pulse(s) according to the second set of stimulation parameters.
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